Protein Arnt

URN	urn:agi-llid:405
Connectivity	221
Name	Arnt
Description	aryl hydrocarbon receptor nuclear translocator
Notes	The aryl hydrocarbon (Ah) receptor is involved in the induction of several enzymes that participate in xenobiotic metabolism. The ligand-free, cytosolic form of the Ah receptor is complexed to heat shock protein 90. Binding of ligand, which includes dioxin and polycyclic aromatic hydrocarbons, results in translocation of the ligand-binding subunit only to the nucleus. Induction of enzymes involved in xenobiotic metabolism occurs through binding of the ligand-bound Ah receptor to xenobiotic responsive elements in the promoters of genes for these enzymes. This gene encodes a protein that forms a complex with the ligand-bound Ah receptor, and is required for receptor function. The encoded protein has also been identified as the beta subunit of a heterodimeric transcription factor, hypoxia-inducible factor 1 (HIF1). A t(1;12)(q21;p13) translocation, which results in a TEL-ARNT fusion protein, is associated with acute myeloblastic leukemia. Three alternatively spliced variants encoding different isoforms have been described for this gene. [provided by RefSeq]

Pathway	hypoxia inducible factor pathway
	altered hypoxia inducible factor pathway

GO Molecular Function	transcription regulator activity
	signal transducer activity
	transcription activator activity
	transcription factor activity
	transcription factor binding
	DNA binding
	aryl hydrocarbon receptor binding
	protein heterodimerization activity
	transcription coactivator activity
	sequence-specific DNA binding
	RNA polymerase II transcription factor activity, enhancer binding
	receptor activity

GO Cellular Component	cytoplasm
	transcription factor complex
	nucleus

GO Biological Process	cell differentiation
	embryonic placenta development
	positive regulation of erythrocyte differentiation
	positive regulation vascular endothelial growth factor production
	signal transduction
	positive regulation of vascular endothelial growth factor receptor signaling pathway
	regulation of transcription
	positive regulation of glycolysis
	positive regulation of transcription
	positive regulation of hormone biosynthetic process
	positive regulation of gene-specific transcription
	positive regulation of transcription from RNA polymerase II promoter
	positive regulation of protein sumoylation
	regulation of transcription, DNA-dependent
	regulation of transcription from RNA polymerase II promoter in response to oxidative stress
	positive regulation of endothelial cell proliferation
	transcription
	transcription, DNA-dependent
	mRNA transcription from RNA polymerase II promoter
	response to toxin
	response to hypoxia

Ariadne Ontology	PAS domain

Group	PAS domain
	transcription regulator activity
	cell differentiation
	embryonic placenta development
	positive regulation of erythrocyte differentiation
	positive regulation vascular endothelial growth factor production
	signal transduction
	positive regulation of vascular endothelial growth factor receptor signaling pathway
	regulation of transcription
	positive regulation of glycolysis
	positive regulation of transcription
	positive regulation of hormone biosynthetic process
	positive regulation of gene-specific transcription
	positive regulation of transcription from RNA polymerase II promoter
	positive regulation of protein sumoylation
	regulation of transcription, DNA-dependent
	regulation of transcription from RNA polymerase II promoter in response to oxidative stress
	positive regulation of endothelial cell proliferation
	transcription
	transcription, DNA-dependent
	mRNA transcription from RNA polymerase II promoter
	response to toxin
	response to hypoxia
	signal transducer activity
	transcription activator activity
	transcription factor activity
	transcription factor binding
	DNA binding
	aryl hydrocarbon receptor binding
	protein heterodimerization activity
	transcription coactivator activity
	sequence-specific DNA binding
	RNA polymerase II transcription factor activity, enhancer binding
	receptor activity
	cytoplasm
	transcription factor complex
	nucleus

MedScan ID	405

Hugo ID	700

Human chromosome position	1q21

Alias	HIF1B
	TANGO
	bHLHe2
	HIF1BETA
	HIF-1beta
	aryl hydrocarbon receptor nuclear translocator
	HIF1-beta
	HIF-1-beta
	OTTHUMP00000218220
	hypoxia-inducible factor 1-beta
	dioxin receptor, nuclear translocator
	class E basic helix-loop-helix protein 2
	hypoxia-inducible factor 1, beta subunit
	Drnt
	ESTM42
	W08714
	KIAA4051
	mKIAA4051
	D3Ertd557e
	OTTMUSP00000017720
	OTTMUSP00000017721
	Arnt1
	HIF-1 beta
	hypoxia-inducible factor 1 beta
	Aryl hydrocarbon receptor nuclear translocator 1
	AhR nuclear translocator
	ARNT
	Arnt I
	aryl hydrocarbon receptor (AhR) nuclear translocator
	Aryl hydrocarbon receptor nuclear translocator I
	DNA segment, Chr 3, ERATO Doi 557, expressed
	EST W08714
	FLJ43542
	nuclear Dioxin receptor translocator
	nuclear translocator
	OTTHUMP00000032943
	tag mouse EST 42

OMIM ID	126110

Mouse chromosome position	3 47.9 cM

Rat chromosome position	2q34

Cell Localization	Nucleus

Homologene ID	1261

RGD ID	2153

MGI ID	88071