| URN | urn:agi-llid:1543 |
|---|---|
| Connectivity | 348 |
| Name | CYP1A1 |
| Description | cytochrome P450, family 1, subfamily A, polypeptide 1 |
| Notes | This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15. [provided by RefSeq] |
| Pathway | gefitinib pharmacokinetics pathway |
|---|
| GO Molecular Function | electron carrier activity |
|---|---|
| catalytic activity | |
| oxygen binding | |
| oxidoreductase activity | |
| demethylase activity | |
| enzyme binding | |
| heme binding | |
| metal ion binding | |
| iron ion binding | |
| monooxygenase activity | |
| vitamin D 24-hydroxylase activity | |
| oxidoreductase activity, acting on diphenols and related substances as donors | |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | |
| steroid hydroxylase activity | |
| aromatase activity | |
| flavonoid 3'-monooxygenase activity |
| GO Cellular Component | membrane |
|---|---|
| cytoplasm | |
| endoplasmic reticulum membrane | |
| endoplasmic reticulum | |
| mitochondrion | |
| mitochondrial membrane | |
| microsome |
| GO Biological Process | cell proliferation |
|---|---|
| developmental process | |
| oxidation reduction | |
| response to stress | |
| response to virus | |
| response to nematode | |
| embryonic development ending in birth or egg hatching | |
| digestive tract development | |
| liver development | |
| camera-type eye development | |
| hepatocyte differentiation | |
| maternal process involved in parturition | |
| drug metabolic process | |
| toxin metabolic process | |
| heterocycle metabolic process | |
| positive regulation of S phase of mitotic cell cycle | |
| insecticide metabolic process | |
| dibenzo-p-dioxin metabolic process | |
| coumarin metabolic process | |
| porphyrin metabolic process | |
| hydrogen peroxide biosynthetic process | |
| dibenzo-p-dioxin catabolic process | |
| 9-cis-retinoic acid biosynthetic process | |
| flavonoid metabolic process | |
| response to organic substance | |
| response to drug | |
| response to antibiotic | |
| response to food | |
| response to hyperoxia | |
| response to hypoxia | |
| response to wounding | |
| response to herbicide | |
| response to arsenic | |
| response to organic cyclic substance | |
| response to iron(III) ion | |
| response to lipopolysaccharide | |
| response to vitamin A | |
| amine metabolic process | |
| vitamin D metabolic process |
| Ariadne Ontology | Aromatic amino acid metabolism |
|---|
| Group | Aromatic amino acid metabolism |
|---|---|
| electron carrier activity | |
| catalytic activity | |
| cell proliferation | |
| developmental process | |
| oxidation reduction | |
| response to stress | |
| response to virus | |
| response to nematode | |
| embryonic development ending in birth or egg hatching | |
| digestive tract development | |
| liver development | |
| camera-type eye development | |
| hepatocyte differentiation | |
| maternal process involved in parturition | |
| drug metabolic process | |
| toxin metabolic process | |
| heterocycle metabolic process | |
| positive regulation of S phase of mitotic cell cycle | |
| insecticide metabolic process | |
| dibenzo-p-dioxin metabolic process | |
| coumarin metabolic process | |
| porphyrin metabolic process | |
| hydrogen peroxide biosynthetic process | |
| dibenzo-p-dioxin catabolic process | |
| 9-cis-retinoic acid biosynthetic process | |
| flavonoid metabolic process | |
| response to organic substance | |
| response to drug | |
| response to antibiotic | |
| response to food | |
| response to hyperoxia | |
| response to hypoxia | |
| response to wounding | |
| response to herbicide | |
| response to arsenic | |
| response to organic cyclic substance | |
| response to iron(III) ion | |
| response to lipopolysaccharide | |
| response to vitamin A | |
| amine metabolic process | |
| vitamin D metabolic process | |
| oxygen binding | |
| oxidoreductase activity | |
| demethylase activity | |
| enzyme binding | |
| heme binding | |
| metal ion binding | |
| iron ion binding | |
| monooxygenase activity | |
| vitamin D 24-hydroxylase activity | |
