| URN | urn:agi-llid:9879 |
|---|---|
| Total Entities | 0 |
| Connectivity | 30 |
| Name | Ddx46 |
| Description | DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 |
| Notes | This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a component of the 17S U2 snRNP complex; it plays an important role in pre-mRNA splicing. [provided by RefSeq, Jul 2008] |
| GO Molecular Function | ATP-dependent helicase activity |
|---|---|
| hydrolase activity | |
| helicase activity | |
| nucleotide binding | |
| ATP binding | |
| nucleic acid binding | |
| RNA binding |
| GO Cellular Component | nucleolus |
|---|---|
| Cajal body | |
| nuclear speck | |
| nucleus |
| GO Biological Process | RNA splicing |
|---|---|
| mRNA processing |
| Pathway | spliceosomal pathway |
|---|---|
| spliceosome pathway |
| Group | ATP-dependent helicase activity |
|---|---|
| hydrolase activity | |
| helicase activity | |
| RNA splicing | |
| mRNA processing | |
| nucleotide binding | |
| ATP binding | |
| nucleic acid binding | |
| RNA binding | |
| nucleolus | |
| Cajal body | |
| nuclear speck | |
| nucleus |
| LocusLink ID | 9879 |
|---|---|
| 212880 | |
| 245957 |
| Cell Localization | Nucleus speckle |
|---|---|
| Nucleus | |
| Cajal body |
| GO ID | 0005524 |
|---|---|
| 0008026 | |
| 0003723 | |
| 0008380 | |
| 0006397 | |
| 0015030 | |
| 0016607 | |
| 0005730 | |
| 0005634 | |
| 0004386 | |
| 0016787 | |
| 0003676 | |
| 0000166 |
| Alias | Prp5 |
|---|---|
| PRPF5 | |
| probable ATP-dependent RNA helicase DDX46 | |
| PRP5 homolog | |
| RNA helicase | |
| DEAD box protein 46 | |
| Prp5-like DEAD-box protein | |
| AI325430 | |
| AI957095 | |
| mKIAA0801 | |
| 2200005K02Rik | |
| 8430438J23Rik | |
| DEAD box polypeptide 46 | |
| helicase of 117.4 kDa | |
| Hel117 | |
| KIAA0801 | |
| MGC116676 | |
| MGC9936 | |
| RIKEN cDNA 8430438J23 gene | |
| LOC51139 | |
| MGC31579 | |
| RIKEN cDNA 2200005K02 gene | |
| DDX46 | |
| LOC245957 | |
| 8430438J23 | |
| DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 | |
| FLJ25329 | |
| 2200005K02 |
| Mouse chromosome position | 13 |
|---|
| Rat chromosome position | 17p14 |
|---|
| Hugo ID | 18681 |
|---|
| Human chromosome position | 5q31.1 |
|---|
| Swiss-Prot Accession | Q7L014 |
|---|---|
| Q569Z5 | |
| Q62780 | |
| O94894 | |
| Q96EI0 | |
| Q9Y658 | |
| Q6ZQ42 | |
| Q8R0R6 |
| PIR ID | A57514 |
|---|
| Unigene ID | Hs.406549 |
|---|---|
| Mm.202725 | |
| Rn.3436 |
| KEGG ID | hsa:9879 |
|---|---|
| mmu:212880 | |
| rno:245957 |
| Swiss-Prot ID | DDX46_RAT |
|---|---|
| DDX46_HUMAN | |
| DDX46_MOUSE |
| EC Number | 3.6.4.13 |
|---|
| Ensembl ID | ENSG00000145833 |
|---|---|
| ENSP00000416534 | |
| ENST00000452510 | |
| ENSP00000346236 | |
| ENST00000354283 | |
| ENSMUSG00000021500 | |
| ENSMUSP00000133245 | |
| ENSMUST00000172272 | |
| ENSRNOG00000021637 | |
| ENSRNOP00000030772 | |
| ENSRNOT00000029885 |
| Homologene ID | 5430 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 1920895 |
|---|
| RGD ID | 708480 |
|---|
| MedScan ID | 9879 |
|---|