| URN | urn:agi-llid:44 |
|---|---|
| Connectivity | 14 |
| Name | Cnga3 |
| Description | cyclic nucleotide gated channel alpha 3 |
| Notes | This gene encodes a member of the cyclic nucleotide-gated cation channel protein family which is required for normal vision and olfactory signal transduction. Mutations in this gene are associated with achromatopsia (rod monochromacy) and color blindness. Two alternatively spliced transcripts encoding different isoforms have been described. [provided by RefSeq] |
| Pathway | visual phototransduction pathway |
|---|
| GO Molecular Function | signal transducer activity |
|---|---|
| nucleotide binding | |
| cGMP binding | |
| ion channel activity | |
| ligand-gated ion channel activity | |
| intracellular cyclic nucleotide activated cation channel activity | |
| intracellular cGMP activated cation channel activity |
| GO Cellular Component | membrane |
|---|---|
| integral to membrane | |
| photoreceptor outer segment |
| GO Biological Process | response to stimulus |
|---|---|
| transmembrane transport | |
| transport | |
| visual perception | |
| signal transduction | |
| response to cAMP | |
| response to magnesium ion | |
| response to corticosteroid stimulus | |
| ion transport |
| Ariadne Ontology | Non-voltage K+ efflux |
|---|---|
| Non-voltage Na+ influx |
| Group | Non-voltage K+ efflux |
|---|---|
| Non-voltage Na+ influx | |
| response to stimulus | |
| transmembrane transport | |
| transport | |
| visual perception | |
| signal transduction | |
| response to cAMP | |
| response to magnesium ion | |
| response to corticosteroid stimulus | |
| ion transport | |
| signal transducer activity | |
| nucleotide binding | |
| cGMP binding | |
| ion channel activity | |
| ligand-gated ion channel activity | |
| intracellular cyclic nucleotide activated cation channel activity | |
| intracellular cGMP activated cation channel activity | |
| membrane | |
| integral to membrane | |
| photoreceptor outer segment |
| MedScan ID | 44 |
|---|
| Hugo ID | 2150 |
|---|
| Human chromosome position | 2q11.2 |
|---|
| LocusLink ID | 44 |
|---|---|
| 1261 | |
| 12790 | |
| 85257 |
| Alias | CNG3 |
|---|---|
| ACHM2 | |
| CCNC1 | |
| CCNCa | |
| CNCG3 | |
| CCNCalpha | |
| cyclic nucleotide-gated cation channel alpha-3 | |
| CNG-3 | |
| OTTHUMP00000161120 | |
| OTTHUMP00000203133 | |
| CNG channel alpha-3 | |
| cyclic nucleotide-gated channel alpha-3 | |
| cone photoreceptor cGMP-gated channel alpha subunit | |
| cone photoreceptor cGMP-gated channel subunit alpha | |
| OTTMUSP00000029513 | |
| cyclic nucleotide gated channel alpha 3 | |
| achromatopsia (rod monochromacy) 2 | |
| CCNC I | |
| CNG channel alpha 3 | |
| CNG channel alpha III | |
| Cnga3 | |
| Cyclic nucleotide gated channel alpha III | |
| Cyclic-nucleotide-gated cation channel alpha 3 | |
| Cyclic-nucleotide-gated cation channel alpha III |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 600053 |
|---|---|
| 216900 |
| Mouse chromosome position | 1 |
|---|
| GO ID | 0030553 |
|---|---|
| 0015276 | |
| 0000166 | |
| 0006811 | |
| 0050896 | |
| 0007165 | |
| 0055085 | |
| 0006810 | |
| 0007601 | |
| 0016021 | |
| 0016020 | |
| 0005221 | |
| 0005216 | |
| 0051591 | |
| 0032026 | |
| 0001750 | |
| 0005223 | |
| 0004871 | |
| 0031960 |
| Rat chromosome position | 9q21 |
|---|
| Swiss-Prot Accession | Q4VAP7 |
|---|---|
| Q16281 | |
| Q6ZNA7 | |
| Q8CFV6 | |
| Q9JJZ8 | |
| Q9QWN7 | |
| P97627 | |
| Q9ER32 | |
| Q9ER33 | |
| Q9QX26 | |
| Q53RD2 | |
| Q9UP64 |
| PIR ID | I78560 |
|---|---|
| S74179 |
| Unigene ID | Hs.234785 |
|---|---|
| Mm.214224 | |
| Rn.10886 |
| KEGG ID | hsa:1261 |
|---|---|
| mmu:12790 | |
| rno:85257 |
| Swiss-Prot ID | CNGA3_HUMAN |
|---|---|
| Q4VAP7_HUMAN | |
| Q9QWN7_RAT | |
| Q8CFV6_MOUSE |
| Cell Localization | Membrane |
|---|---|
| Plasma membrane |
| IPI ID | IPI00000812 |
|---|---|
| IPI00816511 | |
| IPI00190422 | |
| IPI00229409 | |
| IPI00442261 | |
| IPI00122446 | |
| IPI00856786 | |
| IPI00780204 | |
| IPI00776808 | |
| IPI00777256 | |
| IPI00778973 | |
| IPI00781076 | |
| IPI00781859 |
| Homologene ID | 994 |
|---|
| RGD ID | 70948 |
|---|
| MGI ID | 1341818 |
|---|