| URN | urn:agi-llid:2779 |
|---|---|
| Connectivity | 90 |
| Name | Gnat1 |
| Description | guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1 |
| Notes | Transducin is a 3-subunit guanine nucleotide-binding protein (G protein) which stimulates the coupling of rhodopsin and cGMP-phoshodiesterase during visual impulses. The transducin alpha subunits in rods and cones are encoded by separate genes. This gene encodes the alpha subunit in rods. This gene is also expressed in other cells, and has been implicated in bitter taste transduction in rat taste cells. Mutations in this gene result in autosomal dominant congenital stationary night blindness. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq] |
| Pathway | visual phototransduction pathway |
|---|
| GO Molecular Function | signal transducer activity |
|---|---|
| acyl binding | |
| nucleotide binding | |
| G-protein beta-gamma-subunit binding | |
| protein kinase binding | |
| guanyl nucleotide binding | |
| GDP binding | |
| GTP binding | |
| GTPase activity |
| GO Cellular Component | photoreceptor inner segment |
|---|---|
| membrane | |
| photoreceptor outer segment membrane | |
| plasma membrane | |
| neuronal cell body | |
| cytoplasm | |
| membrane fraction | |
| apical plasma membrane | |
| heterotrimeric G-protein complex | |
| photoreceptor outer segment | |
| photoreceptor connecting cilium |
| GO Biological Process | cell proliferation |
|---|---|
| response to stimulus | |
| eye photoreceptor cell development | |
| visual perception | |
| sensory perception of umami taste | |
| phototransduction | |
| signal transduction | |
| phototransduction, visible light | |
| G-protein signaling, coupled to cGMP nucleotide second messenger | |
| rhodopsin mediated phototransduction | |
| GTP catabolic process | |
| detection of chemical stimulus involved in sensory perception of bitter taste | |
| detection of light stimulus involved in visual perception | |
| response to light stimulus | |
| response to light intensity | |
| G-protein coupled receptor protein signaling pathway | |
| positive regulation of cyclic-nucleotide phosphodiesterase activity | |
| negative regulation of cyclic-nucleotide phosphodiesterase activity |
| Ariadne Ontology | Gt |
|---|
| Group | Gt |
|---|---|
| cell proliferation | |
| response to stimulus | |
| eye photoreceptor cell development | |
| visual perception | |
| sensory perception of umami taste | |
| phototransduction | |
| signal transduction | |
| phototransduction, visible light | |
| G-protein signaling, coupled to cGMP nucleotide second messenger | |
| rhodopsin mediated phototransduction | |
| GTP catabolic process | |
| detection of chemical stimulus involved in sensory perception of bitter taste | |
| detection of light stimulus involved in visual perception | |
| response to light stimulus | |
| response to light intensity | |
| G-protein coupled receptor protein signaling pathway | |
| positive regulation of cyclic-nucleotide phosphodiesterase activity | |
| negative regulation of cyclic-nucleotide phosphodiesterase activity | |
| signal transducer activity | |
| acyl binding | |
| nucleotide binding | |
| G-protein beta-gamma-subunit binding | |
| protein kinase binding | |
| guanyl nucleotide binding | |
| GDP binding | |
| GTP binding | |
| GTPase activity | |
| photoreceptor inner segment | |
| membrane | |
| photoreceptor outer segment membrane | |
| plasma membrane | |
| neuronal cell body | |
| cytoplasm | |
| membrane fraction | |
| apical plasma membrane | |
| heterotrimeric G-protein complex | |
| photoreceptor outer segment | |
| photoreceptor connecting cilium |
| MedScan ID | 2779 |
|---|
| Hugo ID | 4393 |
|---|
| Human chromosome position | 3p21 |
|---|
| LocusLink ID | 2779 |
|---|---|
| 14685 | |
| 363143 |
| Alias | GBT1 |
|---|---|
| GNATR | |
| CSNBAD3 | |
| guanine nucleotide-binding protein G(t) subunit alpha-1 | |
| transducin alpha-1 chain | |
| transducin, rod-specific | |
| rod-type transducin alpha subunit | |
| guanine nucleotide-binding protein G(T), alpha-1 subunit | |
| Gnat-1 | |
| Tralpha | |
| transducin | |
| rCG_26094 | |
| (G protein), alpha transducing activity polypeptide 1 | |
| (G protein), alpha transducing activity polypeptide I | |
| G(T), alpha I | |
| G(T), alpha-1 | |
| G(T), alpha-1 subunit | |
| GBT I | |
| Gnat I | |
| Gnat1 | |
| guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1 | |
| guanine nucleotide binding protein, alpha transducing 1 | |
| guanine nucleotide binding protein, alpha transducing activity polypeptide 1 | |
| guanine nucleotide binding protein, alpha transducing I | |
| guanine nucleotide binding, alpha transducing | |
| guanine nucleotide binding, alpha transducing activity polypeptide |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 139330 |
|---|---|
| 610444 |
| Mouse chromosome position | 9 59.0 cM |
|---|
| GO ID | 0031683 |
|---|---|
| 0019003 | |
| 0005525 | |
| 0003924 | |
| 0000035 | |
| 0019001 | |
| 0000166 | |
| 0019901 | |
| 0004871 | |
| 0007186 | |
| 0008283 | |
| 0050908 | |
| 0042462 | |
| 0051344 | |
| 0007603 | |
| 0009416 | |
| 0050896 | |
| 0050917 | |
| 0007165 | |
| 0007601 | |
| 0016020 | |
| 0032391 | |
| 0001917 | |
| 0001750 | |
| 0042622 | |
| 0005886 | |
| 0007199 | |
| 0001580 | |
| 0007602 | |
| 0051343 | |
| 0009642 | |
| 0009586 | |
| 0016324 | |
| 0005737 | |
| 0005834 | |
| 0005624 | |
| 0043025 | |
| 0006184 |
| Rat chromosome position | 8q32 |
|---|
| Swiss-Prot Accession | P11488 |
|---|---|
| P20612 | |
| Q80X34 | |
| Q4VBN2 |
| PIR ID | A33352 |
|---|---|
| S22953 |
| Unigene ID | Hs.517978 |
|---|---|
| Mm.284853 | |
| Rn.8781 |
| KEGG ID | hsa:2779 |
|---|---|
| mmu:14685 | |
| rno:363143 |
| Swiss-Prot ID | GNAT1_MOUSE |
|---|---|
| GNAT1_HUMAN |
| Cell Localization | Cytoplasm |
|---|
| IPI ID | IPI00330646 |
|---|---|
| IPI00218488 | |
| IPI00792370 | |
| IPI00366719 |
| Homologene ID | 20084 |
|---|
| RGD ID | 1304683 |
|---|
| MGI ID | 95778 |
|---|