| URN | urn:agi-llid:9227 |
|---|---|
| Connectivity | 26 |
| Name | Lrat |
| Description | lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase) |
| Notes | The protein encoded by this gene is a microsomal enzyme that catalyzes the esterification of all-trans-retinol into all-trans-retinyl ester, an essential reaction for the retinoid cycle in visual system and vitamin A status in liver. Mutations in this gene have been associated with early-onset severe retinal dystrophy. [provided by RefSeq] |
| Pathway | retinoic acid metabolic pathway |
|---|---|
| retinoid cycle metabolic pathway |
| GO Molecular Function | transferase activity |
|---|---|
| retinol binding | |
| retinoic acid binding | |
| acyltransferase activity | |
| O-acyltransferase activity | |
| phosphatidylcholine-retinol O-acyltransferase activity |
| GO Cellular Component | membrane |
|---|---|
| endoplasmic reticulum membrane | |
| endoplasmic reticulum | |
| microsome | |
| integral to membrane |
| GO Biological Process | response to stimulus |
|---|---|
| embryonic development | |
| visual perception | |
| retinol metabolic process | |
| lecithin metabolic process | |
| vitamin A metabolic process |
| Group | response to stimulus |
|---|---|
| embryonic development | |
| visual perception | |
| retinol metabolic process | |
| lecithin metabolic process | |
| vitamin A metabolic process | |
| transferase activity | |
| retinol binding | |
| retinoic acid binding | |
| acyltransferase activity | |
| O-acyltransferase activity | |
| phosphatidylcholine-retinol O-acyltransferase activity | |
| membrane | |
| endoplasmic reticulum membrane | |
| endoplasmic reticulum | |
| microsome | |
| integral to membrane |
| MedScan ID | 9227 |
|---|
| Hugo ID | 6685 |
|---|
| Human chromosome position | 4q32.1 |
|---|
| LocusLink ID | 9227 |
|---|---|
| 79235 | |
| 64047 |
| Alias | LCA14 |
|---|---|
| MGC33103 | |
| lecithin retinol acyltransferase | |
| AI449251 | |
| 1300010A18Rik | |
| phosphatidylcholine-retinol-O-acyltransferase | |
| phosphatidylcholine--retinol O-acyltransferase | |
| lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase) | |
| 1300010A18 | |
| lecithin-retinol acyltransferase (phosphatidylcholine-retinol-O-acyltransferase) | |
| LOC299882 | |
| LOC497758 | |
| Lrat | |
| phosphatidylcholine-retinol O-acyltransferase |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 604863 |
|---|---|
| 613341 |
| Mouse chromosome position | 3 |
|---|
| GO ID | 0008415 |
|---|---|
| 0047173 | |
| 0016740 | |
| 0050896 | |
| 0007601 | |
| 0005783 | |
| 0005789 | |
| 0016021 | |
| 0016020 | |
| 0008374 | |
| 0001972 | |
| 0019841 | |
| 0009790 | |
| 0006653 | |
| 0042572 | |
| 0006776 | |
| 0005792 |
| Rat chromosome position | 2q34 |
|---|
| Swiss-Prot Accession | O95237 |
|---|---|
| B2RUR5 | |
| Q9JI60 | |
| Q9JI61 | |
| A8K983 | |
| Q8N716 |
| Unigene ID | Hs.658427 |
|---|---|
| Mm.33921 | |
| Rn.137431 |
| KEGG ID | hsa:9227 |
|---|---|
| mmu:79235 | |
| rno:64047 |
| EC Number | 2.3.1.135 |
|---|
| Swiss-Prot ID | LRAT_MOUSE |
|---|---|
| LRAT_HUMAN | |
| LRAT_RAT | |
| B2RUR5_MOUSE | |
| A8K983_HUMAN |
| Cell Localization | Endoplasmic reticulum membrane |
|---|
| IPI ID | IPI00119943 |
|---|---|
| IPI00006231 | |
| IPI00199982 | |
| IPI00735216 |
| Homologene ID | 3483 |
|---|
| RGD ID | 68362 |
|---|
| MGI ID | 1891259 |
|---|