Protein ABCG2

URN	urn:agi-llid:9429
Connectivity	205
Name	ABCG2
Description	ATP-binding cassette, sub-family G (WHITE), member 2
Notes	The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue.

Pathway	statin pharmacokinetics pathway
	gefitinib pharmacokinetics pathway

GO Molecular Function	transporter activity
	nucleotide binding
	protein homodimerization activity
	ATP binding
	ATPase activity, coupled to transmembrane movement of substances
	nucleoside-triphosphatase activity
	ATPase activity
	xenobiotic-transporting ATPase activity
	drug transmembrane transporter activity

GO Biological Process	transport
	embryonic process involved in female pregnancy
	response to drug
	response to folic acid
	response to iron ion
	response to glucocorticoid stimulus
	drug transport
	drug export

Ariadne Ontology	Xenobiotic clearance

Group	Xenobiotic clearance
	transporter activity
	transport
	embryonic process involved in female pregnancy
	response to drug
	response to folic acid
	response to iron ion
	response to glucocorticoid stimulus
	drug transport
	drug export
	nucleotide binding
	protein homodimerization activity
	ATP binding
	ATPase activity, coupled to transmembrane movement of substances
	nucleoside-triphosphatase activity
	ATPase activity
	xenobiotic-transporting ATPase activity
	drug transmembrane transporter activity
	membrane
	plasma membrane
	apical plasma membrane
	integral to membrane

MedScan ID	9429

Hugo ID	74

Human chromosome position	4q22

Alias	MRX
	MXR
	ABCP
	BCRP
	BMDP
	MXR1
	ABC15
	BCRP1
	CD338
	CDw338
	EST157481
	MGC102821
	ATP-binding cassette sub-family G member 2
	ABC transporter
	placenta specific MDR protein
	mitoxantrone resistance protein
	breast cancer resistance protein
	ATP-binding cassette transporter G2
	mitoxantrone resistance-associated protein
	placenta-specific ATP-binding cassette transporter
	AI428558
	OTTMUSP00000025071
	OTTMUSP00000025391
	mitoxantrone resistance protein 1
	breast cancer resistance protein 1 homolog
	ATP-binding cassette protein G2
	ABC transporter ABCG2
	Abcg2
	ATP-binding cassette transporter G (WHITE) 2
	ATP-binding cassette transporter G (WHITE) II
	ATP-binding cassette transporter G 2
	ATP-binding cassette transporter G II
	ATP-binding cassette, sub-family G (WHITE), member 2
	ATP-binding cassette, sub-family G (WHITE), member II
	ATP-binding cassette, sub-family G, member 2
	ATP-binding cassette, sub-family G, member II
	mitoxantrone resistance protein I
	MXR I
	Placenta-specific ATP- binding cassette transporter
	ATP-binding cassette sub-family G (WHITE) member 2
	expressed sequence AI428558

OMIM ID	603756

Mouse chromosome position	6 28.5 cM

Rat chromosome position	4q24

Cell Localization	Cell membrane
	Plasma membrane

Homologene ID	55852

RGD ID	1352615

MGI ID	1347061