| URN | urn:agi-llid:1066 |
|---|---|
| Connectivity | 88 |
| Name | CES1 |
| Description | carboxylesterase 1 (monocyte/macrophage serine esterase 1) |
| Notes | This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This enzyme is the major liver enzyme and functions in liver drug clearance. Mutations of this gene cause carboxylesterase 1 deficiency. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq] |
| Pathway | retinoic acid metabolic pathway |
|---|
| GO Molecular Function | hydrolase activity |
|---|---|
| carboxylesterase activity | |
| fatty-acyl-ethyl-ester synthase activity |
| GO Cellular Component | endoplasmic reticulum |
|---|---|
| endoplasmic reticulum lumen |
| GO Biological Process | metabolic process |
|---|---|
| acyl-CoA metabolic process | |
| response to toxin |
| Ariadne Ontology | Cholesterol-isoprenoid metabolism |
|---|
| Group | Cholesterol-isoprenoid metabolism |
|---|---|
| metabolic process | |
| acyl-CoA metabolic process | |
| response to toxin | |
| hydrolase activity | |
| carboxylesterase activity | |
| fatty-acyl-ethyl-ester synthase activity | |
| endoplasmic reticulum | |
| endoplasmic reticulum lumen |
| MedScan ID | 1066 |
|---|
| Hugo ID | 1863 |
|---|
| Human chromosome position | 16q13-q22.1 |
|---|
| LocusLink ID | 1066 |
|---|---|
| 104158 | |
| 113902 | |
| 291863 |
| Alias | CEH |
|---|---|
| TGH | |
| ACAT | |
| CES2 | |
| HMSE | |
| SES1 | |
| HMSE1 | |
| PCE-1 | |
| MGC117365 | |
| liver carboxylesterase 1 | |
| REH | |
| egasyn | |
| serine esterase 1 | |
| retinyl ester hydrolase | |
| cocaine carboxylesterase | |
| triacylglycerol hydrolase | |
| carboxylesterase 2 (liver) | |
| brain carboxylesterase hBr1 | |
| cholesteryl ester hydrolase | |
| monocyte/macrophage serine esterase | |
| acyl coenzyme A:cholesterol acyltransferase | |
| acyl-coenzyme A:cholesterol acyltransferase | |
| carboxylesterase 3 | |
| FAEE synthase | |
| OTTMUSP00000029377 | |
| fatty acid ethyl ester synthase | |
| ES-HVEL | |
| pI 6.1 esterase | |
| carboxyesterase ES-10 | |
| liver carboxylesterase 10 | |
| carboxylesterase-like | |
| Ces1 | |
| carboxylestease 2 (liver) | |
| carboxylesterase (Rattus rattus) | |
| carboxylesterase 1 | |
| carboxylesterase 1 (monocyte/macrophage serine esterase 1) | |
| carboxylesterase I | |
| carboxylesterase precursor (Macaca fascicularis) | |
| Ces I | |
| ces1a1 | |
| egasyn esterase | |
| esterase 22 | |
| HMSE I | |
| liver carboxylesterase | |
| liver carboxylesterase (Oryctolagus cuniculus) | |
| LOC291863 | |
| MGC18894 | |
| microsomal carboxyesterase E1 | |
| monocyte/macrophage serine esterase 1 | |
| monocyte/macrophage serine esterase I | |
| Serine esterase I |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 114835 |
|---|
| Mouse chromosome position | 8 |
|---|
| GO ID | 0004091 |
|---|---|
| 0016787 | |
| 0008152 | |
| 0009636 | |
| 0005783 | |
| 0005788 | |
| 0030339 | |
| 0006637 |
| Rat chromosome position | 19p11 |
|---|---|
| 19p12 |
| Swiss-Prot Accession | P23141 |
|---|---|
| Q6LAP9 | |
| Q8VCT4 | |
| P16303 | |
| Q68G49 | |
| Q91ZV9 | |
| Q924V8 | |
| Q9ULY1 | |
| A6NIM1 | |
| A8K3K8 | |
| A8K844 | |
| P82127 | |
| Q00015 | |
| Q13657 | |
| Q14062 | |
| Q16737 | |
| Q16788 | |
| Q549X7 | |
| Q549X8 | |
| Q86UK2 | |
| Q96EE8 | |
| Q9UC52 | |
| Q9UDG8 | |
| Q9UK77 | |
| Q9ULY2 | |
| Q64574 | |
| Q6P785 | |
| Q91YG2 | |
| Q9QUX7 | |
| Q9R135 |
| PIR ID | A41010 |
|---|---|
| A45140 | |
| S10367 |
| Unigene ID | Hs.558865 |
|---|---|
| Mm.292803 | |
| Rn.2549 | |
| Rn.155930 |
| KEGG ID | hsa:1066 |
|---|---|
| mmu:104158 | |
| rno:113902 | |
| rno:291863 |
| EC Number | 3.1.1.1 |
|---|---|
| 3.1.1.67 |
| Swiss-Prot ID | CES3_MOUSE |
|---|---|
| EST1_HUMAN | |
| CES3_RAT | |
| Q68G49_RAT |
| Cell Localization | Endoplasmic reticulum lumen |
|---|---|
| Endoplasmic reticulum |
| IPI ID | IPI00387289 |
|---|---|
| IPI00010180 | |
| IPI00607801 | |
| IPI00326972 | |
| IPI00361944 | |
| IPI00914996 | |
| IPI00896507 | |
| IPI00745731 | |
| IPI00607693 |
| RGD ID | 1352960 |
|---|
| MGI ID | 2148202 |
|---|