| URN | urn:agi-llid:131890 |
|---|---|
| Connectivity | 9 |
| Name | GRK7 |
| Description | G protein-coupled receptor kinase 7 |
| Notes | This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. It is specifically expressed in the retina and the encoded protein has been shown to phosphorylate cone opsins and initiate their deactivation. [provided by RefSeq] |
| Pathway | visual phototransduction pathway |
|---|
| GO Molecular Function | signal transducer activity |
|---|---|
| nucleotide binding | |
| transferase activity | |
| ATP binding | |
| G-protein coupled receptor kinase activity |
| GO Cellular Component | membrane |
|---|
| GO Biological Process | response to stimulus |
|---|---|
| visual perception | |
| signal transduction | |
| protein amino acid phosphorylation |
| Ariadne Ontology | GRK |
|---|
| Group | GRK |
|---|---|
| response to stimulus | |
| visual perception | |
| signal transduction | |
| protein amino acid phosphorylation | |
| signal transducer activity | |
| nucleotide binding | |
| transferase activity | |
| ATP binding | |
| G-protein coupled receptor kinase activity | |
| membrane |
| MedScan ID | 131890 |
|---|
| Hugo ID | 17031 |
|---|
| Human chromosome position | 3q21-q23 |
|---|
| LocusLink ID | 131890 |
|---|
| Alias | GPRK7 |
|---|---|
| G protein-coupled receptor kinase 7 | |
| g protein-coupled receptor kinase GRK7 | |
| G protein receptor kinase 7 | |
| G protein-coupled receptor kinase VII | |
| GRK7 |
| Organism | Homo sapiens |
|---|
| GenBank ID | NC_000003 |
|---|---|
| NM_139209 | |
| NP_631948 | |
| NT_005612 | |
| NW_001838884 | |
| NW_921807 | |
| AC_000135 | |
| AC_000046 | |
| AC112504 | |
| CH471052 | |
| EAW78990 | |
| AF282269 | |
| AAL33880 | |
| AF439409 | |
| AAL48216 | |
| Q8WTQ7 | |
| BC148327 | |
| AAI48328 | |
| BC152977 | |
| AAI52978 |
| OMIM ID | 606987 |
|---|
| GO ID | 0005524 |
|---|---|
| 0004703 | |
| 0000166 | |
| 0004871 | |
| 0016740 | |
| 0006468 | |
| 0050896 | |
| 0007601 | |
| 0016020 | |
| 0007165 |
| Swiss-Prot Accession | Q8WTQ7 |
|---|
| Unigene ID | Hs.680654 |
|---|
| KEGG ID | hsa:131890 |
|---|
| EC Number | 2.7.11.16 |
|---|
| Swiss-Prot ID | GRK7_HUMAN |
|---|
| Cell Localization | Membrane |
|---|---|
| Cytoplasm |
| IPI ID | IPI00102804 |
|---|
| RGD ID | 1347561 |
|---|