| URN | urn:agi-llid:5579 |
|---|---|
| Total Entities | 0 |
| Connectivity | 1496 |
| Name | Prkcb |
| Description | protein kinase C, beta 1 |
| Notes | plays a role in hexosamine biosynthesis pathway induced transcriptional regulation [RGD] |
| GO Molecular Function | histone kinase activity (H3-T6 specific) |
|---|---|
| calcium channel regulator activity | |
| ligand-dependent nuclear receptor transcription coactivator activity | |
| transferase activity | |
| transferase activity, transferring phosphorus-containing groups | |
| kinase activity | |
| protein kinase activity | |
| protein serine-threonine kinase activity | |
| protein kinase C activity | |
| chromatin binding | |
| histone binding | |
| androgen receptor binding | |
| protein kinase C binding | |
| nucleotide binding | |
| ATP binding | |
| metal ion binding | |
| zinc ion binding |
| GO Cellular Component | membrane |
|---|---|
| brush border membrane | |
| centrosome | |
| plasma membrane | |
| cytoplasm | |
| cytosol | |
| nucleus |
| GO Biological Process | immune system process |
|---|---|
| B cell receptor signaling pathway | |
| positive regulation of B cell receptor signaling pathway | |
| B cell activation | |
| histone H3-T6 phosphorylation | |
| dibenzo-p-dioxin metabolic process | |
| blood coagulation | |
| platelet activation | |
| positive regulation of angiogenesis | |
| positive regulation of odontogenesis of dentin-containing tooth | |
| signal transduction | |
| intracellular signal transduction | |
| positive regulation of I-kappaB kinase-NF-kappaB signaling | |
| positive regulation of vascular endothelial growth factor receptor signaling pathway | |
| negative regulation of insulin receptor signaling pathway | |
| synaptic transmission | |
| regulation of dopamine secretion | |
| cellular calcium ion homeostasis | |
| apoptotic process | |
| lipoprotein transport | |
| calcium ion transport | |
| negative regulation of glucose transport | |
| response to drug | |
| cellular response to carbohydrate stimulus | |
| response to glucose | |
| response to vitamin D | |
| response to ethanol | |
| regulation of growth | |
| regulation of transcription, DNA-templated | |
| positive regulation of NF-kappaB transcription factor activity | |
| regulation of transcription from RNA polymerase II promoter | |
| transcription, DNA-templated | |
| protein phosphorylation | |
| phosphorylation | |
| chromatin modification |
| Pathway | Proteins Involved in Pathogenesis of Diffuse Large-B-cell Lymphoma |
|---|---|
| Mantle Cell Lymphoma Overview | |
| PI3K/AKT/MTOR, NF-kB and BCR Signaling Deregulation in Mantle Cell Lymphoma | |
| Mucosa-Associated Lymphoid Tissue (MALT) Lymphoma Overview | |
| Splenic Marginal Zone Lymphoma Overview | |
| Proliferative Diabetic Retinopathy | |
| Role of Protein Kinase C in Diabetic Microangiopathy | |
| Peripheral Tissue Microangiopathy in Insulin Resistance | |
| Overt Hypothyroidism Influence on Thyroid-Stimulating Hormone Secretion | |
| Central Hypothyroidism Overview | |
| Tertiary Hypothyroidism Overview | |
| Proteins Involved in Pathogenesis of Melanoma | |
| B-cell Activation in Systemic Lupus Erythematosus | |
| T-cell-Dependent B-cell Activation | |
| T-cell-Independent B-cell Activation | |
| Mast Cells in Atopic Dermatitis | |
| Proteins Involved in Pathogenesis of Glioma | |
| B-cells Function in Systemic Scleroderma | |
| Proteins Involved in Pathogenesis of Myocardial Ischemia | |
| Role of Scavenger Receptor OLR1 in Inflammation-Related Endothelial Dysfunction in Atherosclerosis | |
| vascular endothelial growth factor signaling pathway | |
| ribosome biogenesis pathway |
| Group | PKC |
|---|---|
| immune system process | |
| B cell receptor signaling pathway | |
| positive regulation of B cell receptor signaling pathway | |
| B cell activation | |
| histone kinase activity (H3-T6 specific) | |
| histone H3-T6 phosphorylation | |
| dibenzo-p-dioxin metabolic process | |
| blood coagulation | |
| platelet activation | |
| positive regulation of angiogenesis | |
| positive regulation of odontogenesis of dentin-containing tooth | |
| signal transduction | |
| intracellular signal transduction | |
| positive regulation of I-kappaB kinase-NF-kappaB signaling | |
| positive regulation of vascular endothelial growth factor receptor signaling pathway | |
| negative regulation of insulin receptor signaling pathway | |
| synaptic transmission | |
| regulation of dopamine secretion | |
| calcium channel regulator activity | |
