Ariadne Genomics Inc. gefitinib other gefitinib metabolites O-desmethyl-gefitinib Egfr ---> gefitinib resistance gefitinib resistance Egfr ---- O-desmethyl-gefitinib ATP ---| Egfr ATP gefitinib pharmacokinetics pathway Egfr ---- gefitinib Egfr ---- other gefitinib metabolites epidermal growth factor/neuregulin signaling pathway ---| non-small cell lung cancer pathway epidermal growth factor/neuregulin signaling pathway ---| Carcinoma, Non-Small-Cell Lung Carcinoma, Non-Small-Cell Lung non-small cell lung cancer pathway Egfr epidermal growth factor/neuregulin signaling pathway Egfr ---| epidermal growth factor/neuregulin signaling pathway