| URN | urn:agi-llid:11338 |
|---|---|
| Total Entities | 0 |
| Connectivity | 165 |
| Name | U2af2 |
| Description | U2 small nuclear RNA auxiliary factor 2 |
| Notes | U2 auxiliary factor (U2AF), comprised of a large and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. This gene encodes the U2AF large subunit which contains a sequence-specific RNA-binding region with 3 RNA recognition motifs and an Arg/Ser-rich domain necessary for splicing. The large subunit binds to the polypyrimidine tract of introns early during spliceosome assembly. Multiple transcript variants have been detected for this gene, but the full-length natures of only two have been determined to date. [provided by RefSeq, Jul 2008] |
| GO Molecular Function | enzyme binding |
|---|---|
| C2H2 zinc finger domain binding | |
| nucleotide binding | |
| nucleic acid binding | |
| RNA binding |
| GO Cellular Component | virion |
|---|---|
| spliceosomal complex | |
| nucleoplasm | |
| nuclear speck | |
| ribonucleoprotein complex | |
| nucleus | |
| viral nucleocapsid |
| GO Biological Process | negative regulation of mRNA splicing, via spliceosome |
|---|---|
| transcription from RNA polymerase II promoter | |
| termination of RNA polymerase II transcription | |
| RNA splicing | |
| mRNA processing | |
| mRNA splicing, via spliceosome | |
| mRNA 3'-end processing | |
| gene expression | |
| mRNA export from nucleus |
| Pathway | mRNA Transcription and Processing |
|---|---|
| spliceosomal pathway | |
| spliceosome pathway |
| Group | mRNA processing |
|---|---|
| negative regulation of mRNA splicing, via spliceosome | |
| transcription from RNA polymerase II promoter | |
| termination of RNA polymerase II transcription | |
| RNA splicing | |
| mRNA processing | |
| mRNA splicing, via spliceosome | |
| mRNA 3'-end processing | |
| gene expression | |
| mRNA export from nucleus | |
| enzyme binding | |
| C2H2 zinc finger domain binding | |
| nucleotide binding | |
| nucleic acid binding | |
| RNA binding | |
| virion | |
| spliceosomal complex | |
| nucleoplasm | |
| nuclear speck | |
| ribonucleoprotein complex | |
| nucleus | |
| viral nucleocapsid |
| LocusLink ID | 11338 |
|---|---|
| 22185 | |
| 308335 |
| Cell Localization | Nucleus |
|---|
| GO ID | 0070742 |
|---|---|
| 0003723 | |
| 0019899 | |
| 0000166 | |
| 0008380 | |
| 0010467 | |
| 0031124 | |
| 0006406 | |
| 0006397 | |
| 0000398 | |
| 0048025 | |
| 0006369 | |
| 0006366 | |
| 0005654 | |
| 0005681 | |
| 0003676 | |
| 0016607 | |
| 0005634 | |
| 0030529 | |
| 0019013 | |
| 0019012 |
| Alias | U2AF65 |
|---|---|
| splicing factor U2AF 65 kDa subunit | |
| hU2AF65 | |
| U2 auxiliary factor 65 kDa subunit | |
| U2 snRNP auxiliary factor large subunit | |
| U2 (RNU2) small nuclear RNA auxiliary factor 2 | |
| U2 small nuclear ribonucleoprotein auxiliary factor (65kD) | |
| 65kDa | |
| U2 small nuclear ribonucleoprotein auxiliary factor (U2AF), 65 kDa | |
| U2 small nuclear RNA auxiliary factor 2 | |
| U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 2 | |
| U2AF65-P | |
| u2 small nuclear ribonucleoprotein auxiliary factor (u2af) II | |
| U2AF | |
| MGC118033 | |
| u2 small nuclear ribonucleoprotein auxiliary factor | |
| U2af2 | |
| splicing factor U2AF | |
| hU2AF(65) | |
| U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) | |
| LOC690372 | |
| splicing factor u2af 65 kd subunit | |
| u2 (rnu2) small nuclear rna auxiliary factor II | |
| U2 small nuclear ribonuclear protein auxiliary factor (U2AF) |
| Mouse chromosome position | 7 |
|---|
| OMIM ID | 191318 |
|---|
| Rat chromosome position | 1q12 |
|---|
| Hugo ID | 23156 |
|---|
| Human chromosome position | 19q13.42 |
|---|
| Swiss-Prot Accession | P26368 |
|---|---|
| P26369 | |
| Q80XR5 | |
| F2Z3T9 | |
| Q96HC5 |
| PIR ID | S22646 |
|---|---|
| S20250 |
| Unigene ID | Hs.528007 |
|---|---|
| Mm.360389 | |
| Rn.15383 |
| KEGG ID | hsa:11338 |
|---|---|
| mmu:22185 | |
| rno:308335 |
| Swiss-Prot ID | U2AF2_MOUSE |
|---|---|
| U2AF2_HUMAN |
| Ensembl ID | ENSG00000063244 |
|---|---|
| ENSP00000388475 | |
| ENST00000450554 | |
| ENSMUSG00000030435 | |
| ENSMUSP00000005041 | |
| ENSMUST00000005041 | |
| ENSRNOG00000015914 | |
| ENSRNOP00000021392 | |
| ENSRNOT00000021391 |
| Homologene ID | 110853 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 98886 |
|---|
| RGD ID | 1310690 |
|---|
| MedScan ID | 11338 |
|---|