| URN | urn:agi-llid:1575 |
|---|---|
| Connectivity | 297 |
| Name | CYP3A4 |
| Description | cytochrome P450, family 3, subfamily A, polypeptide 4 |
| Notes | This gene, CYP3A4, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs which are are used today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4. |
| Pathway | nateglinide pharmacokinetics pathway |
|---|---|
| repaglinide pharmacokinetics pathway | |
| statin pharmacokinetics pathway | |
| tamoxifen pharmacokinetics pathway | |
| gefitinib pharmacokinetics pathway | |
| axitinib pharmacokinetics pathway |
| GO Molecular Function | electron carrier activity |
|---|---|
| oxygen binding | |
| oxidoreductase activity | |
| demethylase activity | |
| enzyme binding | |
| steroid binding | |
| heme binding | |
| metal ion binding | |
| iron ion binding | |
| monooxygenase activity | |
| vitamin D 24-hydroxylase activity | |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | |
| vitamin D3 25-hydroxylase activity | |
| steroid hydroxylase activity | |
| aromatase activity | |
| albendazole monooxygenase activity | |
| taurochenodeoxycholate 6alpha-hydroxylase activity | |
| quinine 3-monooxygenase activity | |
| testosterone 6-beta-hydroxylase activity | |
| caffeine oxidase activity |
| GO Cellular Component | cell surface |
|---|---|
| membrane | |
| cytoplasm | |
| endoplasmic reticulum membrane | |
| endoplasmic reticulum | |
| microsome | |
| integral to membrane |
| GO Biological Process | aging |
|---|---|
| oxidation reduction | |
| drug metabolic process | |
| heterocycle metabolic process | |
| androgen metabolic process | |
| drug catabolic process | |
| alkaloid catabolic process | |
| monoterpenoid metabolic process | |
| oxidative demethylation | |
| exogenous drug catabolic process | |
| response to drug | |
| response to nutrient | |
| response to metal ion | |
| response to cadmium ion | |
| response to glucocorticoid stimulus | |
| lipid metabolic process | |
| steroid metabolic process | |
| steroid catabolic process | |
| vitamin D metabolic process |
| Ariadne Ontology | Xenobiotic clearance |
|---|
| Group | Xenobiotic clearance |
|---|---|
| electron carrier activity | |
| aging | |
| oxidation reduction | |
| drug metabolic process | |
| heterocycle metabolic process | |
| androgen metabolic process | |
| drug catabolic process | |
| alkaloid catabolic process | |
| monoterpenoid metabolic process | |
| oxidative demethylation | |
| exogenous drug catabolic process | |
| response to drug | |
| response to nutrient | |
| response to metal ion | |
| response to cadmium ion | |
| response to glucocorticoid stimulus | |
| lipid metabolic process | |
| steroid metabolic process | |
| steroid catabolic process | |
| vitamin D metabolic process | |
| oxygen binding | |
| oxidoreductase activity | |
| demethylase activity | |
| enzyme binding | |
| steroid binding | |
| heme binding | |
| metal ion binding | |
| iron ion binding | |
| monooxygenase activity | |
| vitamin D 24-hydroxylase activity | |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | |
| vitamin D3 25-hydroxylase activity | |
| steroid hydroxylase activity | |
| aromatase activity | |
| albendazole monooxygenase activity | |
| taurochenodeoxycholate 6alpha-hydroxylase activity | |
| quinine 3-monooxygenase activity | |
| testosterone 6-beta-hydroxylase activity | |
| caffeine oxidase activity | |
| cell surface | |
| membrane | |
| cytoplasm | |
| endoplasmic reticulum membrane | |
| endoplasmic reticulum | |
| microsome | |
| integral to membrane |
| MedScan ID | 1575 |
|---|
| Hugo ID | 2637 |
|---|
