| URN | urn:agi-llid:9915 |
|---|---|
| Connectivity | 20 |
| Name | Arnt2 |
| Description | aryl-hydrocarbon receptor nuclear translocator 2 |
| Notes | This gene encodes a member of the basic-helix-loop-helix-Per-Arnt-Sim (bHLH-PAS) superfamily of transcription factors. The encoded protein acts as a partner for several sensor proteins of the bHLH-PAS family, forming heterodimers with the sensor proteins that bind regulatory DNA sequences in genes responsive to developmental and environmental stimuli. Under hypoxic conditions, the encoded protein complexes with hypoxia-inducible factor 1alpha in the nucleus and this complex binds to hypoxia-responsive elements in enhancers and promoters of oxygen-responsive genes. A highly similar protein in mouse forms functional complexes with both aryl hydrocarbon receptors and Single-minded proteins, suggesting addition roles for the encoded protein in the metabolism of xenobiotic compounds and the regulation of neurogenesis, respectively. [provided by RefSeq] |
| Pathway | hypoxia inducible factor pathway |
|---|---|
| altered hypoxia inducible factor pathway |
| GO Molecular Function | transcription regulator activity |
|---|---|
| signal transducer activity | |
| transcription factor activity | |
| DNA binding | |
| aryl hydrocarbon receptor binding | |
| protein heterodimerization activity |
| GO Cellular Component | transcription factor complex |
|---|---|
| nucleus |
| GO Biological Process | positive regulation of cell proliferation |
|---|---|
| response to chemical stimulus | |
| central nervous system development | |
| in utero embryonic development | |
| signal transduction | |
| regulation of transcription | |
| positive regulation of transcription | |
| positive regulation of transcription from RNA polymerase II promoter | |
| regulation of transcription, DNA-dependent | |
| negative regulation of apoptosis | |
| transcription | |
| response to xenobiotic stimulus | |
| response to toxin | |
| response to hypoxia | |
| response to estradiol stimulus |
| Ariadne Ontology | PAS domain |
|---|
| Group | PAS domain |
|---|---|
| transcription regulator activity | |
| positive regulation of cell proliferation | |
| response to chemical stimulus | |
| central nervous system development | |
| in utero embryonic development | |
| signal transduction | |
| regulation of transcription | |
| positive regulation of transcription | |
| positive regulation of transcription from RNA polymerase II promoter | |
| regulation of transcription, DNA-dependent | |
| negative regulation of apoptosis | |
| transcription | |
| response to xenobiotic stimulus | |
| response to toxin | |
| response to hypoxia | |
| response to estradiol stimulus | |
| signal transducer activity | |
| transcription factor activity | |
| DNA binding | |
| aryl hydrocarbon receptor binding | |
| protein heterodimerization activity | |
| transcription factor complex | |
| nucleus |
| MedScan ID | 9915 |
|---|
| Hugo ID | 16876 |
|---|
| Human chromosome position | 15q24 |
|---|
| LocusLink ID | 9915 |
|---|---|
| 11864 | |
| 25243 |
| Alias | bHLHe1 |
|---|---|
| KIAA0307 | |
| aryl hydrocarbon receptor nuclear translocator 2 | |
| ARNT protein 2 | |
| class E basic helix-loop-helix protein 1 | |
| Hif-2b | |
| mKIAA0307 | |
| ARNT II | |
| ARNT IIs | |
| ARNT2 | |
| aryl-hydrocarbon receptor nuclear translocator II |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 606036 |
|---|
| Mouse chromosome position | 7 42.5 cM |
|---|
| GO ID | 0017162 |
|---|---|
| 0046982 | |
| 0004871 | |
| 0003700 | |
| 0030528 | |
| 0007417 | |
| 0001701 | |
| 0043066 | |
| 0008284 | |
| 0045941 | |
| 0045944 | |
| 0045449 | |
| 0006355 | |
| 0032355 | |
| 0001666 | |
| 0005634 | |
| 0005667 | |
| 0003677 | |
| 0009636 | |
| 0009410 | |
| 0007165 | |
| 0006350 | |
| 0042221 |
| Rat chromosome position | 1q31 |
|---|
| Swiss-Prot Accession | Q7Z3A3 |
|---|---|
| Q86TN1 | |
| Q9HBZ2 | |
| Q61324 | |
| Q78E60 | |
| Q7TQG2 | |
| Q8CHG9 | |
| Q30B64 | |
| Q63643 | |
| Q63646 | |
| Q80T24 | |
| B4DIS7 | |
| O15024 | |
| Q8IYC2 |
| Unigene ID | Hs.459070 |
|---|---|
| Mm.38594 | |
| Rn.10518 |
| KEGG ID | hsa:9915 |
|---|---|
| mmu:11864 | |
| rno:25243 |
| Swiss-Prot ID | ARNT2_MOUSE |
|---|---|
| ARNT2_RAT | |
| ARNT2_HUMAN | |
| Q7Z3A3_HUMAN | |
| Q86TN1_HUMAN |
| Cell Localization | Nucleus |
|---|
| IPI ID | IPI00403978 |
|---|---|
| IPI00828407 | |
| IPI00211044 | |
| IPI00829430 | |
| IPI00465064 | |
| IPI00478506 | |
| IPI00796054 |
| Homologene ID | 7230 |
|---|
| RGD ID | 2154 |
|---|
| MGI ID | 107188 |
|---|