Ariadne Genomics Inc. Hif1a-O2 altered citric acid cycle pathway --+> fumarate altered citric acid cycle pathway --+> succinate Crebbp fumarate ---| Egln1 Egln1 succinate ---| Egln1 EP300 Egln2 Egln3 Tceb1 recruited complex Arnt Egln1 ---- Os9 Os9 Hif1an Sat2 Tceb1 Sat1 Gnb2l1 Gnb2l1 ---- Sat1 Gnb2l1 ---- Tceb1 Tceb1 ---- Tceb1 recruited complex Epas1 Hif3a Arnt2 Hif1a-O2 ---> Hif target genes Vhl Hif target genes altered citric acid cycle pathway fumarate succinate