| URN | urn:agi-llid:3656 |
|---|---|
| Connectivity | 39 |
| Name | Irak2 |
| Description | interleukin-1 receptor-associated kinase 2 |
| Notes | IRAK2 encodes the interleukin-1 receptor-associated kinase 2, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. IRAK2 is reported to participate in the IL1-induced upregulation of NF-kappaB. [provided by RefSeq] |
| Pathway | New Pathway (1) |
|---|---|
| interleukin-1 signaling pathway | |
| Toll-like receptor signaling pathway |
| GO Molecular Function | protein homodimerization activity |
|---|---|
| protein heterodimerization activity | |
| ATP binding | |
| protein kinase activity | |
| NF-kappaB-inducing kinase activity |
| GO Cellular Component | cell surface |
|---|---|
| cytosol |
| GO Biological Process | signal transduction |
|---|---|
| activation of NF-kappaB-inducing kinase activity | |
| regulation of cytokine-mediated signaling pathway | |
| I-kappaB kinase-NF-kappaB cascade | |
| negative regulation of transcription factor activity | |
| positive regulation of NF-kappaB transcription factor activity | |
| negative regulation of NF-kappaB transcription factor activity | |
| regulation of apoptosis | |
| protein amino acid phosphorylation | |
| protein amino acid autophosphorylation | |
| lipopolysaccharide-mediated signaling pathway | |
| apoptosis | |
| MyD88-dependent toll-like receptor signaling pathway | |
| interleukin-1-mediated signaling pathway | |
| response to interleukin-1 | |
| inflammatory response |
| Ariadne Ontology | TIRAP |
|---|
| Group | TIRAP |
|---|---|
| signal transduction | |
| activation of NF-kappaB-inducing kinase activity | |
| regulation of cytokine-mediated signaling pathway | |
| I-kappaB kinase-NF-kappaB cascade | |
| negative regulation of transcription factor activity | |
| positive regulation of NF-kappaB transcription factor activity | |
| negative regulation of NF-kappaB transcription factor activity | |
| regulation of apoptosis | |
| protein amino acid phosphorylation | |
| protein amino acid autophosphorylation | |
| lipopolysaccharide-mediated signaling pathway | |
| apoptosis | |
| MyD88-dependent toll-like receptor signaling pathway | |
| interleukin-1-mediated signaling pathway | |
| response to interleukin-1 | |
| inflammatory response | |
| protein homodimerization activity | |
| protein heterodimerization activity | |
| ATP binding | |
| protein kinase activity | |
| NF-kappaB-inducing kinase activity | |
| cell surface | |
| cytosol |
| MedScan ID | 3656 |
|---|
| Hugo ID | 6113 |
|---|
| Human chromosome position | 3p25.3 |
|---|
| LocusLink ID | 3656 |
|---|---|
| 108960 | |
| 362418 |
| Alias | IRAK-2 |
|---|---|
| MGC150550 | |
| interleukin-1 receptor-associated kinase-like 2 | |
| interleukin-1 receptor associated kinase-2 | |
| AI649099 | |
| MGC102586 | |
| 6330415L08Rik | |
| mu-IRAK-2 | |
| OTTMUSP00000028052 | |
| OTTMUSP00000028055 | |
| interleukin-1 receptor-associated kinase 2c | |
| 6330415L08 | |
| IL1 receptor - ssociated kinase 2 | |
| IL1 receptor - ssociated kinase II | |
| interleukin IL1 receptor - ssociated kinase 2 | |
| interleukin IL1 receptor - ssociated kinase II | |
| interleukin-1 receptor-associated kinase II | |
| IRAK II | |
| IRAK IIs | |
| Irak2 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 603304 |
|---|
| Mouse chromosome position | 6 49.5 cM |
|---|
| GO ID | 0005524 |
|---|---|
| 0004704 | |
| 0046982 | |
| 0042803 | |
| 0004672 | |
| 0007249 | |
| 0002755 | |
| 0006954 | |
| 0070498 | |
| 0031663 | |
| 0032088 | |
| 0051092 | |
| 0006468 | |
| 0001959 | |
| 0070555 | |
| 0007165 | |
| 0009986 | |
| 0007250 | |
| 0006915 | |
| 0043433 | |
| 0046777 | |
| 0042981 | |
| 0005829 |
| Rat chromosome position | 4q42 |
|---|
| Swiss-Prot Accession | O43187 |
|---|---|
| Q8CFA1 | |
| Q4QQS0 | |
| Q3U3K2 | |
| Q3U7F5 | |
| Q3UFX2 | |
| Q5U404 | |
| Q6YBR8 | |
| Q6YBR9 | |
| Q6YBS0 | |
| Q6YBS1 | |
| Q8C5M0 | |
| Q8CC82 | |
| Q8CEA0 | |
| B4DQZ6 | |
| Q08AG6 | |
| Q5K546 |
| Unigene ID | Hs.449207 |
|---|---|
| Mm.152142 | |
| Rn.17123 |
| KEGG ID | hsa:3656 |
|---|---|
| mmu:108960 | |
| rno:362418 |
| Swiss-Prot ID | IRAK2_RAT |
|---|---|
| IRAK2_MOUSE | |
| IRAK2_HUMAN |
| Cell Localization | Cytoplasm |
|---|
| IPI ID | IPI00566810 |
|---|---|
| IPI00420934 | |
| IPI00468594 | |
| IPI00624206 | |
| IPI00828977 | |
| IPI00304986 | |
| IPI00856951 | |
| IPI00781754 | |
| IPI00358412 | |
| IPI00557531 |
| Homologene ID | 1207 |
|---|
| RGD ID | 1309584 |
|---|
| MGI ID | 2429603 |
|---|