| URN | urn:agi-llid:5234 |
|---|---|
| Connectivity | 27 |
| Name | Sdhd |
| Description | succinate dehydrogenase complex, subunit D, integral membrane protein |
| Notes | Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The subunit D protein is one of two integral membrane proteins anchoring the complex to the matrix side of the membrane. Mutations in SDHD have been linked to hereditary paraganglioma. [provided by RefSeq] |
| Pathway | renal cell cancer pathway |
|---|
| GO Molecular Function | electron carrier activity |
|---|---|
| heme binding | |
| ubiquinone binding | |
| metal ion binding | |
| iron ion binding | |
| succinate dehydrogenase activity |
| GO Cellular Component | membrane |
|---|---|
| mitochondrion | |
| mitochondrial inner membrane | |
| mitochondrial respiratory chain complex II | |
| mitochondrial envelope | |
| integral to membrane |
| GO Biological Process | transport |
|---|---|
| electron transport chain | |
| tricarboxylic acid cycle |
| Ariadne Ontology | Respiratory chain |
|---|---|
| Tricarboxylic acid cycle |
| Group | Respiratory chain |
|---|---|
| Tricarboxylic acid cycle | |
| electron carrier activity | |
| transport | |
| electron transport chain | |
| tricarboxylic acid cycle | |
| heme binding | |
| ubiquinone binding | |
| metal ion binding | |
| iron ion binding | |
| succinate dehydrogenase activity | |
| membrane | |
| mitochondrion | |
| mitochondrial inner membrane | |
| mitochondrial respiratory chain complex II | |
| mitochondrial envelope | |
| integral to membrane |
| MedScan ID | 5234 |
|---|
| Hugo ID | 10683 |
|---|
| Human chromosome position | 11q23 |
|---|
| LocusLink ID | 5234 |
|---|---|
| 6392 | |
| 66925 | |
| 363061 |
| Alias | PGL |
|---|---|
| CBT1 | |
| PGL1 | |
| SDH4 | |
| succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial | |
| QPs3 | |
| cybS | |
| CII-4 | |
| succinate dehydrogenase complex subunit D | |
| succinate-ubiquinone reductase membrane anchor subunit | |
| succinate dehydrogenase ubiquinone cytochrome B small subunit | |
| succinate-ubiquinone oxidoreductase cytochrome b small subunit | |
| C78570 | |
| AVLL5809 | |
| PRO19626 | |
| 3110001M13Rik | |
| UNQ5809 | |
| MGC72971 | |
| 3110001M13 | |
| CBT I | |
| CII IV | |
| LOC91899 | |
| paraganglioma or familial glomus tumors 1 | |
| paraganglioma or familial glomus tumours 1 | |
| PGL I | |
| QPS2 | |
| SDHD | |
| Succinate dehydrogenase (ubiquinone) cytochrome B small subunit, mitochond | |
| succinate dehydrogenase complex, subunit D, integral membrane protein |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 602690 |
|---|---|
| 114900 | |
| 612359 | |
| 606864 | |
| 168000 | |
| 171300 |
| Mouse chromosome position | 9 |
|---|
| GO ID | 0009055 |
|---|---|
| 0020037 | |
| 0046872 | |
| 0000104 | |
| 0048039 | |
| 0022900 | |
| 0006810 | |
| 0006099 | |
| 0016021 | |
| 0016020 | |
| 0005740 | |
| 0005743 | |
| 0005749 | |
| 0005739 | |
| 0005506 |
| Rat chromosome position | 8q23 |
|---|
| Swiss-Prot Accession | O14521 |
|---|---|
| Q9CXV1 | |
| Q9D6J9 | |
| Q6PCT8 | |
| A6H629 | |
| Q3UX11 | |
| A6ND90 | |
| B3KQQ8 | |
| Q53XW5 | |
| Q6IRW2 |
| Unigene ID | Hs.356270 |
|---|---|
| Mm.10406 | |
| Rn.3040 |
| KEGG ID | hsa:6392 |
|---|---|
| mmu:66925 | |
| rno:363061 |
| Swiss-Prot ID | DHSD_MOUSE |
|---|---|
| DHSD_RAT | |
| DHSD_HUMAN | |
| A6H629_MOUSE |
| Cell Localization | Mitochondrion inner membrane |
|---|---|
| Mitochondria |
| IPI ID | IPI00187452 |
|---|---|
| IPI00778578 | |
| IPI00297325 | |
| IPI00421434 |
| Homologene ID | 37718 |
|---|
| RGD ID | 735231 |
|---|
| MGI ID | 1914175 |
|---|