Ariadne Genomics Inc. Pth --+> Ca2+ reabsorption Pth ---> anabolic, catabolic effects on bone phosphate reabsoprtion activation of adenylyl cyclases/increased cAMP --+> protein kinase A (PKA) signaling pathway cAMP increased DAG/IP3 via PLC activation --+> protein kinase C (PKC) signaling pathway IP3 DAG Slc34a1 phosphate transport pathway anabolic, catabolic effects on bone Pth1r partners G protein mediated signaling pathway via Galphas family ---> activation of adenylyl cyclases/increased cAMP Arrb1 ---- Pth1r Arrb2 ---- Pth1r Arrb1 Adrbk1 Pth1r ---- Pth1r partners Pth1r ---- Slc9a3r2 Slc9a3r2 Ezr ---- Pth1r Ezr Ezr ---- Slc9a3r1 Pth1r ---- Slc9a3r1 Slc9a3r1 calcium signaling pathway via the calcium-sensing receptor ---| Pth protein kinase A (PKA) signaling pathway G protein mediated signaling pathway via Galphaq family activation of adenylyl cyclases/increased cAMP protein kinase C (PKC) signaling pathway Adrbk1 ---| Pth1r Arrb2 Ca2+ G protein mediated signaling pathway via Galphaq family ---> increased DAG/IP3 via PLC activation Pth ---- Pth1r Ca2+ --+> Pth calcium signaling pathway via the calcium-sensing receptor Ca2+ --+> calcium signaling pathway via the calcium-sensing receptor increased DAG/IP3 via PLC activation Pth ---| phosphate reabsoprtion Pth ---| phosphate transport pathway Pth Ca2+ reabsorption Slc34a1 ---- Slc9a3r1 Pth1r --+> G protein mediated signaling pathway via Galphas family Pth1r Pth1r --+> G protein mediated signaling pathway via Galphaq family G protein mediated signaling pathway via Galphas family