| URN | urn:agi-llid:157506 |
|---|---|
| Connectivity | 11 |
| Name | Rdh10 |
| Description | retinol dehydrogenase 10 (all-trans) |
| Notes | RDH10 generates all-trans retinal from all-trans retinol and may plan an important role in the photic visual cycle. All-trans retinal is isomerized to 11-cis retinal by the retinal G protein-coupled receptor (RGR; MIM 600342) when the retinal pigment epithelium (RPE) is illuminated.[supplied by OMIM] |
| Pathway | retinoid cycle metabolic pathway |
|---|
| GO Molecular Function | catalytic activity |
|---|---|
| oxidoreductase activity | |
| retinol dehydrogenase activity |
| GO Cellular Component | membrane |
|---|---|
| cytoplasm | |
| endoplasmic reticulum membrane | |
| endoplasmic reticulum | |
| nucleus | |
| membrane fraction | |
| microsome | |
| integral to membrane |
| GO Biological Process | metabolic process |
|---|---|
| oxidation reduction | |
| organ morphogenesis | |
| gonad development | |
| primary lung bud formation | |
| bud elongation involved in lung branching | |
| embryonic organ development | |
| ear development | |
| nose development | |
| metanephros development | |
| embryonic camera-type eye development | |
| neural crest cell development | |
| embryonic viscerocranium morphogenesis | |
| embryonic forelimb morphogenesis | |
| in utero embryonic development | |
| visual perception | |
| retinal metabolic process | |
| retinol metabolic process | |
| retinoic acid biosynthetic process |
| Group | catalytic activity |
|---|---|
| metabolic process | |
| oxidation reduction | |
| organ morphogenesis | |
| gonad development | |
| primary lung bud formation | |
| bud elongation involved in lung branching | |
| embryonic organ development | |
| ear development | |
| nose development | |
| metanephros development | |
| embryonic camera-type eye development | |
| neural crest cell development | |
| embryonic viscerocranium morphogenesis | |
| embryonic forelimb morphogenesis | |
| in utero embryonic development | |
| visual perception | |
| retinal metabolic process | |
| retinol metabolic process | |
| retinoic acid biosynthetic process | |
| oxidoreductase activity | |
| retinol dehydrogenase activity | |
| membrane | |
| cytoplasm | |
| endoplasmic reticulum membrane | |
| endoplasmic reticulum | |
| nucleus | |
| membrane fraction | |
| microsome | |
| integral to membrane |
| MedScan ID | 157506 |
|---|
| Hugo ID | 19975 |
|---|
| Human chromosome position | 8q21.11 |
|---|
| LocusLink ID | 157506 |
|---|---|
| 98711 | |
| 353252 |
| Alias | SDR16C4 |
|---|---|
| UNQ9375/PRO34191 | |
| retinol dehydrogenase 10 | |
| short chain dehydrogenase/reductase family 16C, member 4 | |
| m366Asp | |
| AI875664 | |
| AW549993 | |
| D1Ertd762e | |
| 3110069K09Rik | |
| 4921506A21Rik | |
| OTTMUSP00000030597 | |
| 3110069K09 | |
| 4921506A21 | |
| DNA segment, Chr 1, ERATO Doi 762, expressed | |
| LOC297754 | |
| RDH10 | |
| retinol dehydrogenase 10 (all-trans) |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 607599 |
|---|
| Mouse chromosome position | 1 12.0 cM |
|---|
| GO ID | 0016491 |
|---|---|
| 0004745 | |
| 0060449 | |
| 0043583 | |
| 0031076 | |
| 0035115 | |
| 0048703 | |
| 0008406 | |
| 0001701 | |
| 0001656 | |
| 0014032 | |
| 0043584 | |
| 0009887 | |
| 0055114 | |
| 0060431 | |
| 0042574 | |
| 0002138 | |
| 0042572 | |
| 0007601 | |
| 0005737 | |
| 0005783 | |
| 0005789 | |
| 0016021 | |
| 0016020 | |
| 0005624 | |
| 0005792 | |
| 0005634 | |
| 0003824 | |
| 0048568 | |
| 0008152 |
| Rat chromosome position | 5q11 |
|---|
| Swiss-Prot Accession | Q8IZV5 |
|---|---|
| Q8VCH7 | |
| Q80ZF7 | |
| Q8CJ68 |
| Unigene ID | Hs.724648 |
|---|---|
| Mm.274376 | |
| Rn.16968 |
| KEGG ID | hsa:157506 |
|---|---|
| mmu:98711 | |
| rno:353252 |
| EC Number | 1.1.1.- |
|---|---|
| 1.1.1.300 |
| Swiss-Prot ID | RDH10_HUMAN |
|---|---|
| RDH10_RAT | |
| RDH10_MOUSE |
| Cell Localization | Microsome membrane |
|---|---|
| Endoplasmic reticulum membrane |
| IPI ID | IPI00218086 |
|---|---|
| IPI00187892 | |
| IPI00122152 |
| Homologene ID | 14061 |
|---|
| RGD ID | 727793 |
|---|
| MGI ID | 1924238 |
|---|