| URN | urn:agi-llid:2986 |
|---|---|
| Connectivity | 6 |
| Name | Gucy2f |
| Description | guanylate cyclase 2F, retinal |
| Notes | The protein encoded by this gene is a guanylyl cyclase found predominantly in photoreceptors in the retina. The encoded protein is thought to be involved in resynthesis of cGMP after light activation of the visual signal transduction cascade, allowing a return to the dark state. This protein is a single-pass type I membrane protein. Defects in this gene may be a cause of X-linked retinitis pigmentosa. [provided by RefSeq] |
| Pathway | visual phototransduction pathway |
|---|
| GO Molecular Function | nucleotide binding |
|---|---|
| lyase activity | |
| protein homodimerization activity | |
| protein heterodimerization activity | |
| ATP binding | |
| GTP binding | |
| guanylate cyclase activity | |
| phosphorus-oxygen lyase activity | |
| protein kinase activity | |
| receptor activity |
| GO Cellular Component | membrane |
|---|---|
| nuclear outer membrane | |
| membrane fraction | |
| integral to membrane | |
| integral to plasma membrane |
| GO Biological Process | response to stimulus |
|---|---|
| visual perception | |
| cGMP biosynthetic process | |
| cyclic nucleotide biosynthetic process | |
| protein amino acid phosphorylation | |
| intracellular signaling pathway | |
| receptor guanylyl cyclase signaling pathway |
| Ariadne Ontology | GCR |
|---|
| Group | GCR |
|---|---|
| response to stimulus | |
| visual perception | |
| cGMP biosynthetic process | |
| cyclic nucleotide biosynthetic process | |
| protein amino acid phosphorylation | |
| intracellular signaling pathway | |
| receptor guanylyl cyclase signaling pathway | |
| nucleotide binding | |
| lyase activity | |
| protein homodimerization activity | |
| protein heterodimerization activity | |
| ATP binding | |
| GTP binding | |
| guanylate cyclase activity | |
| phosphorus-oxygen lyase activity | |
| protein kinase activity | |
| receptor activity | |
| membrane | |
| nuclear outer membrane | |
| membrane fraction | |
| integral to membrane | |
| integral to plasma membrane |
| MedScan ID | 2986 |
|---|
| Hugo ID | 4691 |
|---|
| Human chromosome position | Xq22 |
|---|
| LocusLink ID | 2986 |
|---|---|
| 245650 | |
| 116556 |
| Alias | CYGF |
|---|---|
| GC-F | |
| GUC2F | |
| GUC2DL | |
| RETGC-2 | |
| ROS-GC2 | |
| retinal guanylyl cyclase 2 | |
| guanylate cyclase F | |
| rod outer segment membrane guanylate cyclase 2 | |
| guanylate cyclase 2D-like, membrane (retina-specific) | |
| GC2 | |
| A930002I06 | |
| RP23-294O1.4 | |
| OTTMUSP00000020265 | |
| guanylate cyclase 2F, retinal | |
| RETGC2 | |
| guanylate cyclase 2F | |
| guanylyl cyclase 2f | |
| GUCY2F | |
| OTTHUMP00000023839 | |
| RetGC II | |
| Rod outer segment membrane guanylate cyclase II |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 300041 |
|---|
| Mouse chromosome position | X 61.0 cM |
|---|
| GO ID | 0005524 |
|---|---|
| 0005525 | |
| 0004383 | |
| 0000166 | |
| 0004672 | |
| 0004872 | |
| 0023034 | |
| 0006468 | |
| 0007168 | |
| 0050896 | |
| 0007601 | |
| 0005887 | |
| 0016020 | |
| 0005640 | |
| 0016829 | |
| 0016849 | |
| 0046982 | |
| 0042803 | |
| 0006182 | |
| 0009190 | |
| 0016021 | |
| 0005624 | |
| 0007242 |
| Rat chromosome position | Xq14 |
|---|
| Swiss-Prot Accession | P51841 |
|---|---|
| Q5SDA5 | |
| P51842 | |
| Q8BLL8 | |
| Q9UJF1 |
| PIR ID | I59385 |
|---|---|
| B55915 |
| Unigene ID | Hs.123074 |
|---|---|
| Mm.208511 | |
| Rn.10061 |
| KEGG ID | hsa:2986 |
|---|---|
| mmu:245650 | |
| rno:116556 |
| EC Number | 4.6.1.2 |
|---|
| Swiss-Prot ID | GUC2F_MOUSE |
|---|---|
| GUC2F_HUMAN | |
| GUC2F_RAT |
| Cell Localization | Membrane |
|---|---|
| Plasma membrane |
| IPI ID | IPI00345822 |
|---|---|
| IPI00020942 | |
| IPI00206274 |
| Homologene ID | 37491 |
|---|
| RGD ID | 620439 |
|---|
| MGI ID | 105119 |
|---|