| URN | urn:agi-llid:5949 |
|---|---|
| Connectivity | 59 |
| Name | Rbp3 |
| Description | retinol binding protein 3, interstitial |
| Notes | Interphotoreceptor retinol-binding protein is a large glycoprotein known to bind retinoids and found primarily in the interphotoreceptor matrix of the retina between the retinal pigment epithelium and the photoreceptor cells. It is thought to transport retinoids between the retinal pigment epithelium and the photoreceptors, a critical role in the visual process.The human IRBP gene is approximately 9.5 kbp in length and consists of four exons separated by three introns. The introns are 1.6-1.9 kbp long. The gene is transcribed by photoreceptor and retinoblastoma cells into an approximately 4.3-kilobase mRNA that is translated and processed into a glycosylated protein of 135,000 Da. The amino acid sequence of human IRBP can be divided into four contiguous homology domains with 33-38% identity, suggesting a series of gene duplication events. In the gene, the boundaries of these domains are not defined by exon-intron junctions, as might have been expected. The first three homology domains and part of the fourth are all encoded by the first large exon, which is 3,180 base pairs long. The remainder of the fourth domain is encoded in the last three exons, which are 191, 143, and approximately 740 base pairs long, respectively. [provided by RefSeq] |
| Pathway | retinoid cycle metabolic pathway |
|---|
| GO Molecular Function | retinal binding |
|---|---|
| retinoid binding | |
| serine-type peptidase activity |
| GO Cellular Component | extracellular region |
|---|---|
| proteinaceous extracellular matrix | |
| interphotoreceptor matrix |
| GO Biological Process | transport |
|---|---|
| eye photoreceptor cell development | |
| visual perception | |
| lipid metabolic process | |
| proteolysis |
| Group | extracellular region |
|---|---|
| transport | |
| eye photoreceptor cell development | |
| visual perception | |
| lipid metabolic process | |
| proteolysis | |
| retinal binding | |
| retinoid binding | |
| serine-type peptidase activity | |
| proteinaceous extracellular matrix | |
| interphotoreceptor matrix |
| MedScan ID | 5949 |
|---|
| Hugo ID | 9921 |
|---|
| Human chromosome position | 10q11.2 |
|---|
| LocusLink ID | 5949 |
|---|---|
| 19661 | |
| 24711 |
| Alias | IRBP |
|---|---|
| RBPI | |
| D10S64 | |
| D10S65 | |
| D10S66 | |
| retinol-binding protein 3 | |
| interstitial retinol-binding protein | |
| retinol-binding protein 3, interstitial | |
| interphotoreceptor retinoid-binding protein | |
| Rbp-3 | |
| MGC102323 | |
| interphotoreceptor retinoid binding protein | |
| interphotoreceptor retinol- binding protein | |
| interphotoreceptor retinol binding protein | |
| interphotoreceptor retinol-binding protein | |
| interstitial retinoid binding protein | |
| interstitial retinoid-binding protein | |
| Interstitial retinol binding protein | |
| LOC218905 | |
| OTTHUMP00000019536 | |
| Rbp3 | |
| retinol binding protein 3, interstitial | |
| retinol-binding protein-3 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 180290 |
|---|
| Mouse chromosome position | 14 13.0 cM |
|---|
| GO ID | 0016918 |
|---|---|
| 0005501 | |
| 0008236 | |
| 0006629 | |
| 0006508 | |
| 0006810 | |
| 0007601 | |
| 0005576 | |
| 0033165 | |
| 0005578 | |
| 0042462 |
| Rat chromosome position | 16p16 |
|---|
| Swiss-Prot Accession | P10745 |
|---|---|
| Q8IXN0 | |
| P49194 | |
| Q8K1Q2 | |
| Q99301 | |
| Q9R0H6 | |
| Q9R0I0 | |
| Q6B4R6 | |
| Q8VD34 | |
| Q9R0H8 | |
| Q5VSR0 |
| PIR ID | A33812 |
|---|
| Unigene ID | Hs.591928 |
|---|---|
| Mm.436622 | |
| Rn.41214 |
| KEGG ID | hsa:5949 |
|---|---|
| mmu:19661 | |
| rno:24711 |
| Swiss-Prot ID | RET3_MOUSE |
|---|---|
| RET3_HUMAN | |
| Q8IXN0_HUMAN | |
| Q5VSR0_HUMAN |
| Cell Localization | Secreted |
|---|---|
| extracellular space | |
| extracellular matrix | |
| interphotoreceptor matrix |
| IPI ID | IPI00309361 |
|---|---|
| IPI00022337 | |
| IPI00364611 |
| Homologene ID | 9261 |
|---|
| RGD ID | 3545 |
|---|
| MGI ID | 97878 |
|---|