| URN | urn:agi-llid:2321 |
|---|---|
| Connectivity | 466 |
| Name | Flt1 |
| Description | FMS-like tyrosine kinase 1 |
| Notes | tyrosine kinase receptor for vascular endothelial growth factor; may play a role in cell proliferation and cell survival [RGD] |
| Pathway | VEGFR -> AP-1/CREB/MYC signaling |
|---|---|
| VEGFR -> FOXO3A signaling | |
| VEGFR -> CTNNB signaling | |
| VEGFR -> ATF/CREB/ELK-SRF signaling | |
| vascular endothelial growth factor signaling pathway | |
| New Pathway (2) | |
| axitinib pharmacodynamics pathway |
| GO Molecular Function | nucleotide binding |
|---|---|
| transferase activity | |
| growth factor binding | |
| ATP binding | |
| kinase activity | |
| protein kinase activity | |
| protein tyrosine kinase activity | |
| receptor signaling protein tyrosine kinase activity | |
| transmembrane receptor protein tyrosine kinase activity | |
| vascular endothelial growth factor receptor activity | |
| receptor activity |
| GO Cellular Component | extracellular region |
|---|---|
| membrane | |
| extracellular space | |
| plasma membrane | |
| cytoplasm | |
| integral to membrane | |
| integral to plasma membrane |
| GO Biological Process | positive regulation of cell proliferation |
|---|---|
| multicellular organismal development | |
| female pregnancy | |
| patterning of blood vessels | |
| cell differentiation | |
| angiogenesis | |
| sprouting angiogenesis | |
| regulation of smooth muscle contraction | |
| positive regulation of vascular endothelial growth factor receptor signaling pathway | |
| activation of MAPKK activity | |
| positive regulation of smooth muscle cell proliferation | |
| positive regulation of fibroblast proliferation | |
| positive regulation of cell migration | |
| cell migration | |
| protein amino acid phosphorylation | |
| peptidyl-tyrosine phosphorylation | |
| response to hypoxia | |
| intracellular receptor mediated signaling pathway | |
| transmembrane receptor protein tyrosine kinase signaling pathway | |
| vascular endothelial growth factor receptor signaling pathway |
| Ariadne Ontology | GFR |
|---|
| Group | GFR |
|---|---|
| extracellular region | |
| positive regulation of cell proliferation | |
| multicellular organismal development | |
| female pregnancy | |
| patterning of blood vessels | |
| cell differentiation | |
| angiogenesis | |
| sprouting angiogenesis | |
| regulation of smooth muscle contraction | |
| positive regulation of vascular endothelial growth factor receptor signaling pathway | |
| activation of MAPKK activity | |
| positive regulation of smooth muscle cell proliferation | |
| positive regulation of fibroblast proliferation | |
| positive regulation of cell migration | |
| cell migration | |
| protein amino acid phosphorylation | |
| peptidyl-tyrosine phosphorylation | |
| response to hypoxia | |
| intracellular receptor mediated signaling pathway | |
| transmembrane receptor protein tyrosine kinase signaling pathway | |
| vascular endothelial growth factor receptor signaling pathway | |
| nucleotide binding | |
| transferase activity | |
| growth factor binding | |
| ATP binding | |
| kinase activity | |
| protein kinase activity | |
| protein tyrosine kinase activity | |
| receptor signaling protein tyrosine kinase activity | |
| transmembrane receptor protein tyrosine kinase activity | |
| vascular endothelial growth factor receptor activity | |
| receptor activity | |
| membrane | |
| extracellular space | |
| plasma membrane | |
