Protein Ddx39b

URN	urn:agi-llid:7919
Total Entities	0
Connectivity	114
Name	Ddx39b
Description	DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B
Notes	This gene encodes a member of the DEAD box family of RNA-dependent ATPases that mediate ATP hydrolysis during pre-mRNA splicing. The encoded protein is an essential splicing factor required for association of U2 small nuclear ribonucleoprotein with pre-mRNA, and it also plays an important role in mRNA export from the nucleus to the cytoplasm. This gene belongs to a cluster of genes localized in the vicinity of the genes encoding tumor necrosis factor alpha and tumor necrosis factor beta. These genes are all within the human major histocompatibility complex class III region. Mutations in this gene may be associated with rheumatoid arthritis. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on both chromosomes 6 and 11. Read-through transcription also occurs between this gene and the upstream ATP6V1G2 (ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2) gene. [provided by RefSeq, Feb 2011]

GO Molecular Function	ATP-dependent helicase activity
	RNA-dependent ATPase activity
	ATP-dependent RNA helicase activity
	hydrolase activity
	helicase activity
	ATP-dependent protein binding
	nucleotide binding
	ATP binding
	nucleic acid binding
	RNA binding
	U4 snRNA binding
	U6 snRNA binding

GO Cellular Component	spliceosomal complex
	transcription export complex
	nuclear speck
	U4 snRNP
	U6 snRNP
	cytoplasm
	nucleus

GO Biological Process	ATP catabolic process
	negative regulation of DNA damage checkpoint
	positive regulation of DNA-templated transcription, elongation
	RNA secondary structure unwinding
	RNA splicing
	mRNA processing
	mRNA splicing, via spliceosome
	spliceosomal complex assembly
	mRNA export from nucleus
	viral mRNA export from host cell nucleus
	transport
	mRNA transport

Pathway	mRNA Transcription and Processing
	spliceosomal pathway
	spliceosome pathway

Group	mRNA processing
	Nuclear export
	ATP catabolic process
	ATP-dependent helicase activity
	RNA-dependent ATPase activity
	ATP-dependent RNA helicase activity
	negative regulation of DNA damage checkpoint
	positive regulation of DNA-templated transcription, elongation
	hydrolase activity
	helicase activity
	RNA secondary structure unwinding
	RNA splicing
	mRNA processing
	mRNA splicing, via spliceosome
	spliceosomal complex assembly
	mRNA export from nucleus
	viral mRNA export from host cell nucleus
	transport
	mRNA transport
	ATP-dependent protein binding
	nucleotide binding
	ATP binding
	nucleic acid binding
	RNA binding
	U4 snRNA binding
	U6 snRNA binding
	spliceosomal complex
	transcription export complex
	nuclear speck
	U4 snRNP
	U6 snRNP
	cytoplasm
	nucleus

Alias	BAT1
	UAP56
	D6S81E
	DAAP-97M17.4
	spliceosome RNA helicase DDX39B
	spliceosome RNA helicase BAT1
	ATP-dependent RNA helicase p47
	56 kDa U2AF65-associated protein
	nuclear RNA helicase (DEAD family)
	HLA-B-associated transcript 1 protein
	Bat-1
	Bat1a
	D6S81Eh
	AI428441
	D17H6S81E
	D17H6S81E-1
	0610030D10Rik
	DEAD box protein UAP56
	nuclear RNA helicase Bat1
	HLA-B-associated transcript 1A
	p47
	D20H6S81e
	Nuclear RNA helicase
	HLA-B associated transcript 1
	HLA-B associated transcript 1A
	MGC19235
	OTTHUMP00000029231
	OTTHUMP00000029229
	OTTHUMP00000029228
	Nuclear RNA helicase 61
	MGC38799
	OTTHUMP00000035591
	OTTHUMP00000035963
	OTTHUMP00000035965
	OTTHUMP00000035968
	OTTHUMP00000165889
	LOC56472
	Probable ATP-dependent RNA helicase p47
	OTTHUMP00000035964
	RIKEN cDNA 0610030D10 gene
	OTTHUMP00000165890
	D17H6S81E I
	OTTHUMP00000035966
	BAT I
	HLA-B associated transcript I
	0610030D10
	DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B
	DEAD-box protein 61
	DDX39B
	DEAD-box protein UAP56

Mouse chromosome position	17 18.6 cM

OMIM ID	142560

Rat chromosome position	20p12

Hugo ID	13917

Human chromosome position	6p21.3

PIR ID	A42811
	I37201

EC Number	3.6.4.13

Homologene ID	48376

MGI ID	99240

RGD ID	70923

MedScan ID	7919