Protein U2af1

URN	urn:agi-llid:7307
Total Entities	0
Connectivity	94
Name	U2af1
Description	U2 small nuclear RNA auxiliary factor 1
Notes	This gene belongs to the splicing factor SR family of genes. U2 auxiliary factor, comprising a large and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. This gene encodes the small subunit which plays a critical role in both constitutive and enhancer-dependent RNA splicing by directly mediating interactions between the large subunit and proteins bound to the enhancers. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

GO Biological Process	transcription from RNA polymerase II promoter
	termination of RNA polymerase II transcription
	RNA splicing
	mRNA processing
	mRNA splicing, via spliceosome
	mRNA 3'-end processing
	gene expression
	mRNA export from nucleus

Pathway	mRNA Transcription and Processing
	spliceosomal pathway
	spliceosome pathway

Group	mRNA processing
	transcription from RNA polymerase II promoter
	termination of RNA polymerase II transcription
	RNA splicing
	mRNA processing
	mRNA splicing, via spliceosome
	mRNA 3'-end processing
	gene expression
	mRNA export from nucleus
	RS domain binding
	nucleotide binding
	nucleic acid binding
	RNA binding
	metal ion binding
	virion
	spliceosomal complex
	nucleoplasm
	nucleolus
	Cajal body
	nuclear speck
	catalytic step 2 spliceosome
	ribonucleoprotein complex
	nucleus
	viral nucleocapsid

LocusLink ID	7307
	108121

Cell Localization	Nucleus
	Nucleus speckle

Alias	RN
	FP793
	U2AF35
	U2AFBP
	RNU2AF1
	splicing factor U2AF 35 kDa subunit
	splicing factor U2AF 35kDa subunit
	U2 small nuclear RNA auxillary factor 1
	U2 snRNP auxiliary factor small subunit
	U2(RNU2) small nuclear RNA auxiliary factor binding protein
	U2 small nuclear ribonucleoprotein auxillary factor, 35-KD subunit
	35kDa
	2010107D16Rik
	U2 auxiliary factor 35 kDa subunit
	U2 small nuclear ribonucleoprotein auxiliary factor (U2AF),35 kDa
	U2(RNU2) small nuclear RNA auxillary factor I
	U2(RNU2) small nuclear RNA auxillary factor 1
	U2(RNU2) small nuclear RNA auxiliary factor 1
	U2(RNU2) small nuclear RNA auxillary factor binding protein
	U2(RNU2) small nuclear RNA auxillary factor binding protein (non-standard symbol)
	U2af I
	U2af1
	U2AG
	U2AG_HUMAN
	RIKEN cDNA 2010107D16 gene
	U2af26
	DKFZp313J1712
	U2 small nuclear RNA auxiliary factor 1
	U2 snRNP auxiliary factor small chain
	OTTHUMP00000214620
	RNU2AF I
	U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 1
	U2 small nuclear RNA auxillary factor I
	2010107D16

Mouse chromosome position	17

OMIM ID	191317

Hugo ID	12453

Human chromosome position	21q22.3

PIR ID	A46179

Unigene ID	Hs.365116
	Mm.379289

KEGG ID	hsa:7307
	mmu:108121

Swiss-Prot ID	U2AF1_HUMAN
	U2AF1_MOUSE

Homologene ID	14345

Organism	Homo sapiens
	Mus musculus

MGI ID	98884

RGD ID	1584190

MedScan ID	7307