| URN | urn:agi-llid:50700 |
|---|---|
| Connectivity | 3 |
| Name | Rdh8 |
| Description | retinol dehydrogenase 8 (all-trans) |
| Notes | All-trans-retinol dehydrogenase (RDH8) is a visual cycle enzyme that reduces all-trans-retinal to all-trans-retinol in the presence of NADPH (Rattner et al., 2000 [PubMed 10753906]). It is a member of the short chain dehydrogenase/reductase family and is located in the outer segments of photoreceptors; hence it is also known as photoreceptor retinol dehydrogenase. It is important in the visual cycle by beginning the rhodopsin regeneration pathway by reducing all-trans-retinal, the product of bleached and hydrolysed rhodopsin (Rando, 2001 [PubMed 11710234]). This is a rate-limiting step in the visual cycle (Saari et al., 1998 [PubMed 9667000]).[supplied by OMIM] |
| Pathway | retinoid cycle metabolic pathway |
|---|
| GO Molecular Function | oxidoreductase activity |
|---|---|
| retinol dehydrogenase activity | |
| estradiol 17-beta-dehydrogenase activity |
| GO Cellular Component | membrane |
|---|---|
| cytoplasm | |
| integral to plasma membrane |
| GO Biological Process | response to stimulus |
|---|---|
| oxidation reduction | |
| visual perception | |
| retinol metabolic process | |
| estrogen biosynthetic process | |
| steroid biosynthetic process |
| Group | response to stimulus |
|---|---|
| oxidation reduction | |
| visual perception | |
| retinol metabolic process | |
| estrogen biosynthetic process | |
| steroid biosynthetic process | |
| oxidoreductase activity | |
| retinol dehydrogenase activity | |
| estradiol 17-beta-dehydrogenase activity | |
| membrane | |
| cytoplasm | |
| integral to plasma membrane |
| MedScan ID | 50700 |
|---|
| Hugo ID | 14423 |
|---|
| Human chromosome position | 19p13.2-p13.3 |
|---|
| LocusLink ID | 50700 |
|---|---|
| 235033 | |
| 690953 |
| Alias | PRRDH |
|---|---|
| SDR28C2 | |
| retinol dehydrogenase 8 | |
| short chain dehydrogenase/reductase family 28C, member 2 | |
| photoreceptor outer segment all-trans retinol dehydrogenase | |
| Gm182 | |
| LOC687099 | |
| RDH8 | |
| retinol dehydrogenase 8 (all-trans) | |
| retinol dehydrogenase VIII |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 608575 |
|---|
| Mouse chromosome position | 9 |
|---|
| GO ID | 0004303 |
|---|---|
| 0016491 | |
| 0004745 | |
| 0006703 | |
| 0055114 | |
| 0050896 | |
| 0006694 | |
| 0007601 | |
| 0005737 | |
| 0005887 | |
| 0016020 | |
| 0042572 |
| Rat chromosome position | 8q13 |
|---|
| Swiss-Prot Accession | Q9NYR8 |
|---|---|
| Q9H838 |
| Unigene ID | Hs.675522 |
|---|---|
| Mm.297661 | |
| Rn.110636 |
| KEGG ID | hsa:50700 |
|---|---|
| mmu:235033 | |
| rno:690953 |
| EC Number | 1.1.1.300 |
|---|
| Swiss-Prot ID | RDH8_HUMAN |
|---|
| Cell Localization | Membrane |
|---|
| IPI ID | IPI00024598 |
|---|---|
| IPI00355669 | |
| IPI00359823 |
| Homologene ID | 41062 |
|---|
| RGD ID | 1589829 |
|---|
| MGI ID | 2685028 |
|---|