| Human chromosome position | 7q21.1 |
|---|
| LocusLink ID | 1575 |
|---|---|
| 1576 | |
| 13112 | |
| 13114 | |
| 53973 | |
| 337924 | |
| 100041375 | |
| 25642 | |
| 266682 |
| Alias | HLP |
|---|---|
| CP33 | |
| CP34 | |
| CYP3A | |
| NF-25 | |
| CYP3A3 | |
| P450C3 | |
| P450PCN1 | |
| MGC126680 | |
| cytochrome P450 3A4 | |
| CYPIIIA3 | |
| CYPIIIA4 | |
| nifedipine oxidase | |
| cytochrome P450 3A3 | |
| cytochrome P450 HLp | |
| cytochrome P450-PCN1 | |
| cytochrome P450 NF-25 | |
| albendazole sulfoxidase | |
| quinine 3-monooxygenase | |
| albendazole monooxygenase | |
| P450-III, steroid inducible | |
| glucocorticoid-inducible P450 | |
| taurochenodeoxycholate 6-alpha-hydroxylase | |
| cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 3 | |
| cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4 | |
| Pcn | |
| IIIAm1 | |
| AI256190 | |
| cytochrome P450 3A11 | |
| CYPIIIA11 | |
| steroid inducible | |
| OTTMUSP00000031951 | |
| cytochrome P-450UT | |
| cytochrome P-450IIIAM1 | |
| cytochrome P450, steroid inducible 3a11 | |
| MGC130513 | |
| cytochrome P450 3A16 | |
| CYPIIIA16 | |
| OTTMUSP00000030399 | |
| cytochrome P450, 3a16 | |
| Cyp3a41 | |
| Cyp3a41b | |
| cytochrome P450 3A41 | |
| cytochrome P450, steroid inducible 3a41 | |
| cytochrome P450, family 3, subfamily a, polypeptide 41 | |
| cytochrome P450, family 3, subfamily a, polypeptide 44 | |
| OTTMUSP00000030400 | |
| cytochrome P450, 3a44 | |
| Cyp3a41a | |
| CYP | |
| RL33 | |
| cDEX | |
| Cyp3a1 | |
| CYP3A23 | |
| MGC108757 | |
| cytochrome P450 3A1 | |
| CYPIIIA1 | |
| P450 IIIA | |
| P450-PCN1 | |
| cytochrome P450/6 beta B | |
| cytochrome P-450PCN (PNCN inducible) | |
| cytochrome P450, subfamily 3A, polypeptide 3 | |
| Cytochrome P450, subfamily IIIA, polypeptide 3 | |
| cytochrome P450, family 3, subfamily a, polypeptide 1 | |
| Cyp3a11 | |
| MGC108545 | |
| cytochrome P450 3A2 | |
| CYPIIIA2 | |
| P450-PCN2 | |
| P450/6-beta-A | |
| cytochrome P450-PCN2 | |
| cytochrome P450/6-beta-A | |
| testosterone 6-beta-hydroxylase | |
| cytochrome P450, family 3, subfamily a, polypeptide 11 | |
| Cyp3a-11 | |
| Cyp3a23/3a1 | |
| C230004D03 | |
| C230004D03Rik | |
| Cyp3a16 | |
| CYP3a2 | |
| Cyp3a21 | |
| CYP3A4 | |
| Cyp3a44 | |
| CYPSA4 | |
| cytochrome P450 3A21 | |
| cytochrome P450 3a23/1 | |
| cytochrome P450 3a23/3a1 | |
| cytochrome P450 3a41a | |
| cytochrome P450 3a41b | |
| cytochrome P450 3a44 | |
| cytochrome P450 IIIA III | |
| cytochrome P450 IIIA IV | |
| cytochrome P450 IIIA niphedipine oxidase 3 | |
| cytochrome P450 IIIA niphedipine oxidase 4 | |
| cytochrome P450 IIIA niphedipine oxidase III | |
| cytochrome P450 IIIA niphedipine oxidase IV | |
| cytochrome P450 IIIA3 | |
| cytochrome P450 IIIA4 | |
| cytochrome P4503a11 | |
| cytochrome P4503a16 | |
| cytochrome P4503a2 | |
| cytochrome P4503A21 | |
| cytochrome P4503a23/1 | |
| cytochrome P4503a23/3a1 | |
| cytochrome P4503A3 | |
| cytochrome P4503A4 | |
| cytochrome P4503a41 | |
| cytochrome P4503a41a | |
| cytochrome P4503a41b | |
| cytochrome P4503a44 | |
| E330004N01 | |
| FLJ11220 | |
| IIIAm I | |
| IIIAm2 | |
| MGC93139 | |
| mKIAA3002 | |
| olfactory cytochrome P450olf3 | |
| P450 (CYP) 3a11 | |
| P450 (CYP) 3a16 | |
| P450 (CYP) 3a2 | |
| P450 (CYP) 3A21 | |
| P450 (CYP) 3a23/1 | |
| P450 (CYP) 3a23/3a1 | |
| P450 (CYP) 3A3 | |
| P450 (CYP) 3A4 | |
| P450 (CYP) 3a41 | |
| P450 (CYP) 3a41a | |
| P450 (CYP) 3a41b | |
| P450 (CYP) 3a44 | |
| P450 (CYP) IIIa | |
| P450 3a11 | |
| P450 3a16 | |
| P450 3a2 | |
| P450 3A21 | |
| P450 3a23/1 | |
| P450 3a23/3a1 | |
| P450 3A3 | |
| P450 3A4 | |
