| URN | urn:agi-llid:6390 |
|---|---|
| Connectivity | 30 |
| Name | Sdhb |
| Description | succinate dehydrogenase complex, subunit B, iron sulfur (Ip) |
| Notes | Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis. [provided by RefSeq] |
| Pathway | renal cell cancer pathway |
|---|
| GO Molecular Function | electron carrier activity |
|---|---|
| oxidoreductase activity | |
| iron-sulfur cluster binding | |
| ubiquinone binding | |
| metal ion binding | |
| iron ion binding | |
| 2 iron, 2 sulfur cluster binding | |
| 3 iron, 4 sulfur cluster binding | |
| 4 iron, 4 sulfur cluster binding | |
| succinate dehydrogenase (ubiquinone) activity |
| GO Cellular Component | membrane |
|---|---|
| mitochondrion | |
| mitochondrial inner membrane | |
| mitochondrial respiratory chain complex II |
| GO Biological Process | oxidation reduction |
|---|---|
| transport | |
| electron transport chain | |
| succinate metabolic process | |
| respiratory electron transport chain | |
| aerobic respiration | |
| tricarboxylic acid cycle |
| Ariadne Ontology | Respiratory chain |
|---|---|
| Tricarboxylic acid cycle |
| Group | Respiratory chain |
|---|---|
| Tricarboxylic acid cycle | |
| electron carrier activity | |
| oxidation reduction | |
| transport | |
| electron transport chain | |
| succinate metabolic process | |
| respiratory electron transport chain | |
| aerobic respiration | |
| tricarboxylic acid cycle | |
| oxidoreductase activity | |
| iron-sulfur cluster binding | |
| ubiquinone binding | |
| metal ion binding | |
| iron ion binding | |
| 2 iron, 2 sulfur cluster binding | |
| 3 iron, 4 sulfur cluster binding | |
| 4 iron, 4 sulfur cluster binding | |
| succinate dehydrogenase (ubiquinone) activity | |
| membrane | |
| mitochondrion | |
| mitochondrial inner membrane | |
| mitochondrial respiratory chain complex II |
| MedScan ID | 6390 |
|---|
| Hugo ID | 10681 |
|---|
| Human chromosome position | 1p36.1-p35 |
|---|
| LocusLink ID | 6390 |
|---|---|
| 67680 | |
| 298596 |
| Alias | IP |
|---|---|
| SDH | |
| PGL4 | |
| SDH1 | |
| SDH2 | |
| SDHIP | |
| FLJ92337 | |
| succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial | |
| iron-sulfur subunit of complex II | |
| 0710008N11Rik | |
| RP23-183L1.3 | |
| OTTMUSP00000010715 | |
| succinate dehydrogenase complex subunit B | |
| 0710008N11 | |
| LOC96200 | |
| mitochondrial Succinate dehydrogenase (ubiquinone) iron-sulfur protein pr | |
| OTTHUMP00000002396 | |
| OTTHUMP00000044624 | |
| PCHC | |
| Pheochromocytoma gene | |
| SDH I | |
| Sdhb | |
| succinate dehydrogenase complex, subunit B, iron sulfur | |
| succinate dehydrogenase complex, subunit B, iron sulfur (Ip) | |
| succinate dehydrogenase Ip subunit |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 185470 |
|---|---|
| 612359 | |
| 606864 | |
| 115310 | |
| 171300 |
| Mouse chromosome position | 4 |
|---|
| GO ID | 0051537 |
|---|---|
| 0051538 | |
| 0051539 | |
| 0009055 | |
| 0046872 | |
| 0016491 | |
| 0008177 | |
| 0048039 | |
| 0009060 | |
| 0022904 | |
| 0006105 | |
| 0006810 | |
| 0006099 | |
| 0016020 | |
| 0005743 | |
| 0005749 | |
| 0005739 | |
| 0051536 | |
| 0022900 | |
| 0055114 | |
| 0005506 |
| Rat chromosome position | 5q36 |
|---|
| Swiss-Prot Accession | P21912 |
|---|---|
| Q0QEY7 | |
| Q70SX8 | |
| A2AA77 | |
| Q9CQA3 | |
| Q0QEZ4 | |
| Q3TE45 | |
| Q9Z1Z5 | |
| P21913 | |
| B2R545 | |
| Q9NQ12 | |
| Q3TF82 | |
| Q9DC91 | |
| B0BMZ2 | |
| Q0QEZ3 |
| PIR ID | I38895 |
|---|---|
| PT0094 | |
| B32394 |
| Unigene ID | Hs.465924 |
|---|---|
| Mm.246965 | |
| Rn.3902 |
| KEGG ID | hsa:6390 |
|---|---|
| mmu:67680 | |
| rno:298596 |
| EC Number | 1.3.5.1 |
|---|
| Swiss-Prot ID | DHSB_HUMAN |
|---|---|
| DHSB_MOUSE | |
| DHSB_RAT | |
| A2AA77_MOUSE | |
| B2R545_HUMAN |
| Cell Localization | Mitochondrion inner membrane |
|---|---|
| Mitochondria |
| IPI ID | IPI00294911 |
|---|---|
| IPI00338536 | |
| IPI00785564 |
| Homologene ID | 2255 |
|---|
| RGD ID | 1308598 |
|---|
| MGI ID | 1914930 |
|---|