| URN | urn:agi-llid:6295 |
|---|---|
| Connectivity | 98 |
| Name | Sag |
| Description | S-antigen; retina and pineal gland (arrestin) |
| Notes | Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. S-arrestin, also known as S-antigen, is a major soluble photoreceptor protein that is involved in desensitization of the photoactivated transduction cascade. It is expressed in the retina and the pineal gland and inhibits coupling of rhodopsin to transducin in vitro. Additionally, S-arrestin is highly antigenic, and is capable of inducing experimental autoimmune uveoretinitis. Mutations in this gene have been associated with Oguchi disease, a rare autosomal recessive form of night blindness. [provided by RefSeq] |
| Pathway | visual phototransduction pathway |
|---|
| GO Molecular Function | phosphoprotein binding |
|---|---|
| opsin binding | |
| calcium ion binding | |
| phosphoprotein phosphatase inhibitor activity |
| GO Biological Process | response to stimulus |
|---|---|
| sensory perception | |
| visual perception | |
| signal transduction | |
| rhodopsin mediated phototransduction | |
| cell surface receptor linked signaling pathway | |
| rhodopsin mediated signaling pathway |
| Group | response to stimulus |
|---|---|
| sensory perception | |
| visual perception | |
| signal transduction | |
| rhodopsin mediated phototransduction | |
| cell surface receptor linked signaling pathway | |
| rhodopsin mediated signaling pathway | |
| phosphoprotein binding | |
| opsin binding | |
| calcium ion binding | |
| phosphoprotein phosphatase inhibitor activity |
| MedScan ID | 6295 |
|---|
| Hugo ID | 10521 |
|---|
| Human chromosome position | 2q37.1 |
|---|
| LocusLink ID | 6295 |
|---|---|
| 20215 | |
| 25539 |
| Alias | RP47 |
|---|---|
| S-AG | |
| DKFZp686D1084 | |
| DKFZp686I1383 | |
| S-arrestin | |
| arrestin 1 | |
| 48 kDa protein | |
| OTTHUMP00000203381 | |
| rod photoreceptor arrestin | |
| retinal S-antigen (48 KDa protein) | |
| Arr1 | |
| Irbp | |
| arrestin | |
| A930001K18Rik | |
| rod arrestin | |
| OTTMUSP00000024441 | |
| SAGMR | |
| SANTI | |
| S-antigen | |
| retinal S-antigen | |
| 48 kDa arrestin | |
| A930001K18 | |
| arrestin-S | |
| retina and pineal gland S-antigen | |
| retinal S-antigen (48 KDa) | |
| SAG antigen | |
| SAG gene | |
| SAG protein | |
| S-antigen, retina and pineal gland (arrestin) | |
| S-antigen; retina and pineal gland (arrestin) | |
| synArfGEF | |
| visual arrestin |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 181031 |
|---|---|
| 258100 |
| Mouse chromosome position | 1 53.6 cM |
|---|
| GO ID | 0002046 |
|---|---|
| 0051219 | |
| 0004864 | |
| 0007166 | |
| 0050896 | |
| 0009586 | |
| 0016056 | |
| 0007600 | |
| 0007165 | |
| 0007601 | |
| 0005509 |
| Rat chromosome position | 9q35 |
|---|
| Swiss-Prot Accession | A0FDN6 |
|---|---|
| P10523 | |
| Q6MZK5 | |
| Q7Z3R3 | |
| P20443 | |
| Q3UPX6 | |
| Q3UEW3 | |
| Q8BPV0 | |
| Q8C8Y8 | |
| P15887 | |
| Q53SV3 | |
| Q99858 | |
| Q91W62 |
| PIR ID | S03960 |
|---|---|
| A30357 | |
| JS0066 |
| Unigene ID | Hs.32721 |
|---|---|
| Mm.1276 | |
| Rn.9856 |
| KEGG ID | hsa:6295 |
|---|---|
| mmu:20215 | |
| rno:25539 |
| Swiss-Prot ID | ARRS_RAT |
|---|---|
| ARRS_HUMAN | |
| ARRS_MOUSE | |
| A0FDN6_HUMAN | |
| Q3UPX6_MOUSE |
| IPI ID | IPI00327771 |
|---|---|
| IPI00021353 | |
| IPI00229940 | |
| IPI00917616 | |
| IPI00385695 | |
| IPI00425942 | |
| IPI00385032 |
| Homologene ID | 455 |
|---|
| RGD ID | 3619 |
|---|
| MGI ID | 98227 |
|---|