Elsevier Inc. downregulated miRNA ---> upregulated target translation potential RCC miRNA ---> Carcinoma, Renal Cell upregulated miRNA ---> downregulated target translation potential RCC miRNA drug pathways in RCC targeted therapy drug pathways in RCC targeted therapy ---| Carcinoma, Renal Cell other RCC candidate genes Vhl Sdhd Sdhb Fh altered expression of target genes altered hypoxia inducible factor pathway ---> altered expression of target genes other RCC candidate genes ---> Carcinoma, Renal Cell altered hypoxia inducible factor pathway altered citric acid cycle pathway ---> altered hypoxia inducible factor pathway upregulated miRNA downregulated miRNA upregulated target translation downregulated target translation Carcinoma, Renal Cell altered citric acid cycle pathway