| URN | urn:agi-llid:9416 |
|---|---|
| Total Entities | 0 |
| Connectivity | 25 |
| Name | Ddx23 |
| Description | DEAD (Asp-Glu-Ala-Asp) box polypeptide 23 |
| Notes | This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a component of the U5 snRNP complex; it may facilitate conformational changes in the spliceosome during nuclear pre-mRNA splicing. An alternatively spliced transcript variant has been found for this gene, but its biological validity has not been determined. [provided by RefSeq, Jul 2008] |
| GO Molecular Function | ATP-dependent helicase activity |
|---|---|
| ATP-dependent RNA helicase activity | |
| hydrolase activity | |
| helicase activity | |
| nucleotide binding | |
| ATP binding | |
| nucleic acid binding |
| GO Cellular Component | nucleoplasm |
|---|---|
| nucleolus | |
| catalytic step 2 spliceosome | |
| U4-U6 x U5 tri-snRNP complex | |
| U5 snRNP | |
| plasma membrane | |
| mitochondrion | |
| nucleus |
| GO Biological Process | RNA splicing |
|---|---|
| RNA splicing, via transesterification reactions | |
| mRNA splicing, via spliceosome | |
| cis assembly of pre-catalytic spliceosome | |
| gene expression |
| Pathway | spliceosomal pathway |
|---|---|
| spliceosome pathway |
| Group | Glucose metabolism |
|---|---|
| mRNA processing | |
| ATP-dependent helicase activity | |
| ATP-dependent RNA helicase activity | |
| hydrolase activity | |
| helicase activity | |
| RNA splicing | |
| RNA splicing, via transesterification reactions | |
| mRNA splicing, via spliceosome | |
| cis assembly of pre-catalytic spliceosome | |
| gene expression | |
| nucleotide binding | |
| ATP binding | |
| nucleic acid binding | |
| nucleoplasm | |
| nucleolus | |
| catalytic step 2 spliceosome | |
| U4-U6 x U5 tri-snRNP complex | |
| U5 snRNP | |
| plasma membrane | |
| mitochondrion | |
| nucleus |
| LocusLink ID | 9416 |
|---|---|
| 74351 | |
| 300208 |
| Cell Localization | Cytoplasm |
|---|---|
| Nucleus |
| GO ID | 0005524 |
|---|---|
| 0004004 | |
| 0008026 | |
| 0003676 | |
| 0008380 | |
| 0000375 | |
| 0000354 | |
| 0010467 | |
| 0000398 | |
| 0005682 | |
| 0071013 | |
| 0005739 | |
| 0005730 | |
| 0005654 | |
| 0005634 | |
| 0005886 | |
| 0004386 | |
| 0016787 | |
| 0000166 | |
| 0046540 |
| Alias | prp28 |
|---|---|
| PRPF28 | |
| U5-100K | |
| SNRNP100 | |
| U5-100KD | |
| probable ATP-dependent RNA helicase DDX23 | |
| PRP28p homolog | |
| DEAD box protein 23 | |
| PRP28 homolog, yeast | |
| U5 snRNP 100 kD protein | |
| 100 kDa U5 snRNP-specific protein | |
| 3110082M05Rik | |
| 4921506D17Rik | |
| RIKEN cDNA 3110082M05 gene | |
| prp28, U5 snRNP 100 kd protein | |
| 3110082M05 | |
| 4921506D17 | |
| DDX23 | |
| DEAD (Asp-Glu-Ala-Asp) box polypeptide 23 | |
| MGC8416 |
| Mouse chromosome position | 15 |
|---|
| OMIM ID | 612172 |
|---|
| Rat chromosome position | X |
|---|
| Hugo ID | 17347 |
|---|
| Human chromosome position | 12q13.12 |
|---|
| Swiss-Prot Accession | B3KY11 |
|---|---|
| Q9BUQ8 | |
| D3Z0M9 | |
| B5DFJ3 | |
| G3V9M1 | |
| B2R600 | |
| O43188 |
| Unigene ID | Hs.130098 |
|---|---|
| Mm.45725 | |
| Rn.2319 |
| KEGG ID | hsa:9416 |
|---|---|
| mmu:74351 | |
| rno:300208 |
| Swiss-Prot ID | DDX23_HUMAN |
|---|
| EC Number | 3.6.4.13 |
|---|---|
| 3.6.1.- |
| Ensembl ID | ENSG00000174243 |
|---|---|
| ENSP00000310723 | |
| ENST00000308025 | |
| ENSMUSG00000003360 | |
| ENSMUSP00000003450 | |
| ENSMUST00000003450 | |
| ENSRNOG00000036954 | |
| ENSRNOP00000052391 | |
| ENSRNOT00000055529 |
| Homologene ID | 3542 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 1921601 |
|---|
| RGD ID | 1308685 |
|---|
| MedScan ID | 9416 |
|---|