| URN | urn:agi-llid:5950 |
|---|---|
| Connectivity | 70 |
| Name | Rbp4 |
| Description | retinol binding protein 4, plasma |
| Notes | This protein belongs to the lipocalin family and is the specific carrier for retinol (vitamin A alcohol) in the blood. It delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin which prevents its loss by filtration through the kidney glomeruli. A deficiency of vitamin A blocks secretion of the binding protein posttranslationally and results in defective delivery and supply to the epidermal cells. [provided by RefSeq] |
| Pathway | retinoic acid metabolic pathway |
|---|
| GO Molecular Function | transporter activity |
|---|---|
| retinal binding | |
| retinol binding | |
| retinoid binding | |
| retinol transporter activity |
| GO Cellular Component | extracellular region |
|---|---|
| extracellular space |
| GO Biological Process | response to stimulus |
|---|---|
| transmembrane transport | |
| embryonic development | |
| transport | |
| retina development in camera-type eye | |
| negative regulation of cardiac muscle cell proliferation | |
| female genitalia morphogenesis | |
| vagina development | |
| uterus development | |
| male gonad development | |
| heart trabecula formation | |
| urinary bladder development | |
| lung development | |
| heart development | |
| embryonic skeletal system development | |
| eye development | |
| cardiac muscle tissue development | |
| embryonic retina morphogenesis in camera-type eye | |
| embryonic organ morphogenesis | |
| maintenance of gastrointestinal epithelium | |
| spermatogenesis | |
| spermatogonial cell division | |
| positive regulation of insulin secretion | |
| positive regulation of immunoglobulin secretion | |
| retinal metabolic process | |
| retinol metabolic process | |
| gluconeogenesis | |
| response to ethanol | |
| response to insulin stimulus | |
| response to retinoic acid | |
| detection of light stimulus involved in visual perception | |
| retinol transport | |
| glucose homeostasis |
| Group | extracellular region |
|---|---|
| transporter activity | |
| response to stimulus | |
| transmembrane transport | |
| embryonic development | |
| transport | |
| retina development in camera-type eye | |
| negative regulation of cardiac muscle cell proliferation | |
| female genitalia morphogenesis | |
| vagina development | |
| uterus development | |
| male gonad development | |
| heart trabecula formation | |
| urinary bladder development | |
| lung development | |
| heart development | |
| embryonic skeletal system development | |
| eye development | |
| cardiac muscle tissue development | |
| embryonic retina morphogenesis in camera-type eye | |
| embryonic organ morphogenesis | |
| maintenance of gastrointestinal epithelium | |
| spermatogenesis | |
| spermatogonial cell division | |
| positive regulation of insulin secretion | |
| positive regulation of immunoglobulin secretion | |
| retinal metabolic process | |
| retinol metabolic process | |
| gluconeogenesis | |
| response to ethanol | |
| response to insulin stimulus | |
| response to retinoic acid | |
| detection of light stimulus involved in visual perception | |
| retinol transport | |
| glucose homeostasis | |
| retinal binding | |
| retinol binding | |
| retinoid binding | |
| retinol transporter activity | |
| extracellular space |
| MedScan ID | 5950 |
|---|
| Hugo ID | 9922 |
|---|
| Human chromosome position | 10q23-q24 |
|---|
| LocusLink ID | 5950 |
|---|---|
| 19662 | |
| 25703 |
| Alias | PRO2222 |
|---|---|
| retinol-binding protein 4 | |
| RBP | |
| PRBP | |
| OTTHUMP00000020115 | |
| plasma retinol-binding protein | |
| retinol-binding protein 4, interstitial | |
| Rbp-4 | |
| retinol binding protein 4, cellular | |
| RBPA | |
| cellular retinol binding protein 4 | |
| interstitial retinol-binding protein 4 | |
| OTTHUMP00000020114 | |
| OTTHUMP00000020116 | |
| Plasma retinol binding protein | |
| plasma retinol binding protein 4 | |
| Plasma retinol-binding protein precursor | |
| Rbp4 | |
| Retinol binding protein 4 | |
| retinol binding protein 4, plasma | |
| Retinol binding protein IV |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 180250 |
|---|
| Mouse chromosome position | 19 38.0 cM |
|---|
| GO ID | 0016918 |
|---|---|
| 0019841 | |
| 0034632 | |
| 0005215 | |
| 0048738 | |
| 0050908 | |
| 0009790 | |
| 0048562 | |
| 0060059 | |
| 0048706 | |
| 0001654 | |
| 0048807 | |
| 0006094 | |
| 0042593 | |
| 0007507 | |
| 0060347 | |
| 0030324 | |
| 0030277 | |
| 0008584 | |
| 0060044 | |
| 0051024 | |
| 0032024 | |
| 0045471 | |
| 0032868 | |
| 0032526 | |
| 0050896 | |
| 0060041 | |
| 0042574 | |
| 0042572 | |
| 0034633 | |
| 0007283 | |
| 0007284 | |
| 0060157 | |
| 0060065 | |
| 0060068 | |
| 0005576 | |
| 0005615 | |
| 0005501 | |
| 0006810 | |
| 0055085 |
| Rat chromosome position | 1q53 |
|---|
| Swiss-Prot Accession | P02753 |
|---|---|
| Q00724 | |
| Q3TF08 | |
| B2RZC1 | |
| P04916 | |
| P70357 | |
| Q566I5 | |
| O43478 | |
| O43479 | |
| Q5VY24 | |
| Q8WWA3 | |
| Q9P178 | |
| D3DR38 |
| PIR ID | A92493 |
|---|---|
| A93494 |
| Unigene ID | Hs.50223 |
|---|---|
| Mm.2605 | |
| Rn.108214 |
| KEGG ID | hsa:5950 |
|---|---|
| mmu:19662 | |
| rno:25703 |
| Swiss-Prot ID | RET4_MOUSE |
|---|---|
| RET4_RAT | |
| RET4_HUMAN | |
| D3DR38_HUMAN | |
| B2RZC1_RAT |
| Cell Localization | Secreted |
|---|
| IPI ID | IPI00122429 |
|---|---|
| IPI00876581 | |
| IPI00022420 | |
| IPI00844536 | |
| IPI00480192 |
| Homologene ID | 4908 |
|---|
| RGD ID | 3546 |
|---|
| MGI ID | 97879 |
|---|