Protein CYP2C19

URN	urn:agi-llid:1557
Connectivity	133
Name	CYP2C19
Description	cytochrome P450, family 2, subfamily C, polypeptide 19
Notes	This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, omeprazole, diazepam and some barbiturates. Polymorphism within this gene is associated with variable ability to metabolize mephenytoin, known as the poor metabolizer and extensive metabolizer phenotypes. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. [provided by RefSeq]

Pathway	axitinib pharmacokinetics pathway

GO Molecular Function	electron carrier activity
	oxygen binding
	oxidoreductase activity
	enzyme binding
	heme binding
	metal ion binding
	iron ion binding
	monooxygenase activity
	steroid hydroxylase activity
	aromatase activity
	4-hydroxyacetophenone monooxygenase activity
	(S)-limonene 6-monooxygenase activity
	(S)-limonene 7-monooxygenase activity

GO Cellular Component	membrane
	endoplasmic reticulum membrane
	endoplasmic reticulum
	microsome

GO Biological Process	oxidation reduction
	drug metabolic process
	heterocycle metabolic process
	monoterpenoid metabolic process
	exogenous drug catabolic process
	steroid metabolic process

Ariadne Ontology	Leukotriene synthesis

Group	Leukotriene synthesis
	electron carrier activity
	oxidation reduction
	drug metabolic process
	heterocycle metabolic process
	monoterpenoid metabolic process
	exogenous drug catabolic process
	steroid metabolic process
	oxygen binding
	oxidoreductase activity
	enzyme binding
	heme binding
	metal ion binding
	iron ion binding
	monooxygenase activity
	steroid hydroxylase activity
	aromatase activity
	4-hydroxyacetophenone monooxygenase activity
	(S)-limonene 6-monooxygenase activity
	(S)-limonene 7-monooxygenase activity
	membrane
	endoplasmic reticulum membrane
	endoplasmic reticulum
	microsome

MedScan ID	1557

Hugo ID	2621

Human chromosome position	10q24.1-q24.3

Alias	CPCJ
	CYP2C
	P450C2C
	P450IIC19
	RP11-400G3.4
	cytochrome P450 2C19
	CYPIIC17
	CYPIIC19
	cytochrome P450-11A
	cytochrome P450-254C
	cytochrome P-450 II C
	microsomal monooxygenase
	xenobiotic monooxygenase
	mephenytoin 4-hydroxylase
	mephenytoin 4'-hydroxylase
	S-mephenytoin 4-hydroxylase
	(R)-limonene 6-monooxygenase
	(S)-limonene 6-monooxygenase
	(S)-limonene 7-monooxygenase
	flavoprotein-linked monooxygenase
	cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 19
	cytochrome P450 2C37
	CYPIIC37
	cytochrome P450, 2c37
	AI266900
	cytochrome P450 2C50
	CYPIIC50
	cytochrome P450, 2c50
	EG404195
	cytochrome P450 2C54
	CYPIIC54
	cytochrome P450, family 2, subfamily c, polypeptide 37
	MGC109053
	cytochrome P450-like
	Ahh I
	Ahh-1
	AHOH
	AHOHase
	AHOHases
	AI159681
	AI196010
	CYP2C19
	Cyp2c37
	Cyp2c50
	Cyp2c54
	cytochrome P450 IIC mephenytoin 4-hydroxylase 19
	cytochrome P-450 S-mephenytoin 4-hydroxylase
	cytochrome P4502C19
	cytochrome P4502c37
	cytochrome P4502c50
	cytochrome P4502c54
	LOC226104
	LOC361754
	MGC156667
	OTTHUMP00000020132
	OTTHUMP00000059588
	P450 (CYP) 2C19
	P450 (CYP) 2c37
	P450 (CYP) 2c50
	P450 (CYP) 2c54
	P450 2C19
	P450 2c37
	P450 2c50
	P450 2c54
	P450-11A
	P450-254C
	P4502C19
	P4502c37
	P4502c50
	P4502c54
	P450pb1

OMIM ID	124020
	609535

Mouse chromosome position	19

Rat chromosome position	1q52
	1q53

Cell Localization	Endoplasmic reticulum membrane
	Microsome membrane
	Plasma membrane

RGD ID	737416