Ariadne Genomics Inc. retinal dehydrogenases circ_retinol ---> cell_retinol atRA CYPs retinoic acid signaling pathway retinyl esters all-trans retinoic acid retinol dehydrogenases CES1 Lrat all-trans retinoic acid ---> atRA CYPs all-trans retinoic acid ---> retinoic acid signaling pathway retinal Stra6 Ttr Rbp4 Crabp2 apo_Rbp1 apo_Rbp1 ---| Lrat retinyl esters ---> cell_retinol Rbp1 Fabp5 all-trans retinoic acid ---> retinoic acid signaling pathway all-trans retinoic acid ---- Crabp2 all-trans retinoic acid ---- Fabp5 atRAs catabolism all-trans retinoic acid ---- Crabp1 retinal ---> all-trans retinoic acid Rbp4 ---- Stra6 cell_retinol ---- Rbp1 Rbp1 ---- retinal retinal <--> cell_retinol circ_retinol ---- Ttr circ_retinol ---- Rbp4 Rbp4 ---- Ttr cell_retinol ---> retinyl esters apo_Rbp1 --+> CES1 circ_retinol cell_retinol Crabp1