| URN | urn:agi-llid:5634 |
|---|---|
| Connectivity | 1 |
| Name | Prps2 |
| Description | phosphoribosyl pyrophosphate synthetase 2 |
| Notes | This gene encodes a phosphoribosyl pyrophosphate synthetase that plays a central role in the synthesis of purines and pyrimidines. The encoded protein catalyzes the synthesis of 5-phosphoribosyl 1-pyrophosphate from ATP and D-ribose 5-phosphate. Alternate splicing results in multiple transcript variants. [provided by RefSeq] |
| Pathway | de novo purine biosynthetic pathway |
|---|---|
| 'Copy of 'de novo purine biosynthetic pathway' | |
| de novo purine biosynthetic pathwaylatest | |
| Copy of 'de novo purine biosynthetic pathwaylatest' | |
| Copy of 'de novo purine biosynthetic pathwaylatest' | |
| de novo purine biosynthetic pathway |
| GO Molecular Function | nucleotide binding |
|---|---|
| transferase activity | |
| sugar binding | |
| protein homodimerization activity | |
| AMP binding | |
| ADP binding | |
| ATP binding | |
| GDP binding | |
| metal ion binding | |
| magnesium ion binding | |
| kinase activity | |
| ribose phosphate diphosphokinase activity |
| GO Cellular Component | protein complex |
|---|---|
| soluble fraction |
| GO Biological Process | organ regeneration |
|---|---|
| cellular biosynthetic process | |
| nucleobase, nucleoside, nucleotide and nucleic acid metabolic process | |
| ribose phosphate metabolic process | |
| AMP biosynthetic process | |
| nucleotide biosynthetic process | |
| ribonucleoside monophosphate biosynthetic process | |
| nucleoside metabolic process |
| Ariadne Ontology | Pentose-phosphate shunt |
|---|---|
| Purine metabolism |
| Group | Pentose-phosphate shunt |
|---|---|
| Purine metabolism | |
| organ regeneration | |
| cellular biosynthetic process | |
| nucleobase, nucleoside, nucleotide and nucleic acid metabolic process | |
| ribose phosphate metabolic process | |
| AMP biosynthetic process | |
| nucleotide biosynthetic process | |
| ribonucleoside monophosphate biosynthetic process | |
| nucleoside metabolic process | |
| nucleotide binding | |
| transferase activity | |
| sugar binding | |
| protein homodimerization activity | |
| AMP binding | |
| ADP binding | |
| ATP binding | |
| GDP binding | |
| metal ion binding | |
| magnesium ion binding | |
| kinase activity | |
| ribose phosphate diphosphokinase activity | |
| protein complex | |
| soluble fraction |
| MedScan ID | 5634 |
|---|
| Hugo ID | 9465 |
|---|
| Human chromosome position | Xp22.3-p22.2 |
|---|
| LocusLink ID | 5634 |
|---|---|
| 110639 | |
| 24689 |
| Alias | PRSII |
|---|---|
| ribose-phosphate pyrophosphokinase 2 | |
| PRS-II | |
| PPRibP synthetase | |
| OTTHUMP00000214965 | |
| ribose-phosphate diphosphokinase 2 | |
| phosphoribosyl pyrophosphate synthase II | |
| Prps-2 | |
| AA589463 | |
| AI464149 | |
| MGC28388 | |
| 2610101M19Rik | |
| RP23-139P21.4 | |
| OTTMUSP00000021121 | |
| phosphoribosyl pyrophosphate synthetase II | |
| Phophoribosylpyrophosphate synthetase, subunit II | |
| 2610101M19 | |
| OTTHUMP00000022921 | |
| Phophoribosylpyrophosphate synthase, subunit II | |
| phosphoribosyl pyrophosphate synthase 2 | |
| phosphoribosyl pyrophosphate synthetase 2 | |
| phosphoribosylpyrophosphate synthase 2 | |
| phosphoribosylpyrophosphate synthetase 2 | |
| PPRibP 2 | |
| PPRibP II | |
| PPRibP synthase | |
| PRPS2 | |
| PRS II | |
| Ribose-phosphate pyrophosphokinase II |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 311860 |
|---|
| Mouse chromosome position | X 72.0 cM |
|---|
| GO ID | 0005524 |
|---|---|
| 0016301 | |
| 0000287 | |
| 0000166 | |
| 0042803 | |
| 0004749 | |
| 0016740 | |
| 0044249 | |
| 0006139 | |
| 0009116 | |
| 0009165 | |
| 0009156 | |
| 0043531 | |
| 0016208 | |
| 0019003 | |
| 0046872 | |
| 0005529 | |
| 0006167 | |
| 0019693 | |
| 0043234 | |
| 0005625 | |
| 0031100 |
| Rat chromosome position | Xq21 |
|---|
| Swiss-Prot Accession | P11908 |
|---|---|
| A2AHI4 | |
| Q9CS42 | |
| P09330 | |
| Q0VDH9 | |
| Q0VDI0 | |
| Q15245 | |
| Q2TAK7 | |
| Q9CZA9 | |
| Q63462 |
| PIR ID | S02778 |
|---|---|
| B29463 |
| Unigene ID | Hs.654581 |
|---|---|
| Mm.272955 | |
| Rn.11320 |
| KEGG ID | hsa:5634 |
|---|---|
| mmu:110639 | |
| rno:24689 |
| EC Number | 2.7.6.1 |
|---|
| Swiss-Prot ID | PRPS2_HUMAN |
|---|---|
| PRPS2_MOUSE | |
| PRPS2_RAT | |
| A2AHI4_MOUSE |
| Cell Localization | Cytoplasm |
|---|
| IPI ID | IPI00219617 |
|---|---|
| IPI00718888 | |
| IPI00411102 | |
| IPI00288140 | |
| IPI00642461 |
| Homologene ID | 56138 |
|---|
| RGD ID | 3415 |
|---|
| MGI ID | 97776 |
|---|