| URN | urn:agi-llid:8449 |
|---|---|
| Total Entities | 0 |
| Connectivity | 55 |
| Name | Dhx16 |
| Description | DEAH (Asp-Glu-Ala-His) box polypeptide 16 |
| Notes | DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is a functional homolog of fission yeast Prp8 protein involved in cell cycle progression. This gene is mapped to the MHC region on chromosome 6p21.3, a region where many malignant, genetic and autoimmune disease genes are linked. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009] |
| GO Molecular Function | ATP-dependent helicase activity |
|---|---|
| hydrolase activity | |
| helicase activity | |
| RNA helicase activity | |
| nucleotide binding | |
| ATP binding | |
| nucleic acid binding |
| GO Cellular Component | nucleolus |
|---|---|
| nucleus |
| GO Biological Process | RNA splicing |
|---|---|
| mRNA processing |
| Pathway | spliceosomal pathway |
|---|---|
| spliceosome pathway |
| Group | mRNA processing |
|---|---|
| ATP-dependent helicase activity | |
| hydrolase activity | |
| helicase activity | |
| RNA helicase activity | |
| RNA splicing | |
| mRNA processing | |
| nucleotide binding | |
| ATP binding | |
| nucleic acid binding | |
| nucleolus | |
| nucleus |
| LocusLink ID | 8449 |
|---|---|
| 69192 | |
| 294232 |
| Cell Localization | Nucleus |
|---|
| GO ID | 0005524 |
|---|---|
| 0008026 | |
| 0003724 | |
| 0003676 | |
| 0008380 | |
| 0006397 | |
| 0005730 | |
| 0005634 | |
| 0004386 | |
| 0016787 | |
| 0000166 |
| Alias | DBP2 |
|---|---|
| PRP8 | |
| Prp2 | |
| DDX16 | |
| PRPF2 | |
| PRO2014 | |
| DADB-129D20.3 | |
| putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 | |
| RNA helicase | |
| DEAD/H box 16 | |
| DEAH-box protein 16 | |
| ATP-dependent RNA helicase #3 | |
| DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 16 | |
| mKIAA0577 | |
| 2410006N22Rik | |
| DEAH (Asp-Glu-Ala-His) box polypeptide 16 | |
| KIAA0577 | |
| DEAD-box protein 16 | |
| OTTHUMP00000029071 | |
| LOC257593 | |
| LOC257542 | |
| LOC112961 | |
| DHX16 | |
| ATP-dependent RNA helicase 3 | |
| 2410006N22 | |
| dead\/h (asp-glu-ala-asp\/his) box polypeptide 16 |
| Mouse chromosome position | 17 |
|---|
| OMIM ID | 603405 |
|---|
| Rat chromosome position | 20p12 |
|---|
| Hugo ID | 2739 |
|---|
| Human chromosome position | 6p21.3 |
|---|
| Swiss-Prot Accession | B4DZ28 |
|---|---|
| O60231 | |
| Q5SQH4 | |
| G3X8X0 | |
| Q921Y1 | |
| Q9CRI3 | |
| Q6MG13 | |
| O60322 | |
| Q5JP45 | |
| Q969X7 | |
| Q96QC1 |
| Unigene ID | Hs.485060 |
|---|---|
| Mm.390986 | |
| Rn.6832 |
| KEGG ID | hsa:8449 |
|---|---|
| mmu:69192 | |
| rno:294232 |
| Swiss-Prot ID | DHX16_HUMAN |
|---|
| EC Number | 3.6.4.13 |
|---|
| Ensembl ID | ENSG00000204560 |
|---|---|
| ENSP00000365625 | |
| ENST00000376442 | |
| ENSMUSG00000024422 | |
| ENSMUSP00000025292 | |
| ENSMUST00000025292 | |
| ENSRNOG00000030157 | |
| ENSRNOP00000062603 | |
| ENSRNOT00000065025 |
| Homologene ID | 2658 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 1916442 |
|---|
| RGD ID | 1302963 |
|---|
| MedScan ID | 8449 |
|---|