Ariadne Genomics Inc. NLRP1 inflammasome Myd88 Tollip AIM2 inflammasome NLRP3 inflammasome Map3k7-Tab(s) complex Pellino members Ube2n Il1rap Il1r1 Il-1beta processing cytTraf6 --+> cytMap3k7 cytTraf6 ---- Ube2v1 cytTraf6 ---- Ube2n Pellino members ---> diss-Irak1 diss-Irak1 ---> Pellino members diss-Traf6 ---- Map3k7-Tab(s) complex diss-Irak1 ---- diss-Traf6 diss-Irak1 ---- Map3k7-Tab(s) complex Il1r1 ---- negative regulators Il1rap ---- negative regulators Il1a ---- Il1r1 cytMap3k7 --+> c-Jun N-terminal kinases MAPK signaling pathway cytMap3k7 --+> p38 MAPK signaling pathway cytMap3k7 --+> nuclear factor kappa B signaling pathway Irak1 ---- Myd88 Irak4 ---- Myd88 Irak1 ---- Traf6 Il1r1 ---- Il1rap Il1rap ---- Myd88 Il1r1 ---- Myd88 Il1rap ---- Tollip Il1r1 ---- Tollip Irak4 ---> Irak1 K63-polyubiquitination Irak4 ---> Irak2 Irak4 Traf6 Irak2 Irak1 Ube2v1 Il1a Il1b Il1b ---- Il1r1 diss-Irak1 diss-Traf6 NLRP3 inflammasome ---> Il-1beta processing NLRP1 inflammasome ---> Il-1beta processing AIM2 inflammasome ---> Il-1beta processing p38 MAPK signaling pathway c-Jun N-terminal kinases MAPK signaling pathway nuclear factor kappa B signaling pathway Il-1beta secretion Il-1beta processing ---> Il-1beta secretion cytTraf6 negative regulators ---| Il1rap negative regulators ---| Il1r1 negative regulators cytTab(s) cytMap3k7