| URN | urn:agi-llid:9785 |
|---|---|
| Total Entities | 0 |
| Connectivity | 38 |
| Name | Dhx38 |
| Description | DEAH (Asp-Glu-Ala-His) box polypeptide 38 |
| Notes | DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a member of the DEAD/H box family of splicing factors. This protein resembles yeast Prp16 more closely than other DEAD/H family members. It is an ATPase and essential for the catalytic step II in pre-mRNA splicing process. [provided by RefSeq, Jul 2008] |
| GO Molecular Function | ATP-dependent helicase activity |
|---|---|
| hydrolase activity | |
| helicase activity | |
| nucleotide binding | |
| ATP binding | |
| nucleic acid binding |
| GO Cellular Component | nucleoplasm |
|---|---|
| catalytic step 2 spliceosome | |
| nucleus |
| GO Biological Process | transcription from RNA polymerase II promoter |
|---|---|
| termination of RNA polymerase II transcription | |
| RNA splicing | |
| mRNA splicing, via spliceosome | |
| mRNA 3'-end processing | |
| gene expression | |
| mRNA export from nucleus |
| Pathway | spliceosomal pathway |
|---|---|
| spliceosome pathway |
| Group | mRNA processing |
|---|---|
| ATP-dependent helicase activity | |
| hydrolase activity | |
| helicase activity | |
| transcription from RNA polymerase II promoter | |
| termination of RNA polymerase II transcription | |
| RNA splicing | |
| mRNA splicing, via spliceosome | |
| mRNA 3'-end processing | |
| gene expression | |
| mRNA export from nucleus | |
| nucleotide binding | |
| ATP binding | |
| nucleic acid binding | |
| nucleoplasm | |
| catalytic step 2 spliceosome | |
| nucleus |
| LocusLink ID | 9785 |
|---|---|
| 64340 | |
| 292007 |
| Cell Localization | Nucleus |
|---|
| GO ID | 0005524 |
|---|---|
| 0008026 | |
| 0003676 | |
| 0008380 | |
| 0010467 | |
| 0031124 | |
| 0006406 | |
| 0000398 | |
| 0006369 | |
| 0006366 | |
| 0071013 | |
| 0005654 | |
| 0005634 | |
| 0004386 | |
| 0016787 | |
| 0000166 |
| Alias | DDX38 |
|---|---|
| PRP16 | |
| PRPF16 | |
| pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 | |
| DEAH box protein 38 | |
| PRP16 homolog of S.cerevisiae | |
| ATP-dependent RNA helicase DHX38 | |
| DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 38 | |
| pre-mRNA splicing factor ATP-dependent RNA helicase PRP16 | |
| AI325984 | |
| AW540902 | |
| mKIAA0224 | |
| 5730550P09Rik | |
| pre-mRNA splicing factor 16 | |
| RIKEN cDNA 5730550P09 gene | |
| U89410 | |
| hPrp16 | |
| pre-mRNA splicing factor Prp16 | |
| LOC292007 | |
| KIAA0224 | |
| 5730550P09 | |
| homolog of yeast PRP16 | |
| DEAH (Asp-Glu-Ala-His) box polypeptide 38 | |
| DHX38 |
| Mouse chromosome position | 8 |
|---|
| OMIM ID | 605584 |
|---|
| Rat chromosome position | 19q12 |
|---|
| Hugo ID | 17211 |
|---|
| Human chromosome position | 16q22 |
|---|
| Swiss-Prot Accession | Q92620 |
|---|---|
| Q80X98 | |
| D4A321 | |
| D3DWS7 | |
| O75212 | |
| Q96HN7 |
| Unigene ID | Hs.151218 |
|---|---|
| Mm.23705 | |
| Rn.35093 |
| KEGG ID | hsa:9785 |
|---|---|
| mmu:64340 | |
| rno:292007 |
| Swiss-Prot ID | PRP16_HUMAN |
|---|
| EC Number | 3.6.4.13 |
|---|
| Ensembl ID | ENSG00000140829 |
|---|---|
| ENSP00000268482 | |
| ENST00000268482 | |
| ENSMUSG00000037993 | |
| ENSMUSP00000047865 | |
| ENSMUST00000042601 | |
| ENSRNOG00000014619 | |
| ENSRNOP00000019810 | |
| ENSRNOT00000019810 |
| Homologene ID | 8512 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 1927617 |
|---|
| RGD ID | 1310345 |
|---|
| MedScan ID | 9785 |
|---|