| URN | urn:agi-llid:1971 |
|---|---|
| Total Entities | 0 |
| Connectivity | 125 |
| Name | Eif6 |
| Description | eukaryotic translation initiation factor 6 |
| Notes | Hemidesmosomes are structures which link the basal lamina to the intermediate filament cytoskeleton. An important functional component of hemidesmosomes is the integrin beta-4 subunit (ITGB4), a protein containing two fibronectin type III domains. The protein encoded by this gene binds to the fibronectin type III domains of ITGB4 and may help link ITGB4 to the intermediate filament cytoskeleton. The encoded protein, which is insoluble and found both in the nucleus and in the cytoplasm, can function as a translation initiation factor and prevent the association of the 40S and 60S ribosomal subunits. Multiple non-protein coding transcript variants and variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2012] |
| GO Molecular Function | translation initiation factor activity |
|---|---|
| ribosome binding |
| GO Cellular Component | lamin filament |
|---|---|
| nucleolus | |
| intermediate filament | |
| cytoplasm | |
| nucleus |
| GO Biological Process | integrin-mediated signaling pathway |
|---|---|
| translational initiation | |
| translation | |
| mature ribosome assembly | |
| ribosome biogenesis |
| Pathway | ribosome biogenesis pathway |
|---|
| Group | integrin-mediated signaling pathway |
|---|---|
| translational initiation | |
| translation initiation factor activity | |
| translation | |
| mature ribosome assembly | |
| ribosome biogenesis | |
| ribosome binding | |
| lamin filament | |
| nucleolus | |
| intermediate filament | |
| cytoplasm | |
| nucleus |
| LocusLink ID | 1971 |
|---|---|
| 3692 | |
| 16418 |
| Cell Localization | Cytoplasm |
|---|---|
| Nucleus | |
| Nucleolus |
| GO ID | 0043022 |
|---|---|
| 0003743 | |
| 0042256 | |
| 0005737 | |
| 0005638 | |
| 0005730 | |
| 0005634 | |
| 0007229 | |
| 0042254 | |
| 0006412 | |
| 0006413 | |
| 0005882 |
| Alias | CAB |
|---|---|
| EIF3A | |
| eIF-6 | |
| p27BBP | |
| ITGB4BP | |
| b(2)gcn | |
| p27(BBP) | |
| RP4-614O4.1 | |
| eukaryotic translation initiation factor 6 | |
| B4 integrin interactor | |
| p27 beta-4 integrin-binding protein | |
| eukaryotic translation initiation factor 3A | |
| imc-415 | |
| AA408895 | |
| 1110004P11 | |
| RP23-388H13.5 | |
| integrin beta 4 binding protein | |
| integrin beta 4-binding protein | |
| OTTHUMP00000061361 | |
| OTTHUMP00000030734 | |
| OTTHUMP00000061360 | |
| OTTMUSP00000017338 | |
| B(2)GCN homolog | |
| b(2)gcns | |
| Eukaryotic translation initiating factor 6 | |
| MGC124669 | |
| Eukaryotic translation initiating factor VI | |
| EIF6 | |
| Eukaryotic translation initiation factor VI |
| Mouse chromosome position | 2 |
|---|
| OMIM ID | 602912 |
|---|
| Hugo ID | 6159 |
|---|
| Human chromosome position | 20q12 |
|---|
| Swiss-Prot Accession | P56537 |
|---|---|
| O55135 | |
| Q545K4 | |
| B7ZBG9 | |
| Q6IBN8 | |
| Q96TD5 |
| Unigene ID | Hs.743992 |
|---|---|
| Mm.271674 |
| KEGG ID | hsa:3692 |
|---|---|
| mmu:16418 |
| Swiss-Prot ID | IF6_MOUSE |
|---|---|
| IF6_HUMAN |
| EC Number | 3.6.5.3 |
|---|
| Ensembl ID | ENSG00000242372 |
|---|---|
| ENSP00000363574 | |
| ENST00000374450 | |
| ENSP00000363566 | |
| ENST00000374443 | |
| ENSP00000363559 | |
| ENST00000374436 | |
| ENSMUSG00000027613 | |
| ENSMUSP00000029142 | |
| ENSMUST00000029142 |
| Homologene ID | 7135 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus |
| MGI ID | 1196288 |
|---|
| RGD ID | 1305373 |
|---|
| MedScan ID | 1971 |
|---|