| URN | urn:agi-llid:8021 |
|---|---|
| Total Entities | 0 |
| Connectivity | 145 |
| Name | Nup214 |
| Description | nucleoporin 214kDa |
| Notes | The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. This gene is a member of the FG-repeat-containing nucleoporins. The protein encoded by this gene is localized to the cytoplasmic face of the nuclear pore complex where it is required for proper cell cycle progression and nucleocytoplasmic transport. The 3' portion of this gene forms a fusion gene with the DEK gene on chromosome 6 in a t(6,9) translocation associated with acute myeloid leukemia and myelodysplastic syndrome. [provided by RefSeq, Jul 2008] |
| GO Molecular Function | transporter activity |
|---|---|
| nucleocytoplasmic transporter activity |
| GO Cellular Component | cell |
|---|---|
| nuclear pore | |
| nucleoplasm | |
| intracellular | |
| cytosol | |
| nucleus |
| GO Biological Process | small molecule metabolic process |
|---|---|
| transmembrane transport | |
| mitotic nuclear envelope disassembly | |
| regulation of cell cycle | |
| mitotic cell cycle | |
| cytokine-mediated signaling pathway | |
| protein export from nucleus | |
| protein import into nucleus | |
| hexose transport | |
| glucose transport | |
| regulation of glucose transport | |
| RNA metabolic process | |
| mRNA metabolic process | |
| carbohydrate metabolic process | |
| gene expression | |
| mRNA export from nucleus | |
| transport | |
| protein transport | |
| mRNA transport | |
| viral process |
| Pathway | Proteins Involved in Pathogenesis of T-cell Acute Lymphoblastic Leukemia |
|---|---|
| ribosome biogenesis pathway |
| Group | Nuclear pore organization and biogenesis |
|---|---|
| Protein nucleus import | |
| Nuclear export | |
| Oncogenes | |
| small molecule metabolic process | |
| transmembrane transport | |
| mitotic nuclear envelope disassembly | |
| regulation of cell cycle | |
| mitotic cell cycle | |
| cytokine-mediated signaling pathway | |
| protein export from nucleus | |
| protein import into nucleus | |
| hexose transport | |
| glucose transport | |
| regulation of glucose transport | |
| RNA metabolic process | |
| mRNA metabolic process | |
| carbohydrate metabolic process | |
| gene expression | |
| mRNA export from nucleus | |
| transport | |
| transporter activity | |
| nucleocytoplasmic transporter activity | |
| protein transport | |
| mRNA transport | |
| viral process | |
| cell | |
| nuclear pore | |
| nucleoplasm | |
| intracellular | |
| cytosol | |
| nucleus |
| LocusLink ID | 8021 |
|---|---|
| 227720 | |
| 296634 |
| Cell Localization | Nucleus |
|---|---|
| Nuclear pore complex |
| GO ID | 0005487 |
|---|---|
| 0005215 | |
| 0016070 | |
| 0005975 | |
| 0019221 | |
| 0010467 | |
| 0015758 | |
| 0008645 | |
| 0006406 | |
| 0016071 | |
| 0000278 | |
| 0007077 | |
| 0006611 | |
| 0006606 | |
| 0051726 | |
| 0010827 | |
| 0044281 | |
| 0055085 | |
| 0016032 | |
| 0005829 | |
| 0005643 | |
| 0005654 | |
| 0051028 | |
| 0015031 | |
| 0006810 | |
| 0005623 | |
| 0005622 | |
| 0005634 |
| Alias | CAN |
|---|---|
| CAIN | |
| N214 | |
| p250 | |
| D9S46E | |
| RP11-544A12.7 | |
| nuclear pore complex protein Nup214 | |
| CAN protein, putative oncogene | |
| BC039282 | |
| D2H9S46E | |
| RP23-55I14.4 | |
| nucleoporin Nup214 | |
| 214 kDa nucleoporin | |
| RGD1304977 | |
| nucleoporin 214 | |
| nucleoporin 214kDa | |
| KIAA0023 | |
| NUP214 | |
| nucleoporin 214kD | |
| nucleoporin 214kD (CAIN) | |
| OTTHUMP00000022384 | |
| OTTHUMP00000064563 | |
| OTTMUSP00000013944 | |
| MGC104525 | |
| CAN oncogene | |
| CAN protein | |
| cDNA sequence BC039282 | |
| LOC138630 | |
| MGC37347 |
| Mouse chromosome position | 2 21.97 cM |
|---|
| OMIM ID | 114350 |
|---|---|
| 601626 |
| Rat chromosome position | 3p11 |
|---|
| Hugo ID | 8064 |
|---|
| Human chromosome position | 9q34.1 |
|---|
| Swiss-Prot Accession | P35658 |
|---|---|
| Q80U93 | |
| A6NFQ0 | |
| Q15010 | |
| Q3KQZ0 | |
| Q5JUP7 | |
| Q75R47 | |
| Q86XD3 | |
| A2ATN2 |
| PIR ID | S26058 |
|---|
| Unigene ID | Hs.654530 |
|---|---|
| Mm.289686 | |
| Rn.101794 |
| KEGG ID | hsa:8021 |
|---|---|
| mmu:227720 | |
| rno:296634 |
| Swiss-Prot ID | NU214_HUMAN |
|---|---|
| NU214_MOUSE |
| Ensembl ID | ENSG00000126883 |
|---|---|
| ENSP00000352400 | |
| ENST00000359428 | |
| ENSP00000405014 | |
| ENST00000451030 | |
| ENSP00000396576 | |
| ENST00000411637 | |
| ENSMUSG00000001855 | |
| ENSMUSP00000066492 | |
| ENSMUST00000065398 |
| Homologene ID | 38008 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 1095411 |
|---|
| RGD ID | 1304977 |
|---|
| MedScan ID | 8021 |
|---|