Elsevier Inc. hnRNP proteins ---- ISS ESS ---- hnRNP proteins microRNA pathway U6b* spliceosome disassembly excised lariat ISS ISE RNA polymerase II transcription pathway ---> intron intron RNA polymerase II transcription pathway exon1 PPIases, other regulators DHX15 ---> spliceosome disassembly DHX15 ESS ESE U6c U5c U5b* U6 U5 U2b spliced mRNA ESE ---- SR proteins spliced mRNA ---> mRNA nuclear export pathway EJC complex ---> mRNA nuclear export pathway mRNA nuclear export pathway EJC complex post-spliceosomal complex U2b* hnRNP proteins Prp19-associated proteins Prp19 complex U2 U1 U2c chromatin modification/remodeling pathway exon2 complex C complex B* first step reaction Dhx38 ---> second step reaction Dhx8 ---> second step reaction Dhx16 ---> first step reaction Dhx16 RNA polymerase II transcription pathway <--> chromatin modification/remodeling pathway Snrnp200 ---> complex B* Eftud2 ---> complex B* Eftud2 U2b* ---> complex B* Snrnp200 Ddx23 Ddx46 ---- U2 Ddx46 Ddx46 ---> complex A Ddx39b ---> complex A complex A complex E U2af1 ---> complex E Sf1 ---> complex E U2af2 U2af1 ---- U2af2 Sf1 ---- U2af2 U1 ---> complex E Sf1 U2af2 ---> complex E U2 ---> complex A U5b* ---> complex B* U5c ---> complex C U6c ---> complex C U2c ---> complex C complex B* ---> first step reaction complex C ---> second step reaction Ddx23 ---> complex B Ddx39b U1a U1b Prp19 complex ---> complex C Prp19-associated proteins ---> complex C Dhx38 Dhx8 Prpf18 ---> second step reaction Slu7 ---> second step reaction Prp19 complex ---> complex B* Prp19-associated proteins ---> complex B* U6b* ---> complex B* complex B Prpf18 Slu7 second step reaction ISE ---- SR proteins SR proteins U1a ---> complex A U1b ---> complex B U2b ---> complex B U4 ---> complex B U6 ---> complex B U5 ---> complex B U2af1 U4 PPIases, other regulators ---> spliced mRNA