| URN | urn:agi-llid:3556 |
|---|---|
| Connectivity | 30 |
| Name | Il1rap |
| Description | interleukin 1 receptor accessory protein |
| Notes | Interleukin 1 induces synthesis of acute phase and proinflammatory proteins during infection, tissue damage, or stress, by forming a complex at the cell membrane with an interleukin 1 receptor and an accessory protein. This gene encodes the interleukin 1 receptor accessory protein. The protein is a necessary part of the interleukin 1 receptor complex which initiates signalling events that result in the activation of interleukin 1-responsive genes. Alternative splicing of this gene results in two transcript variants encoding two different isoforms, one membrane-bound and one soluble. The ratio of soluble to membrane-bound forms increases during acute-phase induction or stress. [provided by RefSeq] |
| Pathway | IL1R -> NF-kB signaling |
|---|---|
| IL1R -> STAT3 signaling | |
| New Pathway (1) | |
| interleukin-1 signaling pathway |
| GO Molecular Function | signal transducer activity |
|---|---|
| protein binding, bridging | |
| interleukin-1 binding | |
| interleukin-1 receptor binding | |
| interleukin-1 receptor activity | |
| receptor activity | |
| transmembrane receptor activity |
| GO Cellular Component | extracellular region |
|---|---|
| membrane | |
| plasma membrane | |
| intrinsic to membrane | |
| integral to membrane | |
| integral to plasma membrane |
| GO Biological Process | immune response |
|---|---|
| signal transduction | |
| innate immune response | |
| cytokine-mediated signaling pathway | |
| inflammatory response | |
| protein complex assembly | |
| interleukin-2 biosynthetic process |
| Ariadne Ontology | IL1R |
|---|
| Group | IL1R |
|---|---|
| extracellular region | |
| immune response | |
| signal transduction | |
| innate immune response | |
| cytokine-mediated signaling pathway | |
| inflammatory response | |
| protein complex assembly | |
| interleukin-2 biosynthetic process | |
| signal transducer activity | |
| protein binding, bridging | |
| interleukin-1 binding | |
| interleukin-1 receptor binding | |
| interleukin-1 receptor activity | |
| receptor activity | |
| transmembrane receptor activity | |
| membrane | |
| plasma membrane | |
| intrinsic to membrane | |
| integral to membrane | |
| integral to plasma membrane |
| MedScan ID | 3556 |
|---|
| Hugo ID | 5995 |
|---|
| Human chromosome position | 3q28 |
|---|
| LocusLink ID | 3556 |
|---|---|
| 16180 | |
| 25466 |
| Alias | IL1R3 |
|---|---|
| C3orf13 | |
| FLJ37788 | |
| IL-1RAcP | |
| interleukin-1 receptor accessory protein | |
| IL-1R3 | |
| IL-1R-3 | |
| OTTHUMP00000209486 | |
| OTTHUMP00000209487 | |
| OTTHUMP00000209488 | |
| OTTHUMP00000209489 | |
| OTTHUMP00000209490 | |
| OTTHUMP00000209491 | |
| OTTHUMP00000209492 | |
| interleukin-1 receptor 3 | |
| IL-1 receptor accessory protein | |
| interleukin-1 receptor accessory protein beta | |
| AI255955 | |
| AV239853 | |
| 6430709H04Rik | |
| Il1racpb | |
| MGC114349 | |
| IL1 RAP | |
| IL-1R AcP | |
| interleukin 1 receptor accessory protein | |
| interleukin IL1 RAP | |
| interleukin IL1 receptor accessory protein | |
| interleukin IL1 receptor accessory protein beta | |
| interleukin IL-1R AcP | |
| interleukin IL1R3 | |
| interleukin IL-1RACP |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 602626 |
|---|
| Mouse chromosome position | 16 |
|---|
| GO ID | 0004908 |
|---|---|
| 0004871 | |
| 0004888 | |
| 0006955 | |
| 0006954 | |
| 0045087 | |
| 0006461 | |
| 0005576 | |
| 0005887 | |
| 0005886 | |
| 0004872 | |
| 0019221 | |
| 0042094 | |
| 0007165 | |
| 0016021 | |
| 0031224 | |
| 0016020 | |
| 0019966 | |
| 0005149 | |
| 0030674 |
| Rat chromosome position | 11q22 |
|---|
| Swiss-Prot Accession | Q9NPH3 |
|---|---|
| B1NLD0 | |
| Q8N9C1 | |
| Q3V2X3 | |
| Q3UVZ1 | |
| Q61730 | |
| Q3UEL3 | |
| Q63621 | |
| Q4V8K9 | |
| Q76LI3 | |
| Q8VCB9 | |
| O14915 | |
| Q86WJ7 | |
| A8K6K4 | |
| D3DNW0 | |
| D1M8S3 |
| PIR ID | A57535 |
|---|
| Unigene ID | Hs.478673 |
|---|---|
| Mm.253424 | |
| Rn.10511 |
| KEGG ID | hsa:3556 |
|---|---|
| mmu:16180 | |
| rno:25466 |
| Swiss-Prot ID | IL1AP_RAT |
|---|---|
| IL1AP_MOUSE | |
| IL1AP_HUMAN | |
| A8K6K4_HUMAN | |
| Q3UEL3_MOUSE | |
| Q3V2X3_MOUSE | |
| D3DNW0_HUMAN | |
| D1M8S3_RAT | |
| B1NLD0_HUMAN | |
| Q3UVZ1_MOUSE |
| Cell Localization | Membrane |
|---|---|
| Cell membrane | |
| Secreted | |
| Plasma membrane |
| IPI ID | IPI00211004 |
|---|---|
| IPI00113879 | |
| IPI00124823 | |
| IPI00031789 | |
| IPI00107619 | |
| IPI00337687 | |
| IPI00653610 | |
| IPI00563608 | |
| IPI00925621 | |
| IPI00929886 | |
| IPI00337688 | |
| IPI00167680 |
| Homologene ID | 1643 |
|---|
| RGD ID | 2893 |
|---|
| MGI ID | 104975 |
|---|