Protein Dhx8

URN	urn:agi-llid:1659
Total Entities	0
Connectivity	32
Name	Dhx8
Description	DEAH (Asp-Glu-Ala-His) box polypeptide 8
Notes	DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is highly homologous to yeast Prp22. This protein facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome. [provided by RefSeq, Jul 2008]

GO Molecular Function	ATP-dependent helicase activity
	ATP-dependent RNA helicase activity
	hydrolase activity
	helicase activity
	nucleotide binding
	ATP binding
	nucleic acid binding
	RNA binding

GO Biological Process	RNA processing
	RNA splicing
	mRNA processing
	mRNA splicing, via spliceosome

Pathway	spliceosomal pathway
	spliceosome pathway

Group	mRNA processing
	ATP-dependent helicase activity
	ATP-dependent RNA helicase activity
	hydrolase activity
	helicase activity
	RNA processing
	RNA splicing
	mRNA processing
	mRNA splicing, via spliceosome
	nucleotide binding
	ATP binding
	nucleic acid binding
	RNA binding
	spliceosomal complex
	nucleolus
	catalytic step 2 spliceosome
	nucleus

Cell Localization	Nucleus

Alias	DDX8
	HRH1
	PRP22
	PRPF22
	ATP-dependent RNA helicase DHX8
	RNA helicase HRH1
	DEAH box protein 8
	DEAH-box protein 8
	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 8 (RNA helicase)
	mDEAH6
	mKIAA4096
	RP23-434F13.5
	RNA helicase
	DEAD (aspartate-glutamate-alanine-aspartate) box polypeptide 8
	LRRGT00035
	HRH I
	KIAA4096
	OTTMUSP00000002847
	RNA helicase HRH I
	DHX8
	MGC31290
	D-E-A-D (aspartate-glutamate-alanine-aspartate) box polypeptide 8
	DEAH-box protein VIII
	ATP-dependent helicase DDX8
	OTTMUSP00000002846
	DEAD (aspartate-glutamate-alanine-aspartate) box polypeptide VIII
	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 8
	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide VIII
	DEAH (Asp-Glu-Ala-His) box polypeptide 8
	DEAH (Asp-Glu-Ala-His) box polypeptide VIII

Mouse chromosome position	11

OMIM ID	600396

Rat chromosome position	10q32.1

Hugo ID	2749

Human chromosome position	17q21.31

PIR ID	A56236

Swiss-Prot ID	DHX8_HUMAN
	DHX8_MOUSE

EC Number	3.6.4.13
	3.6.1.-

Homologene ID	3628

MGI ID	1306823

RGD ID	1310723

MedScan ID	1659