| URN | urn:agi-llid:1577 |
|---|---|
| Connectivity | 62 |
| Name | CYP3A5 |
| Description | cytochrome P450, family 3, subfamily A, polypeptide 5 |
| Notes | This gene,CYP3A5, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. The enzyme metabolizes drugs such as nifedipine and cyclosporine as well as the steroid hormones testosterone, progesterone and androstenedione. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. This cluster includes a pseudogene, CYP3A5P1, which is very similar to CYP3A5. This similarity has caused some difficulty in determining whether cloned sequences represent the gene or the pseudogene. Multiple alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq] |
| Pathway | gefitinib pharmacokinetics pathway |
|---|---|
| axitinib pharmacokinetics pathway |
| GO Molecular Function | electron carrier activity |
|---|---|
| oxygen binding | |
| oxidoreductase activity | |
| heme binding | |
| metal ion binding | |
| monooxygenase activity | |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | |
| aromatase activity |
| GO Cellular Component | membrane |
|---|---|
| endoplasmic reticulum membrane | |
| endoplasmic reticulum | |
| microsome |
| GO Biological Process | oxidation reduction |
|---|---|
| drug catabolic process | |
| alkaloid catabolic process | |
| oxidative demethylation | |
| steroid metabolic process |
| Group | electron carrier activity |
|---|---|
| oxidation reduction | |
| drug catabolic process | |
| alkaloid catabolic process | |
| oxidative demethylation | |
| steroid metabolic process | |
| oxygen binding | |
| oxidoreductase activity | |
| heme binding | |
| metal ion binding | |
| monooxygenase activity | |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | |
| aromatase activity | |
| membrane | |
| endoplasmic reticulum membrane | |
| endoplasmic reticulum | |
| microsome |
| MedScan ID | 1577 |
|---|
| Hugo ID | 2638 |
|---|
| Human chromosome position | 7q21.1 |
|---|
| LocusLink ID | 1577 |
|---|---|
| 498198 |
| Alias | CP35 |
|---|---|
| PCN3 | |
| FLJ31317 | |
| P450PCN3 | |
| DKFZp686L16231 | |
| cytochrome P450 3A5 | |
| CYPIIIA5 | |
| cytochrome P-450 | |
| niphedipine oxidase | |
| cytochrome P450 HLp2 | |
| cytochrome P450-PCN3 | |
| microsomal monooxygenase | |
| xenobiotic monooxygenase | |
| aryl hydrocarbon hydroxylase | |
| flavoprotein-linked monooxygenase | |
| cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 5 | |
| cytochrome P450, family 3, subfamily a, polypeptide 73 | |
| 3A-25 | |
| CYP3A5 | |
| Cyp3a73 | |
| cytochrome P450 3a73 | |
| cytochrome P450 IIIA niphedipine oxidase 5 | |
| cytochrome P450 IIIA niphedipine oxidase V | |
| cytochrome P450 IIIA V | |
| cytochrome P450 IIIA5 | |
| cytochrome P4503A5 | |
| cytochrome P4503a73 | |
| LOC288460 | |
| OTTMUSP00000026286 | |
| P450 (CYP) 3A5 | |
| P450 (CYP) 3a73 | |
| P450 3A5 | |
| P450 3a73 | |
| P450(6)beta-2 | |
| P4503A5 | |
| P4503a73 |
| Organism | Homo sapiens |
|---|---|
| Rattus norvegicus |
| OMIM ID | 605325 |
|---|---|
| 145500 |
| GO ID | 0070330 |
|---|---|
| 0009055 | |
| 0020037 | |
| 0046872 | |
| 0004497 | |
| 0016491 | |
| 0019825 | |
| 0009822 | |
| 0042737 | |
| 0070989 | |
| 0008202 | |
| 0005783 | |
| 0005789 | |
| 0016020 | |
| 0005792 | |
| 0016712 | |
| 0055114 |
| Rat chromosome position | 12 |
|---|
| Swiss-Prot Accession | P20815 |
|---|---|
| Q14V85 | |
| Q53GC3 | |
| Q7Z3N0 | |
| Q7Z446 | |
| Q7Z447 | |
| Q86SK1 | |
| Q96RK6 | |
| Q96RK8 | |
| A4D289 | |
| Q53WY8 | |
| Q75MV0 | |
| Q9HB56 |
| PIR ID | A34101 |
|---|---|
| A60558 |
| Unigene ID | Hs.695915 |
|---|
| KEGG ID | hsa:1577 |
|---|---|
| rno:498198 |
| EC Number | 1.14.14.1 |
|---|
| Swiss-Prot ID | CP3A5_HUMAN |
|---|---|
| CP3AD_MOUSE | |
| A4D289_HUMAN | |
| Q3UW87_MOUSE | |
| Q5PQX2_RAT |
| Cell Localization | Endoplasmic reticulum membrane |
|---|---|
| Microsome membrane |
| IPI ID | IPI00025831 |
|---|---|
| IPI00385009 | |
| IPI00854876 | |
| IPI00815862 | |
| IPI00134519 | |
| IPI00325855 | |
| IPI00844833 | |
| IPI00560973 |
| Homologene ID | 121494 |
|---|
| RGD ID | 1348646 |
|---|