| URN | urn:agi-llid:3552 |
|---|---|
| Connectivity | 1060 |
| Name | Il1a |
| Description | interleukin 1, alpha |
| Notes | The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimer's disease. [provided by RefSeq] |
| Pathway | IL1R -> NF-kB signaling |
|---|---|
| IL1R -> STAT3 signaling | |
| New Pathway (1) | |
| interleukin-1 signaling pathway |
| GO Molecular Function | cytokine activity |
|---|---|
| interleukin-1 receptor binding | |
| interleukin-1, Type I receptor binding | |
| copper ion binding |
| GO Cellular Component | extracellular region |
|---|---|
| cell surface | |
| extracellular space | |
| cytosol |
| GO Biological Process | cell proliferation |
|---|---|
| negative regulation of cell proliferation | |
| immune response | |
| positive regulation of angiogenesis | |
| fever | |
| positive regulation vascular endothelial growth factor production | |
| positive regulation of interleukin-6 production | |
| positive regulation of cytokine secretion | |
| positive regulation of interleukin-2 biosynthetic process | |
| regulation of sensory perception of pain | |
| positive regulation of cell division | |
| positive regulation of mitosis | |
| positive regulation of I-kappaB kinase-NF-kappaB cascade | |
| positive regulation of stress-activated MAPK cascade | |
| positive regulation of JNK cascade | |
| positive regulation of ERK1 and ERK2 cascade | |
| anti-apoptosis | |
| cellular response to heat | |
| apoptosis | |
| cytokine-mediated signaling pathway | |
| response to organic substance | |
| response to ozone | |
| response to organic nitrogen | |
| response to organic cyclic substance | |
| response to copper ion | |
| response to lipopolysaccharide | |
| response to L-ascorbic acid | |
| inflammatory response | |
| wound healing | |
| response to gamma radiation | |
| positive regulation of steroid biosynthetic process |
| Ariadne Ontology | IL1 family |
|---|
| Group | IL1 family |
|---|---|
| extracellular region | |
| cell proliferation | |
| negative regulation of cell proliferation | |
| immune response | |
| positive regulation of angiogenesis | |
| fever | |
| positive regulation vascular endothelial growth factor production | |
| positive regulation of interleukin-6 production | |
| positive regulation of cytokine secretion | |
| positive regulation of interleukin-2 biosynthetic process | |
| regulation of sensory perception of pain | |
| positive regulation of cell division | |
| positive regulation of mitosis | |
| positive regulation of I-kappaB kinase-NF-kappaB cascade | |
| positive regulation of stress-activated MAPK cascade | |
| positive regulation of JNK cascade | |
| positive regulation of ERK1 and ERK2 cascade | |
| anti-apoptosis | |
| cellular response to heat | |
| apoptosis | |
| cytokine-mediated signaling pathway | |
| response to organic substance | |
| response to ozone | |
| response to organic nitrogen | |
| response to organic cyclic substance | |
| response to copper ion | |
| response to lipopolysaccharide | |
| response to L-ascorbic acid | |
| inflammatory response | |
| wound healing | |
| response to gamma radiation | |
| positive regulation of steroid biosynthetic process | |
| cytokine activity | |
| interleukin-1 receptor binding | |
| interleukin-1, Type I receptor binding | |
| copper ion binding | |
| cell surface | |
| extracellular space | |
| cytosol |
| MedScan ID | 3552 |
|---|
| Hugo ID | 5991 |
|---|
| Human chromosome position | 2q14 |
|---|
| LocusLink ID | 3552 |
|---|---|
| 16175 | |
| 24493 |
| Alias | IL1 |
|---|---|
| IL-1A | |
| IL1F1 | |
| IL1-ALPHA | |
| interleukin-1 alpha | |
| IL-1 alpha | |
| hematopoietin-1 | |
| OTTHUMP00000203692 | |
| preinterleukin 1 alpha | |
| pro-interleukin-1-alpha | |
| RP23-160G19.8 | |
| OTTMUSP00000016430 | |
| Hematopoietin I | |
| IL1A | |
| IL1alpha | |
| IL1F I | |
| interleukin 1 alpha | |
| interleukin IL1A | |
| interleukin IL1alpha | |
| interleukin IL1F I | |
| interleukin IL1F1 | |
| Interleukin-1 alpha subunit | |
| Interleukin-1 large subunit | |
| preinterleukin 1 | |
| preinterleukin I |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 147760 |
|---|
| Mouse chromosome position | 2 73.0 cM |
|---|
| GO ID | 0005507 |
|---|---|
| 0005125 | |
| 0005149 | |
| 0006916 | |
| 0006915 | |
| 0008283 | |
| 0034605 | |
| 0019221 | |
| 0001660 | |
| 0006955 | |
| 0006954 | |
| 0008285 | |
| 0070374 | |
| 0043123 | |
| 0046330 | |
| 0045766 | |
| 0051781 | |
| 0050715 | |
| 0045086 | |
| 0032755 | |
| 0045840 | |
| 0010893 | |
| 0032874 | |
| 0010575 | |
| 0051930 | |
| 0033591 | |
| 0046688 | |
| 0010332 | |
| 0032496 | |
| 0014070 | |
| 0010243 | |
| 0010193 | |
| 0042060 | |
| 0009986 | |
| 0005829 | |
| 0005576 | |
| 0005615 | |
| 0005150 | |
| 0010033 |
| Rat chromosome position | 3q36 |
|---|
| Swiss-Prot Accession | P01583 |
|---|---|
| Q53QF9 | |
| P01582 | |
| Q3U0Y6 | |
| Q62161 | |
| P16598 | |
| Q71VD0 | |
| Q9ESW2 | |
| Q7RU02 | |
| Q546R9 |
| PIR ID | A01846 |
|---|---|
| A23385 | |
| JX0064 |
| Unigene ID | Hs.1722 |
|---|---|
| Mm.15534 | |
| Rn.12300 |
| KEGG ID | hsa:3552 |
|---|---|
| mmu:16175 | |
| rno:24493 |
| Swiss-Prot ID | IL1A_MOUSE |
|---|---|
| IL1A_HUMAN | |
| IL1A_RAT | |
| Q53QF9_HUMAN | |
| Q3U0Y6_MOUSE |
| Cell Localization | Secreted |
|---|---|
| Extracellular |
| IPI ID | IPI00136895 |
|---|---|
| IPI00003096 | |
| IPI00213945 | |
| IPI00192438 | |
| IPI00781873 |
| Homologene ID | 480 |
|---|
| RGD ID | 2890 |
|---|
| MGI ID | 96542 |
|---|