| URN | urn:agi-llid:408 |
|---|---|
| Connectivity | 343 |
| Name | Arrb1 |
| Description | arrestin, beta 1 |
| Notes | Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described, however, their exact functions are not known. [provided by RefSeq] |
| Pathway | AdrenergicRb -> CREB signaling |
|---|---|
| AdrenergicRb -> STAT3 signaling | |
| epinephrine signaling pathway via adrenergic receptor beta | |
| angiotensin II signaling pathway via AT1 receptor | |
| corticotropin-releasing hormone signaling pathway | |
| calcium signaling pathway via the calcium-sensing receptor | |
| parathyroid hormone signaling pathway |
| GO Molecular Function | enzyme inhibitor activity |
|---|---|
| transcription factor binding | |
| phosphoprotein binding | |
| clathrin binding | |
| ubiquitin protein ligase binding | |
| insulin-like growth factor receptor binding | |
| G-protein-coupled receptor binding | |
| angiotensin receptor binding | |
| promoter binding | |
| histone acetyltransferase activity | |
| GTPase activator activity |
| GO Cellular Component | postsynaptic membrane |
|---|---|
| cell projection | |
| membrane | |
| intracellular | |
| soluble fraction | |
| plasma membrane | |
| pseudopodium | |
| cytoplasm | |
| coated pit | |
| cytoplasmic vesicle | |
| cytosol | |
| cytoplasmic membrane-bounded vesicle | |
| chromatin | |
| nucleus | |
| membrane fraction | |
| heterotrimeric G-protein complex |
| GO Biological Process | cellular membrane organization |
|---|---|
| transport | |
| negative regulation of interleukin-6 production | |
| negative regulation of interleukin-8 production | |
| sensory perception | |
| sensory perception of pain | |
| sensory perception of touch | |
| phototransduction | |
| endocytosis | |
| signal transduction | |
| negative regulation of signal transduction | |
| positive regulation of ERK1 and ERK2 cascade | |
| positive regulation of Rho protein signal transduction | |
| activation of MAPK activity | |
| desensitization of G-protein coupled receptor protein signaling pathway by arrestin | |
| G-protein signaling, coupled to cAMP nucleotide second messenger | |
| regulation of transcription | |
| regulation of cAMP catabolic process | |
| negative regulation of protein ubiquitination | |
| positive regulation of transcription from RNA polymerase II promoter | |
| positive regulation of gene-specific transcription from RNA polymerase II promoter | |
| positive regulation of histone acetylation | |
| negative regulation of NF-kappaB transcription factor activity | |
| regulation of cAMP biosynthetic process | |
| G-protein coupled receptor internalization | |
| transcription | |
| transcription from RNA polymerase II promoter | |
| protein ubiquitination | |
| histone H4 acetylation | |
| proteasomal ubiquitin-dependent protein catabolic process | |
| post-Golgi vesicle-mediated transport | |
| stress fiber assembly | |
| regulation of G-protein coupled receptor protein signaling pathway | |
| protein transport | |
| G-protein coupled receptor protein signaling pathway |
| Group | cellular membrane organization |
|---|---|
| transport | |
| negative regulation of interleukin-6 production | |
| negative regulation of interleukin-8 production | |
| sensory perception | |
| sensory perception of pain | |
| sensory perception of touch | |
| phototransduction | |
| endocytosis | |
| signal transduction | |
| negative regulation of signal transduction | |
| positive regulation of ERK1 and ERK2 cascade | |
| positive regulation of Rho protein signal transduction | |
| activation of MAPK activity | |
| desensitization of G-protein coupled receptor protein signaling pathway by arrestin | |
| G-protein signaling, coupled to cAMP nucleotide second messenger | |
| regulation of transcription | |
| regulation of cAMP catabolic process | |
| negative regulation of protein ubiquitination | |
| positive regulation of transcription from RNA polymerase II promoter | |
| positive regulation of gene-specific transcription from RNA polymerase II promoter | |