| oxidoreductase activity, acting on diphenols and related substances as donors | |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | |
| steroid hydroxylase activity | |
| aromatase activity | |
| flavonoid 3'-monooxygenase activity | |
| membrane | |
| cytoplasm | |
| endoplasmic reticulum membrane | |
| endoplasmic reticulum | |
| mitochondrion | |
| mitochondrial membrane | |
| microsome |
| MedScan ID | 1543 |
|---|
| Hugo ID | 2595 |
|---|
| Human chromosome position | 15q24.1 |
|---|
| LocusLink ID | 1543 |
|---|---|
| 13076 | |
| 24296 |
| Alias | AHH |
|---|---|
| AHRR | |
| CP11 | |
| CYP1 | |
| P1-450 | |
| P450-C | |
| P450DX | |
| cytochrome P450 1A1 | |
| CYPIA1 | |
| cytochrome P450-C | |
| OTTHUMP00000183469 | |
| cytochrome P450-P1 | |
| cytochrome P450 form 6 | |
| xenobiotic monooxygenase | |
| aryl hydrocarbon hydroxylase | |
| flavoprotein-linked monooxygenase | |
| cytochrome P1-450, dioxin-inducible | |
| cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 1 | |
| Cyp1a2 | |
| P450-1 | |
| aromatic compound inducible | |
| cytochrome P450 subfamily I, polypeptide 1 | |
| cytochrome P450, 1a1, aromatic compound inducible | |
| cytochrome P450 family 1 subfamily a polypeptide 2 | |
| Cyp45c | |
| Cypc45c | |
| P-450MC | |
| P450MT2 | |
| P450form6 | |
| dioxin-inducible | |
| cytochrome P1-450 | |
| cytochrome P450MT2 | |
| cytochrome P450, 1a1 | |
| microsomal monooxygenase | |
| cytochrome P450 subfamily I (aromatic compound-inducible) member A1 (C6 form c) (C6 form c) | |
| cytochrome P450, subfamily I (aromatic compound-inducible), member A1 (C6, form c) (C6, form c) | |
| Cyp1a-1 | |
| CYP I | |
| Cyp1a I | |
| CYP1A1 | |
| CYPIA I | |
| cytochrome P450 1A I | |
| cytochrome P450 1a1 aromatic compound inducible | |
| cytochrome P450 45c | |
| cytochrome P450 I (aromatic compound-inducible) 1 | |
| cytochrome P450 I (aromatic compound-inducible) A1 | |
| cytochrome P450 I (aromatic compound-inducible) I | |
| cytochrome P450 I 1 | |
| cytochrome P450 I I | |
| cytochrome P45045c | |
| P450 (CYP) 1A1 | |
| P450 (CYP) 45c | |
| P450 (CYP) 6 | |
| P450 (CYP) VI | |
| P450 1A1 | |
| P450 45c | |
| P450 6 | |
| P450 VI | |
| P4501A1 | |
| P45045c | |
| P450-Cs | |
| P450-P I | |
| P450-P1 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 108330 |
|---|
| Mouse chromosome position | 9 31.0 cM |
|---|
| GO ID | 0070330 |
|---|---|
| 0032451 | |
| 0009055 | |
| 0019899 | |
| 0016711 | |
| 0020037 | |
| 0046872 | |
| 0016491 | |
| 0016679 | |
| 0019825 | |
| 0008395 | |
| 0070576 | |
| 0042904 | |
| 0009308 | |
| 0043010 | |
| 0008283 | |
| 0009804 | |
| 0032502 | |
| 0019341 | |
| 0048565 | |
| 0017144 | |
| 0009792 | |
| 0009812 | |
| 0070365 | |
| 0050665 | |
| 0017143 | |
| 0060137 | |
| 0055114 | |
| 0006778 | |
| 0045750 | |
| 0046677 | |
| 0046685 | |
| 0042493 | |
| 0032094 | |
| 0009635 | |
| 0055093 | |
| 0001666 | |
| 0010041 | |
| 0032496 | |
| 0009624 | |
| 0014070 | |
| 0009615 | |
| 0033189 | |
| 0009611 | |
| 0042359 | |
| 0005737 | |
| 0005783 | |
| 0005789 | |
| 0016020 | |
| 0005792 | |
| 0005739 | |
| 0003824 | |
| 0005506 | |
| 0004497 | |
| 0016712 | |
| 0018894 | |
| 0046483 | |
| 0009404 | |
| 0001889 | |
| 0010033 | |
| 0006950 | |
| 0031966 |
| Rat chromosome position | 8q24 |
|---|
| Swiss-Prot Accession | A0N0X8 |
|---|---|
| P04798 | |
| Q0VHD5 | |
| Q53G23 | |
| Q5J9B1 | |
| P00184 | |
| Q05A20 | |
| P00185 | |
| Q80UE2 | |
| Q61455 | |
| Q53G18 |
| PIR ID | A23923 |
|---|---|
| A00185 | |
| A24797 |
| Unigene ID | Hs.72912 |
|---|---|
| Mm.14089 | |
| Rn.10352 |
| KEGG ID | hsa:1543 |
|---|---|
| mmu:13076 | |
| rno:24296 |
| EC Number | 1.14.14.1 |
|---|
| Swiss-Prot ID | CP1A1_MOUSE |
|---|---|
| CP1A1_RAT | |
| CP1A1_HUMAN | |
| A0N0X8_HUMAN | |
| Q05A20_MOUSE |
| Cell Localization | Endoplasmic reticulum membrane |
|---|---|
| Microsome membrane | |
| Cytoplasm | |
| Mitochondrion membrane | |
| Endoplasmic reticulum | |
| Mitochondrion |
| IPI ID | IPI00128286 |
|---|---|
| IPI00206995 | |
| IPI00218839 | |
| IPI00871435 | |
| IPI00552572 |
| Homologene ID | 68062 |
|---|
| RGD ID | 730870 |
|---|
| MGI ID | 88588 |
|---|