| cellular calcium ion homeostasis | |
| apoptotic process | |
| lipoprotein transport | |
| calcium ion transport | |
| negative regulation of glucose transport | |
| response to drug | |
| cellular response to carbohydrate stimulus | |
| response to glucose | |
| response to vitamin D | |
| response to ethanol | |
| regulation of growth | |
| regulation of transcription, DNA-templated | |
| ligand-dependent nuclear receptor transcription coactivator activity | |
| positive regulation of NF-kappaB transcription factor activity | |
| regulation of transcription from RNA polymerase II promoter | |
| transferase activity | |
| transferase activity, transferring phosphorus-containing groups | |
| kinase activity | |
| protein kinase activity | |
| protein serine-threonine kinase activity | |
| protein kinase C activity | |
| transcription, DNA-templated | |
| protein phosphorylation | |
| phosphorylation | |
| chromatin modification | |
| chromatin binding | |
| histone binding | |
| androgen receptor binding | |
| protein kinase C binding | |
| nucleotide binding | |
| ATP binding | |
| metal ion binding | |
| zinc ion binding | |
| membrane | |
| brush border membrane | |
| centrosome | |
| plasma membrane | |
| cytoplasm | |
| cytosol | |
| nucleus | |
| Proteins Involved in Pathogenesis of Graves Ophthalmopathy | |
| Secreted proteins |
| LocusLink ID | 5579 |
|---|---|
| 18751 | |
| 25023 |
| Cell Localization | Cytoplasm |
|---|---|
| Nucleus | |
| Membrane |
| GO ID | 0005524 |
|---|---|
| 0050681 | |
| 0005246 | |
| 0003682 | |
| 0042393 | |
| 0035403 | |
| 0030374 | |
| 0004697 | |
| 0005080 | |
| 0004674 | |
| 0008270 | |
| 0042113 | |
| 0050853 | |
| 0006915 | |
| 0007596 | |
| 0006816 | |
| 0006874 | |
| 0071322 | |
| 0035408 | |
| 0035556 | |
| 0042953 | |
| 0010829 | |
| 0046627 | |
| 0030168 | |
| 0050861 | |
| 0043123 | |
| 0051092 | |
| 0045766 | |
| 0030949 | |
| 0006468 | |
| 0006357 | |
| 0007165 | |
| 0007268 | |
| 0006351 | |
| 0005737 | |
| 0005829 | |
| 0005634 | |
| 0005886 | |
| 0016301 | |
| 0046872 | |
| 0000166 | |
| 0004672 | |
| 0016740 | |
| 0016772 | |
| 0016568 | |
| 0002376 | |
| 0016310 | |
| 0014059 | |
| 0040008 | |
| 0006355 | |
| 0042493 | |
| 0031526 | |
| 0005813 | |
| 0016020 | |
| 0018894 | |
| 0042488 | |
| 0045471 | |
| 0009749 | |
| 0033280 | |
| 0005509 | |
| 0019992 | |
| 0007242 | |
| 0005515 | |
| 0005624 | |
| 0005625 | |
| 0004713 |
| Alias | PKCB |
|---|---|
| PRKCB1 | |
| PRKCB2 | |
| PKC-beta | |
| protein kinase C beta type | |
| PKC-B | |
| protein kinase C, beta 1 polypeptide | |
| A130082F03Rik | |
| protein kinase C beta-II | |
| protein kinase C, beta 1 | |
| protein kinase C beta I | |
| protein kinase C beta II | |
| pkcbi | |
| PRKCB | |
| Prkcb I | |
| protein kinase C, beta 2 | |
| PKCbetaI | |
| PKCbetaII | |
| RIKEN cDNA A130082F03 gene | |
| protein kinase C beta | |
| MGC41878 | |
| pkcbii | |
| PKC-beta-2 | |
| A130082F03 | |
| beta2-PKC | |
| OTTMUSP00000017803 | |
| OTTMUSP00000017804 | |
| PKC beta I | |
| PKC beta II | |
| PKC-beta-1 | |
| protein kinase C, beta | |
| PKCbeta II | |
| protein kinase C, beta II | |
| Prkcb Is | |
| Prkcb1s | |
| PRKCB2s | |
| Protein kinase C, beta-I type | |
| PKC-beta I | |
| betaIIPKC |
| Mouse chromosome position | 7 65.75 cM |
|---|---|
| 7 60.0 cM |
| OMIM ID | 176970 |
|---|
| Rat chromosome position | 1q36 |
|---|
| Hugo ID | 9395 |
|---|
| Human chromosome position | 16p11.2 |
|---|
| Swiss-Prot Accession | P05771 |
|---|---|
| P68404 | |
| P68403 | |
| A0JNZ5 | |
| F2Z441 | |
| P04410 | |
| P04411 | |
| C5IFJ8 | |
| D3DWF5 | |
| O43744 | |
| P05127 | |
| Q15138 | |
| Q93060 | |
| Q9UE49 | |
| Q9UE50 | |
| Q9UEH8 | |
| Q9UJ30 | |
| Q9UJ33 |
| PIR ID | S11213 |
|---|---|
| B24664 | |
| S00159 | |
| A00622 |
| Unigene ID | Hs.460355 |
|---|---|
| Mm.207496 | |
| Mm.446371 | |
| Rn.91118 |
| KEGG ID | hsa:5579 |
|---|---|
| mmu:18751 | |
| rno:25023 |
| Swiss-Prot ID | KPCB_MOUSE |
|---|---|
| KPCB_HUMAN | |
| KPCB_RAT |
| EC Number | 2.7.11.13 |
|---|
| Ensembl ID | ENSG00000166501 |
|---|---|
| ENSP00000305355 | |
| ENST00000303531 | |
| ENSP00000318315 | |
| ENST00000321728 | |
| ENSMUSG00000052889 | |
| ENSMUSP00000064812 | |
| ENSMUST00000064921 | |
| ENSRNOG00000012061 | |
| ENSRNOP00000016417 | |
| ENSRNOT00000016418 | |
| ENSRNOP00000016442 | |
| ENSRNOT00000016442 |
| Homologene ID | 56424 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 97596 |
|---|
| RGD ID | 3396 |
|---|
| MedScan ID | 5579 |
|---|