| URN | urn:agi-llid:1189 |
|---|---|
| Connectivity | 749 |
| Name | ABCB1 |
| Description | ATP-binding cassette, sub-family B (MDR/TAP), member 1 |
| Notes | The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. |
| Pathway | statin pharmacokinetics pathway |
|---|---|
| tamoxifen pharmacokinetics pathway | |
| gefitinib pharmacokinetics pathway |
| GO Molecular Function | transporter activity |
|---|---|
| nucleotide binding | |
| hydrolase activity | |
| ATP binding | |
| ATPase activity, coupled to transmembrane movement of substances | |
| ATPase activity | |
| ATPase activity, coupled | |
| xenobiotic-transporting ATPase activity |
| GO Cellular Component | cell surface |
|---|---|
| membrane | |
| nucleus | |
| membrane fraction | |
| integral to membrane | |
| intercellular canaliculus | |
| focal adhesion |
| GO Biological Process | transmembrane transport |
|---|---|
| transport | |
| lactation | |
| drug transmembrane transport | |
| response to drug | |
| response to organic cyclic substance | |
| response to cadmium ion | |
| response to vitamin D | |
| drug transport |
| Ariadne Ontology | Xenobiotic clearance |
|---|
| Group | Xenobiotic clearance |
|---|---|
| transporter activity | |
| transmembrane transport | |
| transport | |
| lactation | |
| drug transmembrane transport | |
| response to drug | |
| response to organic cyclic substance | |
| response to cadmium ion | |
| response to vitamin D | |
| drug transport | |
| nucleotide binding | |
| hydrolase activity | |
| ATP binding | |
| ATPase activity, coupled to transmembrane movement of substances | |
| ATPase activity | |
| ATPase activity, coupled | |
| xenobiotic-transporting ATPase activity | |
| cell surface | |
| membrane | |
| nucleus | |
| membrane fraction | |
| integral to membrane | |
| intercellular canaliculus | |
| focal adhesion |
| MedScan ID | 1189 |
|---|
| Hugo ID | 40 |
|---|
| Human chromosome position | 7q21.12 |
|---|---|
| 7q21.1 |
| LocusLink ID | 1189 |
|---|---|
| 5243 | |
| 18671 | |
| 170913 |
| Alias | CLCS |
|---|---|
| MDR1 | |
| P-GP | |
| PGY1 | |
| ABC20 | |
| CD243 | |
| GP170 | |
| MGC163296 | |
| multidrug resistance protein 1 | |
| P-glycoprotein 1 | |
| colchicin sensitivity | |
| doxorubicin resistance | |
| ATP-binding cassette sub-family B member 1 | |
| ATP-binding cassette, subfamily B, member 1 | |
| Pgp | |
| Mdr3 | |
| Pgy3 | |
| Abcb4 | |
| Evi32 | |
| Mdr1a | |
| Pgy-3 | |
| mdr-3 | |
| multidrug resistance protein 3 | |
| P glycoprotein 3 | |
| P-glycoprotein 3 | |
| multi-drug resistance 3 | |
| multiple drug resistant 1a | |
| ecotropic viral integration site 32 | |
| ATP-binding cassette sub-family B member 1A | |
| ATP-binding cassette, subfamily B, member 1A | |
| ATP-binding cassette, sub-family B (MDR/TAP), member 4 | |
| Abcb1 | |
| ATP-binding cassette, sub-family B (MDR/TAP), member 1A | |
| ATP-binding cassette, sub-family B (MDR/TAP), member 1 | |
| Abcb I | |
| Abcb1a | |
| Abcb1b | |
| ATP-binding cassette sub-family B member I | |
| ATP-binding cassette transporter B (MDR/TAP) 1 | |
| ATP-binding cassette transporter B (MDR/TAP) 1A | |
| ATP-binding cassette transporter B (MDR/TAP) 1B | |
| ATP-binding cassette transporter B (MDR/TAP) I | |
| ATP-binding cassette, sub-family B (MDR/TAP), member 1B | |
| ATP-binding cassette, sub-family B (MDR/TAP), member I | |
| colchicin sensitivity gene | |
| colchicin sensitivity protein | |
| doxorubicin resistance gene | |
| doxorubicin resistance protein | |
| ecotropic viral integrating site 32 | |
| LOC360377 | |
| LOC497782 | |
| MDR I | |
| MDR-1 P-glycoprotein | |
| Mdr1b | |
| multidrug resistance 1 | |
| multidrug resistance protein 1a | |
| Multidrug resistance protein I | |
| P glycoprotein 1/multiple drug resistance 1 | |
| P-glycoprotein | |
| P-glycoprotein 1A | |
| P-glycoprotein I | |
| P-glycoprotein/multidrug resistance 1 | |
| P-glycoprotein/multidrug resistance I | |
| PGP/MDR1 | |
| PGY I | |
| P-MDR I | |
| P-MDR1 | |
| P-MDR1s | |
| P glycoprotein 1 | |
| multi-drug resistance III | |
| P-MDR Is |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 171050 |
|---|---|
| 612244 |
| Mouse chromosome position | 5 1.0 cM |
|---|
| GO ID | 0005524 |
|---|---|
| 0016887 | |
| 0042626 | |
| 0016787 | |
| 0000166 | |
| 0005215 | |
| 0008559 | |
| 0042493 | |
| 0055085 | |
| 0006810 | |
| 0009986 | |
| 0016021 | |
| 0016020 | |
| 0005624 | |
| 0042623 | |
| 0006855 | |
| 0015893 | |
| 0046581 | |
| 0007595 | |
| 0046686 | |
| 0014070 | |
| 0033280 | |
| 0005925 | |
| 0005634 | |
| 0005515 | |
| 0017111 | |
| 0003674 | |
| 0005575 |
| Rat chromosome position | 4q12 |
|---|
| Swiss-Prot Accession | A4D1D2 |
|---|---|
| P08183 | |
| O60213 | |
| Q59GY9 | |
| Q6TBL4 | |
| P21447 | |
| Q9CVG4 | |
| Q3UMH0 | |
| Q9QX25 | |
| Q9JK64 | |
| Q6PSM0 | |
| Q924L6 | |
| A8K294 | |
| Q12755 | |
| Q14812 | |
| Q5I1Y5 |
| PIR ID | A34914 |
|---|---|
| A34175 | |
| A34786 |
| Unigene ID | Hs.489033 |
|---|---|
| Mm.207354 | |
| Rn.154810 |
| KEGG ID | hsa:5243 |
|---|---|
| mmu:18671 | |
| rno:170913 |
| EC Number | 3.6.3.44 |
|---|
| Swiss-Prot ID | MDR1_HUMAN |
|---|---|
| MDR3_MOUSE | |
| Q9CVG4_MOUSE | |
| A4D1D2_HUMAN | |
| Q9JK64_RAT | |
| Q5I1Y5_MOUSE |
| Cell Localization | Membrane |
|---|---|
| Cell membrane | |
| Plasma membrane |
| IPI ID | IPI00027481 |
|---|---|
| IPI00311780 | |
| IPI00470287 | |
| IPI00792032 | |
| IPI00553834 | |
| IPI00780231 |
| Homologene ID | 55496 |
|---|
| RGD ID | 730823 |
|---|
| MGI ID | 97570 |
|---|