| P450 3a41 | |
| P450 3a41a | |
| P450 3a41b | |
| P450 3a44 | |
| P4503a11 | |
| P4503a16 | |
| P4503a2 | |
| P4503A21 | |
| P4503a23/1 | |
| P4503a23/3a1 | |
| P4503A3 | |
| P4503A4 | |
| P4503a41 | |
| P4503a41a | |
| P4503a41b | |
| P4503a44 | |
| P450olf3 | |
| P450PCN I | |
| RL(33) | |
| cytochrome P450, family 3, subfamily A, polypeptide 4 | |
| cytochrome P450, family 3, subfamily a, polypeptide 16 | |
| cytochrome P450, family 3, subfamily a, polypeptide 41A | |
| cytochrome P450, family 3, subfamily a, polypeptide 41B | |
| cytochrome P450, family 3, subfamily a, polypeptide 23/polypeptide 1 | |
| cytochrome P450, family 3, subfamily a, polypeptide 2 | |
| cytochrome P450, family 3, subfamily a, polypeptide 13 | |
| 8430412F05 | |
| RIKEN cDNA C230004D03 gene | |
| cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide IV | |
| cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide III | |
| Cytochrome P450, subfamily IIIA, polypeptide III | |
| Cyp3a13 | |
| cytochrome P450, subfamily IIIA, polypeptide IV | |
| cytochrome P450, subfamily IIIA, polypeptide 4 | |
| IIIAm2s | |
| IIIAm1s | |
| CYP3A9 | |
| hypothetical protein 8430412F05 | |
| hypothetical protein FLJ11220 | |
| Cytochrome P450 3A21 (CYPIIIA21) (P450 CM3A-10) | |
| cytochrome P450 3A9 | |
| RL 33 | |
| RL-33 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 124010 |
|---|
| Mouse chromosome position | 5 85.0 cM |
|---|---|
| 5 | |
| 5 G2 |
| GO ID | 0047638 |
|---|---|
| 0034875 | |
| 0009055 | |
| 0019899 | |
| 0020037 | |
| 0005506 | |
| 0046872 | |
| 0004497 | |
| 0016491 | |
| 0016712 | |
| 0019825 | |
| 0050591 | |
| 0005496 | |
| 0008395 | |
| 0033780 | |
| 0050649 | |
| 0070576 | |
| 0030343 | |
| 0009822 | |
| 0008209 | |
| 0042737 | |
| 0017144 | |
| 0042738 | |
| 0046483 | |
| 0006629 | |
| 0016098 | |
| 0055114 | |
| 0070989 | |
| 0006706 | |
| 0008202 | |
| 0042359 | |
| 0009986 | |
| 0005737 | |
| 0005783 | |
| 0005789 | |
| 0016021 | |
| 0016020 | |
| 0005792 | |
| 0070330 | |
| 0032451 | |
| 0007568 | |
| 0046686 | |
| 0042493 | |
| 0051384 | |
| 0010038 | |
| 0007584 | |
| 0003674 | |
| 0008150 | |
| 0005575 | |
| 0006805 | |
| 0005624 | |
| 0050381 | |
| 0005615 |
| Rat chromosome position | 12p11 |
|---|
| Swiss-Prot Accession | P08684 |
|---|---|
| Q6GRK0 | |
| Q7Z448 | |
| Q86SK2 | |
| Q86SK3 | |
| Q9BZM0 | |
| Q3UEN8 | |
| Q64459 | |
| Q52L54 | |
| Q2KHL4 | |
| Q64481 | |
| Q9JMA7 | |
| Q9EQW4 | |
| Q06884 | |
| P04800 | |
| Q64590 | |
| Q6LEQ2 | |
| P05183 | |
| Q5FVU5 | |
| Q64629 | |
| Q64672 | |
| P05184 | |
| Q16757 | |
| Q9UK50 |
| PIR ID | A25222 |
|---|---|
| S22334 | |
| A29410 | |
| A29815 | |
| A26997 | |
| C26997 | |
| JX0334 |
| Unigene ID | Hs.111944 |
|---|---|
| Mm.332844 | |
| Mm.378905 | |
| Mm.379071 | |
| Mm.425301 | |
| Rn.91120 | |
| Hs.654391 |
| KEGG ID | hsa:1576 |
|---|---|
| mmu:13112 | |
| mmu:13114 | |
| mmu:53973 | |
| mmu:337924 | |
| mmu:100041375 | |
| rno:25642 | |
| rno:266682 |
| EC Number | 1.14.13.97 |
|---|---|
| 1.14.13.32 | |
| 1.14.13.67 | |
| 1.14.14.1 |
| Swiss-Prot ID | CP3A2_RAT |
|---|---|
| CP3AB_MOUSE | |
| CP3A4_HUMAN | |
| Q06884_RAT | |
| Q9EQW4_MOUSE | |
| Q2KHL4_MOUSE | |
| Q6GRK0_HUMAN | |
| Q3UEN8_MOUSE |
| Cell Localization | Endoplasmic reticulum membrane |
|---|---|
| Microsome membrane | |
| Plasma membrane |
| IPI ID | IPI00196764 |
|---|---|
| IPI00134504 | |
| IPI00465138 | |
| IPI00324932 | |
| IPI00111634 | |
| IPI00134550 | |
| IPI00479050 | |
| IPI00125340 | |
| IPI00199589 |
| RGD ID | 1352962 |
|---|
| MGI ID | 88609 |
|---|---|
| 106099 | |
| 1858451 | |
| 2449818 | |
| 3714859 |