Ariadne Genomics Inc. CYP3A4 CYP3A5 ABCG2 ABCB1 CYP2D6 CYP1A1 gefitinib ---> other gefitinib metabolites gefitinib ---> O-desmethyl-gefitinib gefitinib and metabolites elimination O-desmethyl-gefitinib ---> gefitinib and metabolites elimination other gefitinib metabolites ---> gefitinib and metabolites elimination gefitinib other gefitinib metabolites O-desmethyl-gefitinib