| cytoplasm | |
| integral to membrane | |
| integral to plasma membrane |
| MedScan ID | 2321 |
|---|
| Hugo ID | 3763 |
|---|
| Human chromosome position | 13q12 |
|---|
| LocusLink ID | 2321 |
|---|---|
| 14254 | |
| 54251 | |
| 100598 |
| Alias | FLT |
|---|---|
| VEGFR1 | |
| vascular endothelial growth factor receptor 1 | |
| FLT-1 | |
| VEGFR-1 | |
| fms-like tyrosine kinase 1 | |
| tyrosine-protein kinase FRT | |
| tyrosine-protein kinase receptor FLT | |
| vascular permeability factor receptor | |
| sFlt1 | |
| AI323757 | |
| OTTMUSP00000023727 | |
| embryonic receptor kinase 2 | |
| vascular endothelial growth factor receptor-1 | |
| Fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) | |
| FRT | |
| Flt I | |
| Flt1 | |
| FMS-like tyrosine kinase I | |
| fms-related tyrosine kinase 1 | |
| fms-related tyrosine kinase I | |
| sFlt I | |
| soluble VEGF receptor 1-14 | |
| soluble VEGFR1 variant 2 | |
| soluble VEGFR1 variant 21 | |
| Tyrosine- protein kinase FRT | |
| Vascular endothelial growth factor receptor I | |
| vascular endothelial growth factor/vascular permeability factor receptor | |
| Vascular permeability factor receptors | |
| VEGF receptor 1 | |
| VEGF receptor I | |
| VEGFR I | |
| VEGF-R1 | |
| VGR1_HUMAN | |
| vascular endothelial growth factor receptor | |
| VEGF receptor | |
| Vascular endothelial growth factor precursor receptors | |
| Vascular permeability factor receptors | |
| VEGF receptors | |
| VEGFR-1s | |
| VEGFR Is |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 165070 |
|---|
| Mouse chromosome position | 5 82.0 cM |
|---|
| GO ID | 0005524 |
|---|---|
| 0019838 | |
| 0000166 | |
| 0004872 | |
| 0016740 | |
| 0004714 | |
| 0005021 | |
| 0000186 | |
| 0001525 | |
| 0030154 | |
| 0007565 | |
| 0030522 | |
| 0007275 | |
| 0018108 | |
| 0030335 | |
| 0008284 | |
| 0048661 | |
| 0030949 | |
| 0006940 | |
| 0001666 | |
| 0007169 | |
| 0005737 | |
| 0005576 | |
| 0005615 | |
| 0005887 | |
| 0005886 | |
| 0016301 | |
| 0004672 | |
| 0004713 | |
| 0016477 | |
| 0001569 | |
| 0048146 | |
| 0006468 | |
| 0002040 | |
| 0048010 | |
| 0016021 | |
| 0016020 | |
| 0004716 | |
| 0042802 | |
| 0004674 |
| Rat chromosome position | 12p11 |
|---|
| Swiss-Prot Accession | P17948 |
|---|---|
| B3FR89 | |
| B5A923 | |
| B0LPF1 | |
| Q16332 | |
| Q16333 | |
| Q59GQ9 | |
| P35969 | |
| O55095 | |
| Q3TJC1 | |
| Q5GRG7 | |
| Q78ZF4 | |
| Q8K1H4 | |
| Q9CSC8 | |
| Q9CW58 | |
| Q9DAV2 | |
| P53767 | |
| Q9JJ08 | |
| O55094 | |
| Q61517 | |
| A8KA71 | |
| O60722 | |
| P16057 | |
| Q12954 | |
| Q5TAR1 |
| PIR ID | I78875 |
|---|---|
| S49010 | |
| A49636 | |
| S09982 | |
| I60598 |
| Unigene ID | Hs.594454 |
|---|---|
| Mm.389712 | |
| Rn.10239 | |
| Hs.654360 | |
| Hs.507621 | |
| Mm.3464 |
| KEGG ID | hsa:2321 |
|---|---|
| mmu:14254 | |
| rno:54251 |
| EC Number | 2.7.10.1 |
|---|---|
| 2.7.1.112 |
| Swiss-Prot ID | VGFR1_MOUSE |
|---|---|
| VGFR1_HUMAN | |
| VGFR1_RAT | |
| B0LPF1_HUMAN | |
| B3FR89_HUMAN | |
| B5A923_HUMAN |
| Cell Localization | Membrane |
|---|---|
| Cell membrane | |
| Secreted | |
| Plasma membrane |
| IPI ID | IPI00124497 |
|---|---|
| IPI00018335 | |
| IPI00216043 | |
| IPI00212864 | |
| IPI00930254 | |
| IPI00930300 | |
| IPI00815971 | |
| IPI00816497 | |
| IPI00551339 | |
| IPI00119072 | |
| IPI00779044 |
| Homologene ID | 20463 |
|---|
| RGD ID | 2621 |
|---|
| MGI ID | 95558 |
|---|---|
| 2140833 |
| KEGG pathway | Cytokine-cytokine receptor interaction |
|---|---|
| Focal adhesion |