| positive regulation of histone acetylation | |
| negative regulation of NF-kappaB transcription factor activity | |
| regulation of cAMP biosynthetic process | |
| G-protein coupled receptor internalization | |
| transcription | |
| transcription from RNA polymerase II promoter | |
| protein ubiquitination | |
| histone H4 acetylation | |
| proteasomal ubiquitin-dependent protein catabolic process | |
| post-Golgi vesicle-mediated transport | |
| stress fiber assembly | |
| regulation of G-protein coupled receptor protein signaling pathway | |
| protein transport | |
| G-protein coupled receptor protein signaling pathway | |
| enzyme inhibitor activity | |
| transcription factor binding | |
| phosphoprotein binding | |
| clathrin binding | |
| ubiquitin protein ligase binding | |
| insulin-like growth factor receptor binding | |
| G-protein-coupled receptor binding | |
| angiotensin receptor binding | |
| promoter binding | |
| histone acetyltransferase activity | |
| GTPase activator activity | |
| postsynaptic membrane | |
| cell projection | |
| membrane | |
| intracellular | |
| soluble fraction | |
| plasma membrane | |
| pseudopodium | |
| cytoplasm | |
| coated pit | |
| cytoplasmic vesicle | |
| cytosol | |
| cytoplasmic membrane-bounded vesicle | |
| chromatin | |
| nucleus | |
| membrane fraction | |
| heterotrimeric G-protein complex |
| MedScan ID | 408 |
|---|
| Hugo ID | 711 |
|---|
| Human chromosome position | 11q13 |
|---|
| LocusLink ID | 408 |
|---|---|
| 109689 | |
| 25387 |
| Alias | ARB1 |
|---|---|
| ARR1 | |
| beta-arrestin-1 | |
| arrestin 2 | |
| beta-arrestin | |
| arrestin beta-1 | |
| AW208571 | |
| MGC124269 | |
| MGC124270 | |
| 1200006I17Rik | |
| G430100A01Rik | |
| beta-arrestin1 | |
| arrestin, beta 1, isoform B | |
| BARRES | |
| 1200006I17 | |
| ARB I | |
| ARR I | |
| ARRB I | |
| ARRB1 | |
| arrestin beta 1 | |
| arrestin beta 1 isoform A | |
| arrestin beta 1 isoform B | |
| arrestin beta I | |
| arrestin, beta | |
| beta-arrestin 1 | |
| beta-arrestin I | |
| G430100A01 | |
| arrestin, beta 1 | |
| RIKEN cDNA G430100A01 gene | |
| RIKEN cDNA 1200006I17 gene | |
| arrestin 1 | |
| arrestin I |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 107940 |
|---|
| Mouse chromosome position | 7 50.0 cM |
|---|
| GO ID | 0005096 |
|---|---|
| 0031701 | |
| 0004857 | |
| 0004402 | |
| 0005159 | |
| 0010843 | |
| 0008134 | |
| 0031625 | |
| 0002031 | |
| 0016044 | |
| 0043967 | |
| 0032088 | |
| 0032715 | |
| 0032717 | |
| 0031397 | |
| 0009968 | |
| 0007602 | |
| 0070374 | |
| 0035025 | |
| 0010552 | |
| 0035066 | |
| 0006892 | |
| 0043161 | |
| 0015031 | |
| 0016567 | |
| 0008277 | |
| 0045449 | |
| 0007600 | |
| 0043149 | |
| 0006366 | |
| 0000785 | |
| 0005905 | |
| 0005737 | |
| 0016023 | |
| 0031410 | |
| 0005834 | |
| 0005622 | |
| 0005624 | |
| 0005634 | |
| 0005886 | |
| 0031143 | |
| 0005625 | |
| 0051219 | |
| 0007186 | |
| 0000187 | |
| 0006897 | |
| 0045944 | |
| 0007165 | |
| 0006350 | |
| 0006810 | |
| 0042995 | |
| 0005829 | |
| 0016020 | |
| 0045211 | |
| 0001664 | |
| 0030276 | |
| 0007188 | |
| 0002032 | |
| 0030817 | |
| 0030820 | |
| 0019233 | |
| 0050975 | |
| 0005515 | |
| 0050896 |
| Rat chromosome position | 1q32 |
|---|
| Swiss-Prot Accession | P49407 |
|---|---|
| Q8BWG8 | |
| Q3U172 | |
| P29066 | |
| B6V9G8 | |
| O75625 | |
| O75630 | |
| Q2PP20 | |
| Q9BTK8 | |
| Q3UH95 | |
| Q8BTJ5 |
| PIR ID | B46682 |
|---|---|
| B43404 |
| Unigene ID | Hs.503284 |
|---|---|
| Hs.625320 | |
| Mm.260193 | |
| Rn.34876 |
| KEGG ID | hsa:408 |
|---|---|
| mmu:109689 | |
| rno:25387 |
| Swiss-Prot ID | ARRB1_HUMAN |
|---|---|
| ARRB1_RAT | |
| ARRB1_MOUSE | |
| B6V9G8_HUMAN |
| Cell Localization | Cytoplasm |
|---|---|
| Nucleus | |
| Cell membrane | |
| Membrane | |
| clathrin-coated pit | |
| Cell projection | |
| pseudopodium | |
| Cytoplasmic vesicle |
| IPI ID | IPI00293857 |
|---|---|
| IPI00336017 | |
| IPI00200580 | |
| IPI00274186 | |
| IPI00761566 | |
| IPI00777900 | |
| IPI00781876 |
| Homologene ID | 2981 |
|---|
| RGD ID | 2156 |
|---|
| MGI ID | 99473 |
|---|