Protein CYP1A2

URN	urn:agi-llid:1544
Connectivity	189
Name	CYP1A2
Description	cytochrome P450, family 1, subfamily A, polypeptide 2
Notes	This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. Other xenobiotic substrates for this enzyme include caffeine, aflatoxin B1, and acetaminophen. The transcript from this gene contains four Alu sequences flanked by direct repeats in the 3' untranslated region. [provided by RefSeq]

Pathway	axitinib pharmacokinetics pathway

GO Molecular Function	electron carrier activity
	oxygen binding
	oxidoreductase activity
	demethylase activity
	enzyme binding
	heme binding
	metal ion binding
	iron ion binding
	monooxygenase activity
	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
	aromatase activity
	caffeine oxidase activity

GO Cellular Component	membrane
	endoplasmic reticulum membrane
	endoplasmic reticulum
	microsome

GO Biological Process	post-embryonic development
	oxidation reduction
	response to stress
	lung development
	xenobiotic metabolic process
	drug metabolic process
	toxin metabolic process
	cellular aromatic compound metabolic process
	heterocycle metabolic process
	toxin biosynthetic process
	dibenzo-p-dioxin metabolic process
	porphyrin metabolic process
	drug catabolic process
	hydrogen peroxide biosynthetic process
	monocarboxylic acid metabolic process
	cellular respiration
	monoterpenoid metabolic process
	oxidative demethylation
	exogenous drug catabolic process
	response to organic substance
	response to drug
	response to organic cyclic substance
	response to lipopolysaccharide
	response to estradiol stimulus
	regulation of gene expression
	alkaloid metabolic process
	oxidative deethylation
	steroid catabolic process

Ariadne Ontology	Aromatic amino acid metabolism

Group	Aromatic amino acid metabolism
	electron carrier activity
	post-embryonic development
	oxidation reduction
	response to stress
	lung development
	xenobiotic metabolic process
	drug metabolic process
	toxin metabolic process
	cellular aromatic compound metabolic process
	heterocycle metabolic process
	toxin biosynthetic process
	dibenzo-p-dioxin metabolic process
	porphyrin metabolic process
	drug catabolic process
	hydrogen peroxide biosynthetic process
	monocarboxylic acid metabolic process
	cellular respiration
	monoterpenoid metabolic process
	oxidative demethylation
	exogenous drug catabolic process
	response to organic substance
	response to drug
	response to organic cyclic substance
	response to lipopolysaccharide
	response to estradiol stimulus
	regulation of gene expression
	alkaloid metabolic process
	oxidative deethylation
	steroid catabolic process
	oxygen binding
	oxidoreductase activity
	demethylase activity
	enzyme binding
	heme binding
	metal ion binding
	iron ion binding
	monooxygenase activity
	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
	aromatase activity
	caffeine oxidase activity
	membrane
	endoplasmic reticulum membrane
	endoplasmic reticulum
	microsome

MedScan ID	1544

Hugo ID	2596

Human chromosome position	15q24.1

Alias	CP12
	P3-450
	P450(PA)
	cytochrome P450 1A2
	CYPIA2
	P450 form 4
	cytochrome P450 4
	cytochrome P(3)450
	cytochrome P450-P3
	dioxin-inducible P3-450
	microsomal monooxygenase
	xenobiotic monooxygenase
	aryl hydrocarbon hydroxylase
	flavoprotein-linked monooxygenase
	cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 2
	Cyp1a1
	P450-3
	cytochrome P450-P2
	aromatic compound inducible
	cytochrome P450, 1a2, aromatic compound inducible
	cytochrome P450 family 1 subfamily a polypeptide 1
	CYPD45
	P-450d
	RATCYPD45
	P-448
	P450-D
	cytochrome P-448
	cytochrome P-450d
	cytochrome P450-D
	cytochrome P450, 1a2
	Cytochrome P450 subfamily I (aromatic compound-inducible) member A2 (Q42 form d)
	cytochrome P450, subfamily I (aromatic compound-inducible), member A2 (Q42, form d)
	Cyp1a-2
	CYP1A2
	cytochrome P450 1A2 aromatic compound inducible
	cytochrome P450 I (aromatic compound-inducible) 2
	cytochrome P450 I (aromatic compound-inducible) A2
	cytochrome P450 I (aromatic compound-inducible) II
	P450 (CYP) 1A2
	P450 (CYP) 4
	P450 (CYP) IV
	P450 1A2
	P450 4
	P450 IV
	P4501A2
	P-450ds
	P450-P3
	phenacetin O-deethylase

OMIM ID	124060

Mouse chromosome position	9 31.0 cM

Rat chromosome position	8q24

EC Number	1.14.14.1

Cell Localization	Endoplasmic reticulum membrane
	Microsome membrane
	Cytoplasm

Homologene ID	68082

RGD ID	735711

MGI ID	88589