| URN | urn:agi-llid:1259 |
|---|---|
| Connectivity | 12 |
| Name | Cnga1 |
| Description | cyclic nucleotide gated channel alpha 1 |
| Notes | The protein encoded by this gene is involved in phototransduction. Along with another protein, the encoded protein forms a cGMP-gated cation channel in the plasma membrane, allowing depolarization of rod photoreceptors. This represents the last step in the phototransduction pathway. Defects in this gene are a cause of retinitis pigmentosa autosomal recessive (ARRP) disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] |
| Pathway | visual phototransduction pathway |
|---|
| GO Molecular Function | nucleotide binding |
|---|---|
| cGMP binding | |
| ion channel activity | |
| intracellular cyclic nucleotide activated cation channel activity |
| GO Cellular Component | membrane |
|---|---|
| cytoplasm | |
| membrane fraction | |
| integral to membrane | |
| integral to plasma membrane | |
| intracellular cyclic nucleotide activated cation channel complex | |
| photoreceptor outer segment |
| GO Biological Process | response to stimulus |
|---|---|
| transmembrane transport | |
| transport | |
| visual perception | |
| spermatogenesis | |
| ion transport |
| Ariadne Ontology | Non-voltage K+ efflux |
|---|---|
| Non-voltage Na+ influx |
| Group | Non-voltage K+ efflux |
|---|---|
| Non-voltage Na+ influx | |
| response to stimulus | |
| transmembrane transport | |
| transport | |
| visual perception | |
| spermatogenesis | |
| ion transport | |
| nucleotide binding | |
| cGMP binding | |
| ion channel activity | |
| intracellular cyclic nucleotide activated cation channel activity | |
| membrane | |
| cytoplasm | |
| membrane fraction | |
| integral to membrane | |
| integral to plasma membrane | |
| intracellular cyclic nucleotide activated cation channel complex | |
| photoreceptor outer segment |
| MedScan ID | 1259 |
|---|
| Hugo ID | 2148 |
|---|
| Human chromosome position | 4p12-cen |
|---|
| LocusLink ID | 1259 |
|---|---|
| 12788 | |
| 85259 |
| Alias | CNCG |
|---|---|
| CNG1 | |
| RP49 | |
| CNCG1 | |
| RCNC1 | |
| RCNCa | |
| RCNCalpha | |
| cGMP-gated cation channel alpha-1 | |
| CNG-1 | |
| CNG channel alpha-1 | |
| interleukin-1 homologue | |
| cyclic nucleotide-gated channel alpha-1 | |
| cyclic nucleotide-gated cation channel 1 | |
| cyclic nucleotide-gated channel, photoreceptor | |
| rod photoreceptor cGMP-gated channel subunit alpha | |
| cyclic nucleotide gated channel, cGMP gated | |
| HCN | |
| cGMP-gated cation channel alpha 1 | |
| cGMP-gated cation channel alpha I | |
| CNCG I | |
| CNG channel alpha 1 | |
| CNG channel alpha I | |
| CNG I | |
| CNGA I | |
| CNGA1 | |
| Cyclic nucleotide gated channel alpha 1 | |
| Cyclic nucleotide gated channel alpha I | |
| Cyclic-nucleotide-gated cation channel 1 | |
| Cyclic-nucleotide-gated cation channel I | |
| RCNC I | |
| Rod photoreceptor cGMP-gated channel alpha subunit |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 123825 |
|---|
| Mouse chromosome position | 5 41.0 cM |
|---|
| GO ID | 0030553 |
|---|---|
| 0005216 | |
| 0000166 | |
| 0006811 | |
| 0050896 | |
| 0007283 | |
| 0055085 | |
| 0006810 | |
| 0007601 | |
| 0005737 | |
| 0005887 | |
| 0017071 | |
| 0016020 | |
| 0005624 | |
| 0001750 | |
| 0016021 | |
| 0005221 |
| Rat chromosome position | 14p11 |
|---|
| Swiss-Prot Accession | P29973 |
|---|---|
| Q4W5E3 | |
| Q08124 | |
| P29974 | |
| Q5U408 | |
| Q62927 | |
| P70607 | |
| O08659 | |
| B9EJ09 | |
| Q60776 | |
| A8K7K6 | |
| Q16279 | |
| Q16485 |
| PIR ID | A42161 |
|---|
| Unigene ID | Hs.1323 |
|---|---|
| Mm.436652 | |
| Rn.54534 |
| KEGG ID | hsa:1259 |
|---|---|
| mmu:12788 | |
| rno:85259 |
| Swiss-Prot ID | CNGA1_RAT |
|---|---|
| CNGA1_MOUSE | |
| CNGA1_HUMAN | |
| Q4W5E3_HUMAN | |
| A8K7K6_HUMAN | |
| B9EJ09_MOUSE |
| Cell Localization | Membrane |
|---|---|
| Plasma membrane |
| IPI ID | IPI00327283 |
|---|---|
| IPI00131211 | |
| IPI00218428 | |
| IPI00902617 | |
| IPI00881980 |
| Homologene ID | 55432 |
|---|
| RGD ID | 621815 |
|---|
| MGI ID | 88436 |
|---|