| URN | urn:agi-llid:3554 |
|---|---|
| Connectivity | 139 |
| Name | Il1r1 |
| Description | interleukin 1 receptor, type I |
| Notes | The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein is a receptor for interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA). It is an important mediator involved in many cytokine induced immune and inflammatory responses. This gene along with interleukin 1 receptor, type II (IL1R2), interleukin 1 receptor-like 2 (IL1RL2), and interleukin 1 receptor-like 1 (IL1RL1) form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. [provided by RefSeq] |
| Pathway | IL1R -> NF-kB signaling |
|---|---|
| IL1R -> STAT3 signaling | |
| New Pathway (1) | |
| interleukin-1 signaling pathway |
| GO Molecular Function | signal transducer activity |
|---|---|
| platelet-derived growth factor receptor binding | |
| interleukin-1 receptor activity | |
| interleukin-1, Type I, activating receptor activity | |
| receptor activity | |
| transmembrane receptor activity |
| GO Cellular Component | cell surface |
|---|---|
| membrane | |
| intrinsic to membrane | |
| integral to membrane | |
| integral to plasma membrane |
| GO Biological Process | immune response |
|---|---|
| ovulation | |
| signal transduction | |
| innate immune response | |
| cytokine-mediated signaling pathway | |
| interleukin-1-mediated signaling pathway | |
| response to interleukin-1 | |
| cell surface receptor linked signaling pathway |
| Ariadne Ontology | IL1R |
|---|
| Group | IL1R |
|---|---|
| immune response | |
| ovulation | |
| signal transduction | |
| innate immune response | |
| cytokine-mediated signaling pathway | |
| interleukin-1-mediated signaling pathway | |
| response to interleukin-1 | |
| cell surface receptor linked signaling pathway | |
| signal transducer activity | |
| platelet-derived growth factor receptor binding | |
| interleukin-1 receptor activity | |
| interleukin-1, Type I, activating receptor activity | |
| receptor activity | |
| transmembrane receptor activity | |
| cell surface | |
| membrane | |
| intrinsic to membrane | |
| integral to membrane | |
| integral to plasma membrane |
| MedScan ID | 3554 |
|---|
| Hugo ID | 5993 |
|---|
| Human chromosome position | 2q12 |
|---|
| LocusLink ID | 3554 |
|---|---|
| 16177 | |
| 25663 |
| Alias | P80 |
|---|---|
| IL1R | |
| IL1RA | |
| CD121A | |
| D2S1473 | |
| IL-1R-alpha | |
| interleukin-1 receptor type 1 | |
| IL-1R-1 | |
| IL-1RT1 | |
| IL-1RT-1 | |
| antigen CD121a | |
| OTTHUMP00000161344 | |
| OTTHUMP00000203887 | |
| OTTHUMP00000203888 | |
| OTTHUMP00000203889 | |
| OTTHUMP00000203891 | |
| OTTHUMP00000207977 | |
| interleukin receptor 1 | |
| interleukin-1 receptor alpha | |
| interleukin-1 receptor type I | |
| CD121 antigen-like family member A | |
| interleukin 1 receptor alpha, type I | |
| IL-iR | |
| CD121b | |
| Il1r-1 | |
| MGC129154 | |
| IL-1 receptor alpha chain | |
| interleukin 1 beta receptor type 1 soluble form | |
| interleukin 1 bete receptor type 1 long transmembrane form | |
| interleukin 1 beta receptor type 1 short transmembrane form | |
| IL1RT1 | |
| il1r1 | |
| IL1 receptor 1 | |
| IL1 Receptor alpha | |
| IL1 receptor I | |
| IL1R I | |
| IL1R_HUMAN | |
| interleukin 1 beta receptor type 1 long transmembrane form | |
| interleukin 1 receptor 1 | |
| interleukin 1 receptor alpha, type 1 | |
| interleukin 1 receptor, type I | |
| interleukin IL1 receptor 1 | |
| interleukin IL1 receptor alpha | |
| interleukin IL1 receptor alpha, type 1 | |
| interleukin IL1 receptor alpha, type I | |
| interleukin IL1 receptor I | |
| interleukin IL1R I | |
| interleukin IL1R_HUMAN | |
| interleukin IL1R1 | |
| interleukin IL-1R-alpha |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 147810 |
|---|
| Mouse chromosome position | 1 19.5 cM |
|---|
| GO ID | 0004908 |
|---|---|
| 0004909 | |
| 0005161 | |
| 0004871 | |
| 0004888 | |
| 0007166 | |
| 0006955 | |
| 0045087 | |
| 0070498 | |
| 0030728 | |
| 0070555 | |
| 0009986 | |
| 0005887 | |
| 0016020 | |
| 0004872 | |
| 0019221 | |
| 0007165 | |
| 0016021 | |
| 0031224 |
| Rat chromosome position | 9q21 |
|---|
| Swiss-Prot Accession | P14778 |
|---|---|
| Q587I7 | |
| Q6NWP5 | |
| Q6NWP6 | |
| Q8C6P3 | |
| Q8C833 | |
| P13504 | |
| Q32MH0 | |
| Q05KR1 | |
| Q02955 | |
| Q05KR0 | |
| Q05KR2 | |
| Q62692 | |
| Q76LI4 |
| PIR ID | A32604 |
|---|---|
| A36187 |
| Unigene ID | Hs.701982 |
|---|---|
| Mm.896 | |
| Rn.9758 |
| KEGG ID | hsa:3554 |
|---|---|
| mmu:16177 | |
| rno:25663 |
| Swiss-Prot ID | IL1R1_MOUSE |
|---|---|
| IL1R1_HUMAN | |
| Q587I7_HUMAN | |
| Q32MH0_MOUSE | |
| Q8C6P3_MOUSE | |
| Q8C833_MOUSE | |
| Q05KR1_RAT |
| Cell Localization | Membrane |
|---|---|
| Plasma membrane |
| IPI ID | IPI00122581 |
|---|---|
| IPI00027508 | |
| IPI00875537 | |
| IPI00231728 |
| Homologene ID | 677 |
|---|
| RGD ID | 2892 |
|---|
| MGI ID | 96545 |
|---|