| URN | urn:agi-llid:54472 |
|---|---|
| Connectivity | 49 |
| Name | Tollip |
| Description | toll interacting protein |
| Notes | This gene encodes a ubiquitin-binding protein that interacts with several Toll-like receptor (TLR) signaling cascade components. The encoded protein regulates inflammatory signaling and is involved in interleukin-1 receptor trafficking and in the turnover of IL1R-associated kinase. [supplied by RefSeq] |
| Pathway | New Pathway (1) |
|---|---|
| interleukin-1 signaling pathway |
| GO Molecular Function | signal transducer activity |
|---|---|
| kinase binding | |
| Toll binding | |
| Toll-like receptor binding |
| GO Cellular Component | cytoplasm |
|---|---|
| interleukin-1 receptor complex | |
| interleukin-18 receptor complex |
| GO Biological Process | immune response |
|---|---|
| leukocyte activation | |
| cell-cell signaling | |
| signal transduction | |
| phosphorylation | |
| innate immune response | |
| inflammatory response | |
| intracellular signaling pathway |
| Ariadne Ontology | TIRAP |
|---|
| Group | TIRAP |
|---|---|
| immune response | |
| leukocyte activation | |
| cell-cell signaling | |
| signal transduction | |
| phosphorylation | |
| innate immune response | |
| inflammatory response | |
| intracellular signaling pathway | |
| signal transducer activity | |
| kinase binding | |
| Toll binding | |
| Toll-like receptor binding | |
| cytoplasm | |
| interleukin-1 receptor complex | |
| interleukin-18 receptor complex |
| MedScan ID | 54472 |
|---|
| Hugo ID | 16476 |
|---|
| Human chromosome position | 11p15.5 |
|---|
| LocusLink ID | 54472 |
|---|---|
| 54473 | |
| 361677 |
| Alias | FLJ33531 |
|---|---|
| IL-1RAcPIP | |
| toll-interacting protein | |
| adapter protein | |
| 4930403G24Rik | |
| 4931428G15Rik | |
| OTTMUSP00000039113 | |
| 4930403G24 | |
| 4930403G24Rik(2) | |
| 4931428G15 | |
| interleukin IL-1RAcPIP | |
| toll interacting protein | |
| Toll-interactive protein | |
| TOLLIP |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 606277 |
|---|
| Mouse chromosome position | 7 |
|---|
| GO ID | 0035325 |
|---|---|
| 0019900 | |
| 0004871 | |
| 0007267 | |
| 0006954 | |
| 0045087 | |
| 0023034 | |
| 0045321 | |
| 0016310 | |
| 0007165 | |
| 0005737 | |
| 0045323 | |
| 0045092 | |
| 0006955 | |
| 0005121 | |
| 0007242 |
| Rat chromosome position | 1q41 |
|---|
| Swiss-Prot Accession | Q6FIE9 |
|---|---|
| Q9H0E2 | |
| Q59FB9 | |
| Q8N8J5 | |
| A6PWS1 | |
| Q9QZ06 | |
| Q8BQL7 | |
| Q8C5G6 | |
| A2RUW1 | |
| Q543N1 | |
| Q9D5P5 | |
| Q9H9E6 | |
| Q9UJ69 |
| Unigene ID | Hs.368527 |
|---|---|
| Mm.103551 | |
| Rn.137040 |
| KEGG ID | hsa:54472 |
|---|---|
| mmu:54473 | |
| rno:361677 |
| Swiss-Prot ID | TOLIP_MOUSE |
|---|---|
| TOLIP_HUMAN | |
| TOLIP_RAT | |
| Q6FIE9_HUMAN | |
| A6PWS1_MOUSE |
| Cell Localization | Cytoplasm |
|---|
| IPI ID | IPI00136618 |
|---|---|
| IPI00100154 | |
| IPI00366104 | |
| IPI00654582 | |
| IPI00167490 | |
| IPI00856279 | |
| IPI00265864 | |
| IPI00886250 | |
| IPI00557228 |
| Homologene ID | 10375 |
|---|
| RGD ID | 1304676 |
|---|
| MGI ID | 1891808 |
|---|